Structure et conformation du complexe du N-acétyl-aspartate avec un cation lanthanide. Étude par résonance magnétique nucléaire du 1H et du 13C

1986 ◽  
Vol 64 (7) ◽  
pp. 1267-1277 ◽  
Author(s):  
Daniel Baron ◽  
Nicole Lumbroso-Bader
Keyword(s):  
Nitrogen Atom ◽  
Axial Symmetry ◽  
Binding Constant ◽  
Contact Term ◽  
Lanthanide Induced Shifts ◽  
Résonance Magnétique ◽  
Geometrical Factors ◽  
A Minor ◽  
Main Factor

Lanthanide induced shifts by Lu3+, Yb3+, Tm3+, Er3+, Ho3+, and Dy3+ in NAcAsp (0.14 M in D2O, pH 5) are observed for ten magnetic sites (1H and 13C). The averaged binding constant for 1:1 complexes is 72 M−1 (for chloride solutions of ca. 0.05 M). Determination of the pseudo-contact geometrical factors (under axial symmetry approximation) requires taking into account a contact term and discarding the Tm3+ results. Data from the Asp residue are in agreement with 6 structures of this residue such that chelation occurs through the two carboxylates. Oβ−… Cα′ length seems to be the main factor while COOα− orientation is a minor one. The entire set of results is consistent with only three structures where the nitrogen atom is far from the carboxylates, and the Cα—N rotamers have extended conformations. Three oxygen atoms (two from the COOβ− group) appear to be involved in the chelation. However, the data do not exclude another minor conformational species.

Features of the course of birth in northern domestic deer in the conditions of the North-East of Russia (Yakutia)

2021 ◽  
pp. 23-28
Author(s):  
V. Fedorov ◽  
T. Ippolitova ◽  
E. Sleptsov ◽  
K. Plemyashov
Keyword(s):  
Living Environment ◽  
Behavioral Reactions ◽  
Climatic Zones ◽  
North East ◽  
The North ◽  
The Republic ◽  
A Minor ◽  
Harsh Conditions ◽  
Generic Process

Purpose: Determination of the peculiarities of the behavior and the flow of childbirth in females (wrenches) of the northern home deer of the Even Breed of the Republic of Sakha (Yakutia), depending on the natural climatic zone of breeding.Material and research methods. Research of the reservation of the hotel's reservoir of the northern home deer was held from April to June in the reindeer herds of the mountain-taiga (FSUE «Yuchjuyuskoye») and the Tundrov zones (SHPZK «Taba-Yana») of the Republic of Sakha (Yakutia) in the conditions of nomadic home reindeer herding since 2013 2018 In the study, the method of observation is used with the registration of motor activity of animals and the activities of individual bodies in a certain living environment.Results. To fix some patterns and species features of the generic process, 8 main elementary behavioral reactions spent venizables of northern domestic deer per day before childbirth: walking, feeding feed, chewing, leisure standing, rest lying, sleep, urination (how many times / total time), defecation (how many times / total time). Also marked 4 behavioral reactions on the hotel day: the exploitation time of the fetus, the licking of the calf, the time of the calf on his feet after delivery, the first reception of the mosper calf after birth. For each parameter, data reflected in tabular format is obtained.Conclusion. It has been established that the degree of adaptation of the northern domestic deer to the harsh conditions of existence in various natural-climatic zones of the Republic of Sakha (Yakutia) is very high, which is manifested in a minor difference in the duration of the generic process and behavioral reactions at the vainer of the mountain and tundra and tundra dilution zones.

Isolation of radioactive iodothyronines for kinetic studies: a comparison of two methods

1982 ◽  
Vol 99 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Jens Faber ◽  
lb Bo Lumholtz ◽  
Carsten Kirkegaard ◽  
Kaj Siersbæk-Nielsen ◽  
Thorkild Friis
Keyword(s):  
Radioactive Iodine ◽  
Single Injection ◽  
Kinetic Studies ◽  
Acid Precipitation ◽  
Relative Difference ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate ◽  
Minor Degree ◽  
A Minor

Abstract. A method based on the principle of gel separation followed by antibody extraction (GSAE) has been developed for isolation of radioactive thyroxine (T4), 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3), 3,3'-diiodothyronine (3,3'-T2), 3',5'-diiodothyronine (3',5'-T2) and 3'-monoiodothyronine (3'-T1) in serum. This method was used for the estimation of the metabolic clearance rate (MCR) of the iodothyronines using the single injection, non-compartmental approach, and was compared to the conventional trichloroacetic acid precipitation/ethanol extraction (TCA-E) technique. The GSAE method excluded the co-determination of radioactive iodine and iodoproteins, whereas the co-determination of radiolabelled daughter iodothyronines was found negligible. The relative difference of duplicate estimations of MCR was approximately 10%. Using the TCA-E method for isolation of tracer, the MCR of T4, T3 and rT3 was underestimated to a minor degree (20%), whereas the MCRs of 3,3'-T2, 3',5'-T2 and 3'-T1 were 20–40% of those estimated by the GSAE method. In conclusion the GSAE method was found suitable for kinetic studies of iodothyronines, whereas the TCA-E method cannot be used for turnover studies of 3,3'-T2, 3',5'-T2 or 3'-T1.

scholarly journals PHYSICAL-CHEMICAL FORMATION CONDITIONS OF URANIUM-TITANIUM-METAGEL MINERALIZATION AT THE GOLD-URANIUM ELKON DEPOSIT

2017 ◽  
pp. 52-57 ◽  
Author(s):  
M. M. Komarova ◽  
VL. B. Komarov ◽  
A. P. Aleshin ◽  
T. L. Krylova
Keyword(s):  
Crystalline Form ◽  
Fluid Regime ◽  
Ore Formation ◽  
Physical Chemical ◽  
Wide Range ◽  
Moderate Salinity ◽  
Formation Conditions ◽  
Carbonate Composition ◽  
Main Factor

A wide range of the temperatures of hydrothermal fluid regime (430-103 °C) has been revealed in the result of microthermometric study of the fluid inclusions in the minerals of pre-ore and post-ore stages developed at the Elkon deposit. Average temperatures, as well as the temperature variation are similar for both pre-ore and post-ore stages. It allows sure determination of temperatures of uranium ore formation as 400-120 °C. Fluids possessed Na-chloride, rarely Na-chloride-carbonate composition and moderate salinity (6-16 wt. % · NaCl equiv.). The wide range of tem-peratures confirms an assumption made before that various temperatures were the reason of formation of uranium mineralization both in the form of predominantly amorphous phase (U-Ti-metagel), as well as the rarely crystalline form (brannerite). Abrupt temperature decrease was apparently the main factor of the ore precipitation.

scholarly journals Analisis Pertumbuhan Ekonomi Provinsi Jambi 2012-2019

2020 ◽  
Vol 4 (2) ◽  
pp. 85
Author(s):  
M Yunus ◽  
Novi Mubyarto ◽  
Robi Agustin
Keyword(s):  
Economic Growth ◽  
Economic Activity ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Coefficient Of Determination ◽  
Advantages And Disadvantages ◽  
The Earth ◽  
Growth Economic ◽  
Main Factor

The development achievement of an economic activity can be measured by economic growth. Economic growth will improve if there are activities carried out by humans for the prosperity of the earth and their prosperity. An important factor for increasing economic growth is international trade, one of which is exports. Allah SWT has created in every region and country the advantages and disadvantages. The main factor that also has an influence on the economic development of a country / region is investment activities. Regarding investment in the Al Qur’an, it is clearly stated that investing is a way that is ordered by Allah SWT not to leave the weak generation. In this study, an analysis of the economic growth of the province of Jambi was conducted in 2012-2019. The method used is multiple linear regression analysis. Based on the results of using the R application, there is a significant influence between the export variable and the investment variable on the economic growth variable. The modeling results obtained are Y = 5848.0543 + 0.8886X1 + 0.7929X2. Every increase in exports of 1 billion and investment is considered constant, it will increase economic growth by 0.8886 billion. Every increase in investment of 1 billion and exports are considered constant, it will increase economic growth by 0.7929 billion. The coefficient of determination of 94.06 percent means that the diversity of economic growth variables can be explained by the export and the investment, the remaining 5.94% is explained by other variables not included in the regression model.

scholarly journals Regional features of innovative development and differentiation of directions of innovation policy of Russia

2021 ◽  
Vol 9 (3-4) ◽  
pp. 121-132
Author(s):  
Alexander Dubovitski ◽  
Elvira Klimentova ◽  
Matvei Rogov
Keyword(s):  
Innovation Policy ◽  
Group Analysis ◽  
Innovative Development ◽  
Innovation Development ◽  
Homogeneous Groups ◽  
Regional Features ◽  
Development And Differentiation ◽  
Main Factor ◽  
Average Average

In our manuscript we have made an attempt to study specific sides of Russian Federation's innovative development, analyze its impact in economy growth and provide main ways of innovative policy realization in different types of regions. The method is based on partial abstraction from the unique properties of each region, thereby uniting them into homogeneous groups using k-means method. Further analysis of the determination of the main factor at the level of country was carried out using decision trees functions with the subsequent collection of OOB errors. Group analysis was carried out using regression analysis. As a result, the authors obtained five types of regions (with a high, above average, average, below average, low level of innovative development), provided an individual characteristic for each group regarding the innovation development and identified prerogative innovative factors that can be considered by the state as a criterion for differentiating state policy and regulation of the development of innovation policy.

The First Direct Determination of a Ligand Binding Constant in Protein Crystals

2001 ◽  
Vol 113 (3) ◽  
pp. 602-606 ◽  
Author(s):  
Su-ying Wu ◽  
Jacqueline Dornan ◽  
George Kontopidis ◽  
Paul Taylor ◽  
Malcolm D. Walkinshaw
Keyword(s):  
Ligand Binding ◽  
Binding Constant ◽  
Direct Determination ◽  
Protein Crystals

Accuracy in phase determination of LP electromagnetic seismographs based on transient calibration pulse

1976 ◽  
Vol 66 (1) ◽  
pp. 97-104 ◽  
Author(s):  
W. Mitronovas
Keyword(s):  
Least Squares ◽  
Large Error ◽  
Phase Response ◽  
Additional Parameter ◽  
Origin Time ◽  
Pulse Inversion ◽  
Transient Calibration ◽  
A Minor ◽  
Typical Solution

abstract A modification of the Jarosch and Curtis (1973) formulation for the calibration pulse inversion is suggested in an effort to improve its accuracy. The modification involves the introduction of the origin time of the pulse (time of the step in the calibration current) as an additional parameter to be solved in the least-squares inversion. This approach is found to be not completely satisfactory in general, but does improve the solution when a large error in origin time (> ±0.5 sec) is introduced in digitizing the pulse. A typical solution, when the origin time of the pulse has to be determined by least-squares, is accurate to within ± 1 sec in the phase response of a system for periods up to 500 sec. A more satisfactory approach is to record the origin time of calibration pulses on seismograms. Only a minor modification of the existing calibration circuit is necessary to provide a simultaneous signal to a time relay and calibration coil through a double pole switch. For pulses, where the origin time is known accurately, the existing techniques give results accurate to within ± 0.3 sec in phase response.

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