Enzymes in organic synthesis. 37. Preparation and characterization of potential decalindione substrates of horse liver alcohol dehydrogenase

1987 ◽  
Vol 65 (10) ◽  
pp. 2397-2404 ◽  
Author(s):  
J. Bryan Jones ◽  
David R. Dodds
Keyword(s):  
Alcohol Dehydrogenase ◽  
Organic Synthesis ◽  
Horse Liver Alcohol Dehydrogenase ◽  
Liver Alcohol Dehydrogenase ◽  
Horse Liver ◽  
Enzymes In Organic Synthesis

The preparations of ten decalindiones for investigation as substrates of horse liver alcohol dehydrogenase are reported. The structure characterizations include clarifications of some ambiguities in the decalin literature.

Enzymes in organic synthesis. 32. Stereospecific horse liver alcohol dehydrogenase-catalyzed oxidations of exo- and endo-oxabicyclic meso diols

1984 ◽  
Vol 62 (11) ◽  
pp. 2578-2582 ◽  
Author(s):  
J. Bryan Jones ◽  
Christopher J. Francis
Keyword(s):  
Alcohol Dehydrogenase ◽  
Organic Synthesis ◽  
Horse Liver Alcohol Dehydrogenase ◽  
Preparative Scale ◽  
Enantiomerically Pure ◽  
Liver Alcohol Dehydrogenase ◽  
Horse Liver ◽  
One Step ◽  
Catalyzed Oxidation ◽  
Enzymes In Organic Synthesis

Preparative-scale horse liver alcohol dehydrogenase-catalyzed oxidation of mesoexo- and endo-7-oxabicyclo[2.2.1]heptane diols provides a direct one-step route to enantiomerically pure chiral γ-lactones of the oxabicyclic series.

Enzymes in organic synthesis. 23. Effects of organic solvents on horse liver alcohol dehydrogenase-catalyzed oxidation

1982 ◽  
Vol 60 (8) ◽  
pp. 1030-1033 ◽  
Author(s):  
J. Bryan Jones ◽  
Harold M. Schwartz
Keyword(s):  
Alcohol Dehydrogenase ◽  
Organic Synthesis ◽  
Organic Solvents ◽  
Butyl Alcohol ◽  
Horse Liver Alcohol Dehydrogenase ◽  
Liver Alcohol Dehydrogenase ◽  
Tert Butyl Alcohol ◽  
Horse Liver ◽  
Catalyzed Oxidation ◽  
Enzymes In Organic Synthesis

The effects have been evaluated of up to 50% (v/v) of methanol, tert-butyl alcohol, dimethylsulfoxide, sulfolane, acetonitrile, dimethylformamide, N-methyl-2-pyrrolidone, hexamethylphosphoramide, acetone, 2-butanone, tetrahydrofuran, dimethoxyethane, diglyme, and dioxane on horse liver alcohol dehydrogenase (HLADH)-catalyzed oxidation of the representative alcohol substrate cyclohexanol. With the exception of dimethylsulfoxide and dimethylformamide, all solvents tested are suitable for use as cosolvents with HLADH in the oxidative and reductive directions.

Enzymes in organic synthesis. 22. Effects of organic solvents on horse liver alcohol dehydrogenase-catalyzed reduction

1982 ◽  
Vol 60 (3) ◽  
pp. 335-338 ◽  
Author(s):  
J. Bryan Jones ◽  
Harold M. Schwartz
Keyword(s):  
Alcohol Dehydrogenase ◽  
Organic Synthesis ◽  
Organic Solvents ◽  
Horse Liver Alcohol Dehydrogenase ◽  
Liver Alcohol Dehydrogenase ◽  
Horse Liver ◽  
Enzymes In Organic Synthesis

The effects have been evaluated of up to 30% (v/v) of methanol, ethanol, 2-propanol, tert-butylalcohol, dimethylsulfoxide, sulfolane, acetonitrile, dimethylformamide, N-methyl-2-pyrrolidone, hexamethylphosphoramide, tetrahydrofuran, dimethoxymethane, diglyme, and dioxane on horse liver alcohol dehydrogenase-catalyzed reduction of the representative ketone cyclohexanone. The most viable solvents are those shown in italics on the above list.

Sign in / Sign up

Export Citation Format

Share Document