Reactions of Keten Acetals. Part I. A Simple Synthesis of Some Naturally Occurring Anthraquinones

1974 ◽  
Vol 52 (1) ◽  
pp. 80-87 ◽  
Author(s):  
Jacques Banville ◽  
Jean-Louis Grandmaison ◽  
Gérard Lang ◽  
Paul Brassard
Keyword(s):  
Simple Synthesis ◽  
Naturally Occurring ◽  
One Step ◽  
Phthalic Anhydrides

A study of the condensation of keten acetals with some halonaphthoquinones has led to the simple and regiospecific synthesis of some naturally occurring anthraquinones: catenarin, helminthosporin, emodin, and chrysophanol. The results show unambiguously that a previously proposed mechanism is erroneous. The reaction of these acetals with chloromaleic anhydride also provided a one-step preparation of some substituted phthalic anhydrides.

A Simple Synthesis of the Anticancer Drug Altretamine

2020 ◽  
Vol 17 (8) ◽  
pp. 628-630
Author(s):  
Vu Binh Duong ◽  
Pham Van Hien ◽  
Tran Thai Ngoc ◽  
Phan Dinh Chau ◽  
Tran Khac Vu
Keyword(s):  
Aqueous Solution ◽  
Anticancer Drug ◽  
Potassium Hydroxide ◽  
Large Scale ◽  
Synthesis Method ◽  
Practical Method ◽  
Cyanuric Chloride ◽  
Simple Synthesis ◽  
High Yield ◽  
One Step

A simple and practical method for the synthesis on a large scale of altretamine (1), a wellknown antitumor drug, has been successfully developed. The synthesis method involves the conversion of cyanuric chloride (2) into altretamine (1) by dimethylamination of 2 with an aqueous solution of 40% dimethylamine and potassium hydroxide in 1, -dioxan 4in one step to give altretamine (1) in high yield.

scholarly journals Exploiting the Amazing Diversity of Natural Source-Derived Polysaccharides: Modern Procedures of Isolation, Engineering, and Optimization of Antiviral Activities

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 136
Author(s):  
Bimalendu Ray ◽  
Martin Schütz ◽  
Shuvam Mukherjee ◽  
Subrata Jana ◽  
Sayani Ray ◽  
...  
Keyword(s):  
Structural Characteristics ◽  
Antiviral Drug ◽  
Natural Source ◽  
Target Interaction ◽  
Charge Densities ◽  
Linkage Pattern ◽  
Naturally Occurring ◽  
Antiviral Activities ◽  
One Step

Naturally occurring polysaccharide sulfates are highly diverse, owning variations in the backbone structure, linkage pattern and stereochemistry, branching diversity, sulfate content and positions of sulfate group(s). These structural characteristics bring about diverse sulfated polymers with dissimilar negative charge densities and structure–activity relationships. Herein, we start with a short discussion of techniques needed for extraction, purification, chemical sulfation, and structural characterization of polysaccharides. Processes of isolation and sulfation of plant-derived polysaccharides are challenging and usually involve two steps. In this context, we describe an integrated extraction-sulfation procedure that produces polysaccharide sulfates from natural products in one step, thereby generating additional pharmacological activities. Finally, we provide examples of the spectrum of natural source-derived polysaccharides possessing specific features of bioactivity, in particular focusing on current aspects of antiviral drug development and drug–target interaction. Thus, the review presents a detailed view on chemically engineered polysaccharides, especially sulfated derivatives, and underlines their promising biomedical perspectives.

scholarly journals Simple synthesis of ZnO nanoparticles on N-doped reduced graphene oxide for the electrocatalytic sensing of l-cysteine

RSC Advances ◽  
2017 ◽  
Vol 7 (56) ◽  
pp. 35004-35011 ◽  
Author(s):  
Suling Yang ◽  
Gang Li ◽  
Chen Qu ◽  
Guifang Wang ◽  
Dan Wang
Keyword(s):  
Graphene Oxide ◽  
Low Temperature ◽  
Reduced Graphene Oxide ◽  
Zno Nanoparticles ◽  
Low Cost ◽  
Hydrothermal Process ◽  
Simple Synthesis ◽  
Zno Nanoparticle ◽  
Reduced Graphene ◽  
One Step

A new kind of ZnO nanoparticle/N-doped reduced graphene oxide nanocomposite (ZnONPs/N-rGO) was synthesized through a low temperature, low-cost and one step hydrothermal process.

scholarly journals Green resins from renewable resources

2021 ◽  
Author(s):  
Justin J. Kosalka
Keyword(s):  
Phenolic Compounds ◽  
High Resolution Mass Spectrometry ◽  
Dicarboxylic Acids ◽  
13C Nmr Spectroscopy ◽  
One Pot ◽  
1H And 13C Nmr ◽  
X Ray Crystallography ◽  
Naturally Occurring ◽  
One Step ◽  
Acid Catalyzed

This work was aimed at exploring bio-based materials for the purpose of toner production on an industrial scale. Polyester and polyether based resins were prepared in good yields from naturally occurring phenolic compounds with desired thermal and physical properties. Phenols with varying functionality such as guaiacol, eugenol and vanillin along with two synthetically produced phenolic compounds modelling the β-O-4 linkage found in softwood lignins were explored as suitable precursors to synthetic, "green", resins. Phenols were transformed into diols using glycerine carbonate and a base catalyzed reaction. Diols were then polymerized with dicarboxylic acids in an acid catalyzed, transesterfication, reaction. A novel, bio-based polyether was synthesized in one pot, one step polymerization using vanillin. Thermal properties ((Tg) and (Ts) of resulting resins were evaluated. Resulting compounds and polymers were characterized using 1H and 13C NMR spectroscopy, high resolution mass spectrometry, elemental analysis, X-ray crystallography, DSC and GPC.

One-pot green and simple synthesis of actinian nickel-doped carbon nanoflowers for ultrasensitive sensing of quercetin

The Analyst ◽  
2019 ◽  
Vol 144 (24) ◽  
pp. 7283-7289 ◽  
Author(s):  
Yuan-Fei Gao ◽  
Xing Jin ◽  
Fen-Ying Kong ◽  
Zhong-Xia Wang ◽  
Wei Wang
Keyword(s):  
Hydrothermal Method ◽  
Simple Synthesis ◽  
One Pot ◽  
One Step

In this contribution, highly fluorescent actinian nickel-doped carbon nanoflowers were successfully synthesized by one-step traditional hydrothermal method and allowed the analysis of quercetin in a very facile method.

A simple synthesis of oxazolidinones in one step from carbon dioxide

1990 ◽  
Vol 31 (12) ◽  
pp. 1721-1722 ◽  
Author(s):  
Jan Fournier ◽  
Christian Bruneau ◽  
Pierre H. Dixneuf
Keyword(s):  
Carbon Dioxide ◽  
Simple Synthesis ◽  
One Step

ChemInform Abstract: An Easy One-Step Synthesis of Imidazolin-2-ones from Phthalic Anhydrides and Their Antioxidant Evaluation.

ChemInform ◽  
2016 ◽  
Vol 47 (24) ◽  
Author(s):  
Hector S. Lopez ◽  
Jose E. Enciso ◽  
Adrian Ochoa-Teran ◽  
Juan I. Velazquez ◽  
Juan I. Sarmiento
Keyword(s):  
Antioxidant Evaluation ◽  
One Step ◽  
Phthalic Anhydrides
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