Synergistic anti-Newcastle disease virus activity of pokeweed antiviral protein, ribavirin, and guanidine

1998 ◽  
Vol 44 (7) ◽  
pp. 702-705 ◽  
Author(s):  
Eric Weaver ◽  
Gary M Aron
Keyword(s):  
Newcastle Disease Virus ◽  
Key Words ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Pokeweed Antiviral Protein ◽  
Antiviral Protein ◽  
Virus Activity

Pokeweed antiviral protein (PAP), in combination with either guanidine or ribavirin, exhibited both synergy and antagonism toward the replication of Newcastle disease virus. Low, medium, and high effective concentrations of both PAP and guanidine were synergistic when used in combination. High effective concentrations of ribavirin in combination with PAP were antagonistic, whereas low and medium effective concentrations were synergistic. Key words: pokeweed antiviral protein, Newcastle disease virus, ribavirin, guanidine, synergy.

scholarly journals STUDIES ON NEWCASTLE DISEASE VIRUS

1948 ◽  
Vol 88 (2) ◽  
pp. 233-240 ◽  
Author(s):  
F. B. Bang
Keyword(s):  
Newcastle Disease Virus ◽  
Red Blood Cells ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Blood Cells ◽  
Embryo Mortality ◽  
Consistent Effect ◽  
Virus Activity ◽  
Routine Handling

The application of the 50 per cent embryo mortality to a study of the virus of Newcastle is described. It has been evaluated by a series of duplicate titrations of the same sample of virus. In seven such titrations the largest difference between the two was 10–0.4. It is therefore believed that a difference of 0.6 log is probably significant and of 1.0 log almost certainly significant. This would mean that we can almost certainly detect a loss of 90 per cent of activity. Neither temperature of incubation nor route of inoculation in the test embryos had consistent effect on the measurement of virus activity. The effect of increasing age of the incubated embryo, from 10 days up to 16 days, is slight and inconsistent. The addition of chicken red blood cells to a dilution of virus may lower the titer of the preparation, but the change is not sufficient to be of importance in the routine handling of the virus.

Characterization of Recent Isolates of Newcastle Disease virus

2016 ◽  
Vol 21 (1) ◽  
pp. 235-248
Author(s):  
Amani Saleh ◽  
Rola Ali ◽  
Mohamed Fawzy ◽  
Mokhtar Eltarabily
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease

Transcription and translation of Newcastle disease virus mRNA's in vitro.

1978 ◽  
Vol 28 (1) ◽  
pp. 324-336 ◽  
Author(s):  
P L Collins ◽  
L E Hightower ◽  
L A Ball
Keyword(s):  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease
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