THE LACK OF EFFECT OF VITAMIN E ON THE BLOOD CLOTTING MECHANISM

1954 ◽  
Vol 32 (1) ◽  
pp. 347-353
Author(s):  
Rachel M. Paul ◽  
J. A. Lewis ◽  
H. A. DeLuca
Keyword(s):  
Vitamin E ◽  
Oral Administration ◽  
Blood Clotting ◽  
Human Subjects ◽  
Plasma Fibrinogen ◽  
Platelet Level ◽  
Blood Change

The oral administration of vitamin E to human subjects in dail doses of 600 mgm. for seven days failed to evoke any blood change in clotting times, prothrombin times, or plasma fibrinogen levels. There was a small increase in platelet level which was statistically of borderline significance.

THE LACK OF EFFECT OF VITAMIN E ON THE BLOOD CLOTTING MECHANISM

1954 ◽  
Vol 32 (4) ◽  
pp. 347-353 ◽  
Author(s):  
Rachel M. Paul ◽  
J. A. Lewis ◽  
H. A. DeLuca
Keyword(s):  
Vitamin E ◽  
Oral Administration ◽  
Blood Clotting ◽  
Human Subjects ◽  
Plasma Fibrinogen ◽  
Platelet Level ◽  
Blood Change

The oral administration of vitamin E to human subjects in dail doses of 600 mgm. for seven days failed to evoke any blood change in clotting times, prothrombin times, or plasma fibrinogen levels. There was a small increase in platelet level which was statistically of borderline significance.

Observations on a Relationship between Steroid Metabolism and the Concentration of Plasma Fibrinogen

1963 ◽  
Vol 10 (02) ◽  
pp. 400-405 ◽  
Author(s):  
B. A Amundson ◽  
L. O Pilgeram
Keyword(s):  
Blood Coagulation ◽  
Methyl Ether ◽  
Broad Spectrum ◽  
Human Subjects ◽  
Plasma Fibrinogen ◽  
Steroid Metabolism ◽  
Specific Site ◽  
Chain Reaction ◽  
Normal Human ◽  
A Chain

SummaryEnovid (5 mg norethynodrel and 0.075 mg ethynylestradiol-3-methyl ether) therapy in young normal human subjects causes an increase in plasma fibrinogen of 32.4% (P >C 0.001). Consideration of this effect together with other effects of Enovid on the activity of specific blood coagulatory factors suggests that the steroids are exerting their effect at a specific site of the blood coagulation and/or fibrinolytic system. The broad spectrum of changes which are induced by the steroids may be attributed to a combination of a chain reaction and feed-back control.

scholarly journals Effect of Oral Administration of Selenium and Vitamin E on the Quality of Fresh, Refrigerated and Frozen Semen in French Bulldog Breed Dogs

2017 ◽  
Vol 45 (1) ◽  
pp. 7
Author(s):  
Marcelo George Mungai Chacur ◽  
Mariana Grandis Ripari de Souza ◽  
Camila Dutra de Souza ◽  
Camila Pires Cremasco
Keyword(s):  
Vitamin E ◽  
Citric Acid ◽  
Oral Administration ◽  
Liquid Nitrogen ◽  
Sperm Concentration ◽  
Oral Supplementation ◽  
Frozen Semen ◽  
French Bulldog ◽  
Fresh Semen

Background: New methodologies have been developed seeking to maximize pregnancy rate in female dogs created in commercial kennels, and also in order to maintain the quality of canine semen after dilution, refrigeration or freezing. One of the main factors that generate damage to sperm is oxidative stress, to minimize sperm damage, selenium and antioxidants like vitamin E are administered, by oral administration, seeking to improve the quality of semen. The objective was to study the effect of vitamin E and selenium, by oral administration, in the quality of fresh, refrigerated and frozen semen in adult dogs French Bulldog breed.Materials, Methods & Results: Semen samples were collected from 5 adult dogs, French Bulldog breed, being 2 semen drawing before the daily oral supplementation with vitamin E and selenium (ESE®) and semen drawing at 20, 40 and 60 days after the beginning of oral supplement. The ejaculated samples were diluted in TRIS - fructose citric acid (3.28 g TRIS-hydroxy-methyl-amino-methane, 1.78 g of citric acid monohydrate and 1.25 g of D - fructose, dissolved in 100 mL of distilled water and added of 20% egg yolk and 6% of glycerol. The characteristics evaluated in fresh semen were: volume (mL), color, appearance, concentration (x106 / mL), sperm motility (%), sperm strength (1 to 5) and morphology (%). For refrigerated and frozen semen were analyzed: sperm motility (%), sperm strength (1-5) and morphology (%). Diluted semen samples were centrifuged at: 1500 g/10 min and “pellets” formed by sperm of each ejaculated, detached from the tube wall were diluted homogeneously in the diluent TRIS type up to the final volume of 1.5 mL. After that, packaged in 0.5 mL French straws, kept under refrigeration at 5ºC/4 h, placed in nitrogen vapor at -120ºC/15 min, and dipped in liquid nitrogen at -196ºC and then stored on identified rachis and stored in liquid nitrogen container until the time of thawing in  water bath at 37°C/30 s for semen microscopic analysis. Data from fresh, refrigerated and frozen semen were statistically analyzed by analysis of variance and the average compared by 5% of Tukey test. Fresh semen sperm concentration differed (P < 0.05) between the samples, rising after 40 days after the beginning of oral supplementation with selenium and vitamin E. For the spermatic strength, better score (P < 0.05) was observed at collection 4, in 40 days after the beginning of oral supplementation to dogs. For fresh and refrigerated semen, the total defects, defects of head, acrosome and tail did not differ (P > 0.05) between the samples. Total sperm defects and minor head and tail defects did not differ (P > 0.05) between the samples in post-thawing. Regarding the acrosome defects after thawing, there was a significant reduction (P < 0.05) in samples performed 40 and 60 days after the beginning of oral supplementation with selenium and vitamin E.Discussion: Attention should be paid for what purpose the extenders within the refrigeration or freezing biotech will be used. The managed supplement, by oral administration, containing selenium and vitamin E, influenced beneficially raising the sperm concentration in fresh semen and decreasing the acrosome defects in frozen semen. Oral administration of supplementation with selenium and vitamin E is recommended for improving the quality of fresh and frozen semen in dogs.

Pharmacokinetics of Tenoxicam after oral administration in healthy human subjects of various single doses

1987 ◽  
Vol 12 (1) ◽  
pp. 59-63 ◽  
Author(s):  
R. J. Francis ◽  
J. G. Allen ◽  
D. Looi ◽  
J. S. Dixon ◽  
H. A. Bird ◽  
...  
Keyword(s):  
Oral Administration ◽  
Human Subjects ◽  
Healthy Human ◽  
Healthy Human Subjects

EFFECT OF THE ORAL ADMINISTRATION OF GLUCOSE UPON THE CONCENTRATION OF SERUM AMYLASE IN NORMAL ADULT HUMAN SUBJECTS

1949 ◽  
Vol 159 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Norman P. Goldstein ◽  
Benjamin W. Smith ◽  
Jerome H. Epstein ◽  
Joseph H. Roe
Keyword(s):  
Oral Administration ◽  
Serum Amylase ◽  
Human Subjects ◽  
Normal Adult ◽  
Adult Human

Relative Bioavailabilities of Natural and Synthetic Vitamin E Formulations Containing Mixed Tocopherols in Human Subjects

1999 ◽  
Vol 69 (2) ◽  
pp. 92-95 ◽  
Author(s):  
Chopra ◽  
Bhagavan
Keyword(s):  
Vitamin E ◽  
Animal Models ◽  
Human Subjects ◽  
Alpha Tocopherol ◽  
Tocopheryl Acetate ◽  
Normal Male ◽  
Gamma Tocopherol ◽  
Synthetic Vitamin ◽  
Male Subjects ◽  
Natural And Synthetic

There are several reports in the literature on the relative bioavailabilities of RRR (natural) vs. all-rac (synthetic) forms of vitamin E in humans and animal models but none on the bioavailability of alpha-tocopherol in mixed vitamin E formulations. In the present study we examined the bioavailability of alpha-tocopherol in a typical commercially available product containing mixed tocopherols. We also tested a formulation containing all-rac-alpha-tocopherol with mixed tocopherols for purposes of comparison along with straight RRR-and all-rac-alpha-tocopheryl acetate as reference products. Normal male subjects were given one of the four formulations of vitamin E (800 IU per day in softgel capsule form for 10 days): 1. All-rac-alpha-tocopheryl acetate, 2. RRR-alpha-tocopheryl acetate, 3. RRR-alpha-tocopherol with mixed tocopherols, and 4. all-rac-alpha-tocopherol with mixed tocopherols. Both serum alpha- and gamma-tocopherols were determined by HPLC at baseline, and at days 2, 4, 7 and 10. The values for alpha- at baseline and 10 days were 0.80, 0.80, 0.80 & 0.79 mg/dl and 1.67, 1.72, 1.76 & 1.62 mg/dl. The values for gamma- were 0.28, 0.29, 0.30 & 0.29 mg/dl and 0.11, 0.08, 0.10 & 0.10 mg/dl. Thus the data show that a) the bioavailability of RRR-and all-rac-alpha-tocopherols is not affected by other tocopherols, and b) both RRR-and all-rac-alpha-tocopherol (free or esterified) significantly suppress the serum gamma tocopherol to the same extent. Furthermore, since there was no difference in the serum values of alpha-tocopherol between RRR-and all-rac-vitamin E given the same dose as IUs, the data also support the currently accepted ratio of 1.36 for the biopotency of RRR- vs. all-rac-alpha-tocopheryl acetate.

scholarly journals Sustained Release of Phenytoin Following the Oral Administration of Phenytoin Sodium/Ethylcellulose Microcapsules in Human Subjects and Rabbits.

1994 ◽  
Vol 17 (3) ◽  
pp. 432-436 ◽  
Author(s):  
Ikuko KARAKASA ◽  
Naomi YAGI ◽  
Megumi SHIBATA ◽  
Harumi KENMOTSU ◽  
Hitoshi SEKIKAWA ◽  
...  
Keyword(s):  
Sustained Release ◽  
Oral Administration ◽  
Human Subjects ◽  
Phenytoin Sodium

Assessment of vitamin E concentrations in serum and cerebrospinal fluid of horses following oral administration of vitamin E

2008 ◽  
Vol 69 (6) ◽  
pp. 785-790 ◽  
Author(s):  
Jamie K. Higgins ◽  
Birgit Puschner ◽  
Philip H. Kass ◽  
Nicola Pusterla
Keyword(s):  
Cerebrospinal Fluid ◽  
Vitamin E ◽  
Oral Administration
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