4-Iodophenylcholine: a potential myocardial imaging agent

1984 ◽  
Vol 62 (10) ◽  
pp. 2015-2018 ◽  
Author(s):  
Duncan H. Hunter ◽  
Yolanda Zea Ponce ◽  
G. William Brown ◽  
Michael J. Chamberlain ◽  
Albert A. Driedger ◽  
...  
Keyword(s):  
Diazonium Salt ◽  
Imaging Agent ◽  
Myocardial Imaging ◽  
Post Injection ◽  
Iodine 131 ◽  
Radiochemical Yields ◽  
Iodine 125

The compound O-(4-iodophenyl)choline iodide has been synthesized using iodine-125, iodine-127, and iodine-131 by diazonium salt and melt exchange procedures. Radiochemical yields of approximately 2% and 56%, respectively, were obtained. The biodistribution of this compound in mice was analyzed in order to determine its potential as a myocardial imaging agent. Selective myocardial concentration was observed at 5 min post-injection, with a heart-to-blood ratio of 18:1.

Thallium-201 as a myocardial imaging agent

1977 ◽  
Vol 7 (1) ◽  
pp. 49-58 ◽  
Author(s):  
H. William Strauss ◽  
Bertram Pitt
Keyword(s):  
Thallium 201 ◽  
Imaging Agent ◽  
Myocardial Imaging

Technetium-99m isonitrile complex as a potential myocardial imaging agent

1985 ◽  
Vol 6 (10) ◽  
pp. 615-622 ◽  
Author(s):  
M. N. KHALIL ◽  
J. THORNBACK ◽  
M. Y. EARLY ◽  
D. B. MORTON ◽  
J. M. BERRY ◽  
...  
Keyword(s):  
Imaging Agent ◽  
Myocardial Imaging ◽  
Technetium 99M

scholarly journals Protection by DMSO against Cell Death Caused by Intracellularly Localized Iodine-125, Iodine-131 and Polonium-210

2000 ◽  
Vol 153 (4) ◽  
pp. 416-427 ◽  
Author(s):  
Anupam Bishayee ◽  
Dandamudi V. Rao ◽  
Lionel G. Bouchet ◽  
Wesley E. Bolch ◽  
Roger W. Howell
Keyword(s):  
Cell Death ◽  
Iodine 131 ◽  
Iodine 125

Scintigraphic evaluation of glomus tumours

1990 ◽  
Vol 104 (1) ◽  
pp. 33-36 ◽  
Author(s):  
T. A. Rockall ◽  
J. C. Watkinson ◽  
S. E. M. Clark ◽  
E. E. Douek
Keyword(s):  
Head And Neck ◽  
Medullary Carcinoma ◽  
Imaging Agent ◽  
Glomus Tumour ◽  
Tumour Imaging ◽  
Radionuclide Scintigraphy ◽  
Iodine 131 ◽  
Magnetic Resonance Imaging Mri ◽  
Anatomical Information ◽  
Ct And Mri

AbstractThe current investigations of choice for a suspected glomus tumour are either direct or indirect angiography to include digital subtraction followed by computerized tomography (CT) or magnetic resonance imaging (MRI) or, if available, CT and MRI with gadolinium alone. Although these modalities confirm the diagnosis and give anatomical information to facilitate accurate staging, they do not provide functional data. The use of radionuclide scintigraphy can add an extra physiological dimension to glomus tumour imaging.Iodine-131/123 metaiodobenzylguanidine (MIBG) is a tumour imaging agent which has been used to diagnose head and neck neuroendocrine tumours to include paragangliomata and medullary carcinoma of the thyroid (MCT). However, it is expensive and the new head and neck tumour imaging agent technetium-99 m (Tc99m) (v) dimercaptosuccinic acid (DMSA) has superceded it as the imaging agent of choice to evaluate MCT. We report a patient with a glomus jugulare tumour which was evaluated with I131/I123-MIBG and Tc99m (v) DMSA. The tumour was functional and is the first reported case exhibiting positive accumulation of both I131-MIBG and Tc99m (v) DMSA. The patient was subsequently treated with a therapeutic dose of I131-MIBG. The significance of these results is discussed.

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