A total synthesis of the enantiomer of anhydromyriocin (anhydrothermozymocidin)

1981 ◽  
Vol 59 (2) ◽  
pp. 269-282 ◽  
Author(s):  
Daniel R. Payette ◽  
George Just
Keyword(s):  
Antifungal Activity ◽  
Total Synthesis ◽  
Absolute Configuration ◽  
Optical Antipode ◽  
The Absolute ◽  
Natural Enantiomer

The optical antipode of anhydromyriocin, the γ-lactone derived from the antibiotic myriocin (thermozymocidin), was synthesized from L-arabinose, establishing the absolute configuration of myriocin as 47. In contrast to its natural enantiomer, it showed but little antifungal activity.

Asymmetric Total Synthesis and Determination of the Absolute Configuration of (+)-Srilankenyne via Sequence-Sensitive Halogenations Guided by Conformational Analysis

2021 ◽  
Vol 23 (4) ◽  
pp. 1321-1326
Author(s):  
Hongjun Jang ◽  
Soo Yeon Kwak ◽  
Dongjoo Lee ◽  
Juan V. Alegre-Requena ◽  
Hyoungsu Kim ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Conformational Analysis ◽  
Absolute Configuration ◽  
Asymmetric Total Synthesis ◽  
The Absolute

Total synthesis and determination of the absolute configuration of (−)-longilene peroxide

2001 ◽  
Vol 42 (36) ◽  
pp. 6307-6309 ◽  
Author(s):  
Yoshiki Morimoto ◽  
Toshiyuki Iwai ◽  
Takamasa Kinoshita
Keyword(s):  
Total Synthesis ◽  
Absolute Configuration ◽  
The Absolute

(-)-Strempeliopine, stereoselective total synthesis and the determination of absolute configuration

1986 ◽  
Vol 51 (8) ◽  
pp. 1731-1742 ◽  
Author(s):  
Josef Hájíček ◽  
Jan Trojánek
Keyword(s):  
Circular Dichroism ◽  
Total Synthesis ◽  
Absolute Configuration ◽  
Determination Of Absolute Configuration ◽  
Natural Base ◽  
The Absolute ◽  
Circular Dichroïsm

A synthesis of (±)-strempeliopine (II) is described, the key step of which is the stereoselective reductive rearrangement of 18-methylene-1,2-dehydroaspidospermidine (XI). The absolute configuration of the natural (-)-base II was determined as (2S, 7R, 20R, 21R) on the basis of its synthesis from (+)-18-methylenevincadifformine (XVII) the configuration of which was derived from a comparison of circular dichroism properties of bases with a β-anilinoacrylate chromophore. The biogenesis of the alkaloids of the schizozygane type is discussed.

First Total Synthesis and Determination of the Absolute Configuration of Strictifolione, a New 6-(ω-Phenylalkenyl)-5,6-dihydro-α-pyrone, Isolated from Cryptocarya strictifolia.

ChemInform ◽  
2003 ◽  
Vol 34 (7) ◽  
Author(s):  
Lia Dewi Juliawaty ◽  
Yoshimi Watanabe ◽  
Mariko Kitajima ◽  
Sjamsul Arifin Achmad ◽  
Hiromitsu Takayama ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Absolute Configuration ◽  
The Absolute

ChemInform Abstract: Total Synthesis and Determination of the Absolute Configuration of FD-838, a Naturally Occurring Azaspirobicyclic Product.

ChemInform ◽  
2009 ◽  
Vol 40 (47) ◽  
Author(s):  
Yujiro Hayashi ◽  
Kuppusamy Sankar ◽  
Hayato Ishikawa ◽  
Yuriko Nozawa ◽  
Kazutoshi Mizoue ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Absolute Configuration ◽  
Naturally Occurring ◽  
The Absolute

Chemoenzymatic total synthesis and determination of the absolute configuration of (S)-nebracetam

2008 ◽  
Vol 19 (18) ◽  
pp. 2115-2118 ◽  
Author(s):  
Sho Yamashita ◽  
Nobuyuki Mase ◽  
Kunihiko Takabe
Keyword(s):  
Total Synthesis ◽  
Absolute Configuration ◽  
The Absolute
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