ARGININE UPTAKE AND ARGINASE ACTIVITY IN EHRLICH ASCITES CARCINOMA CELLS

1959 ◽  
Vol 37 (1) ◽  
pp. 589-598 ◽  
Author(s):  
R. M. Johnstone
Keyword(s):  
Amino Acids ◽  
Tumor Cells ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Arginase Activity ◽  
Anaerobic Glycolysis ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Arginine Uptake ◽  
Ehrlich Ascites

Anaerobic glycolysis in Ehrlich ascites tumor cells exposed to amino acids leads to an increased uptake of a number of the amino acids to levels comparable with those obtained under aerobic conditions. The arginine uptake in the cell is not increased by glucose. Anaerobically the arginase activity is inhibited when glucose is present. The inhibition appears to be the result of an increased retention in the cell of the ornithine produced by arginase activity.

ARGININE UPTAKE AND ARGINASE ACTIVITY IN EHRLICH ASCITES CARCINOMA CELLS

1959 ◽  
Vol 37 (4) ◽  
pp. 589-598 ◽  
Author(s):  
R. M. Johnstone
Keyword(s):  
Amino Acids ◽  
Tumor Cells ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Arginase Activity ◽  
Anaerobic Glycolysis ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Arginine Uptake ◽  
Ehrlich Ascites

Anaerobic glycolysis in Ehrlich ascites tumor cells exposed to amino acids leads to an increased uptake of a number of the amino acids to levels comparable with those obtained under aerobic conditions. The arginine uptake in the cell is not increased by glucose. Anaerobically the arginase activity is inhibited when glucose is present. The inhibition appears to be the result of an increased retention in the cell of the ornithine produced by arginase activity.

Effect of Garlic, Chinese Medicinal Drugs and Amino Acids on Growth of Erlich Ascites Tumor Cells in Mice

1983 ◽  
Vol 11 (01n04) ◽  
pp. 69-73 ◽  
Author(s):  
Y.M. Choy ◽  
T.T. Kwok ◽  
K.P. Fung ◽  
C.Y. Lee
Keyword(s):  
Amino Acids ◽  
Tumor Cells ◽  
Peritoneal Cavity ◽  
Growth And Development ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Tumor Bearing ◽  
Ehrlich Ascites ◽  
Medicinal Drugs ◽  
Growth Of Tumor

A number of food materials or drugs have been screened for the effect on the growth and development of transplantable Ehrlich ascites tumor cells. Growth of tumor-bearing mice was significantly inhibited by feeding garlic as well as some amino acids. These materials significantly reduced the total number of free tumor cells growing in the peritoneal cavity of mice and prolonged significantly the length of time for 50% death of tumor-bearing mice.

THE SYNTHESIS OF EXTRACELLULAR RIBONUCLEOSIDES BY ASCITES TUMOR CELLS IN VITRO

1965 ◽  
Vol 43 (2) ◽  
pp. 257-269 ◽  
Author(s):  
A. R. P. Paterson
Keyword(s):  
Tumor Cells ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Ascites Tumor ◽  
Ehrlich Ascites ◽  
Ehrlich Ascites Cells

Ehrlich ascites carcinoma cells in vitro converted extracellular hypoxanthine to extracellular inosine if uridine or guanosine was provided in the medium at the rate of 20–30 μmoles per milliliter of cells per hour. The synthesis of external uridine also took place when cells were incubated with uracil and a purine ribonucleoside, but at a lower rate than that of inosine. Intact Ehrlich ascites cells catalyzed an exchange between labelled uracil and uridine when both were present in the incubation medium.The synthesis of the extracellular ribonucleoside appeared to be mediated by ribonucleoside phosphorylases and to take place by the transfer of the ribosyl group from a donor ribonucleoside to an acceptor base.

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