The Constituents of Naucleadiderrichii. Part III. Indole-Pyridine Alkaloids

1972 ◽  
Vol 50 (10) ◽  
pp. 1486-1495 ◽  
Author(s):  
D. G. Murray ◽  
A. Szakolcai ◽  
Stewart McLean
Keyword(s):  
Spectroscopic Techniques ◽  
The Novel ◽  
Working Hypothesis ◽  
Spectroscopic Characteristics ◽  
Form Ring

Six alkaloids isolated from the bark of Naucleadiderrichii have been shown to have structures that contain both indole and pyridine units. Because of the small amounts available of each constituent, investigation of structure has been confined mainly to the application of spectroscopic techniques; these have shown that all of these alkaloids belong to the novel indole-pyridine class, and have led us to propose structures or part structures with varying degrees of confidence for each of the alkaloids. Structure 1 was deduced for naucledine, C18H15N3O2, and confirmed by synthesis. Its spectroscopic characteristics indicate that nauclederine, C19H19N3O2, has structure 3, but this has not yet been confirmed by synthesis. Evidence is presented that nauclechine, C21H21N3O3, has part structures 6 and 7, and it is suggested that these can be incorporated in structure 8. A working hypothesis for the structure of nauclexine, C18H17N3O2, is represented by 9. Two alkaloids, ND-363C, C21H21N3O3, and ND-305B, C19H19N3O, are closely related, the latter being formally derived from the former by removal of a carbomethoxy group; each appears to exist as an equilibratible pair of isomers containing an indolic (substituted β-carboline) and a pyridine part linked together in a manner which may incorporate a spiro carbinolamine ether (as in 12) that can form ring-opened or solvated derivatives in some solvents.

scholarly journals Tetramer Compound of Manganese Ions with Mixed Valence [MnII MnIII MnIV] and Its Spatial, Electronic, Magnetic, and Theoretical Studies

Crystals ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. 447 ◽  
Author(s):  
Cándida Pastor-Ramírez ◽  
Rafael Ulloa ◽  
Daniel Ramírez-Rosales ◽  
Hugo Vázquez-Lima ◽  
Samuel Hernández-Anzaldo ◽  
...  
Keyword(s):  
Mixed Valence ◽  
Magnetic Behavior ◽  
Local Geometry ◽  
Spectroscopic Techniques ◽  
Theoretical Studies ◽  
The Novel ◽  
Manganese Ions ◽  
Computational Calculations ◽  
Valence Electrons ◽  
Coordination Reaction

Using different spectroscopic techniques and computational calculations, we describe the structural and electromagnetic relationship that causes many interesting phenomena within a novel coordination compound with mixed valence manganese (II, III and IV) in its crystal and powder state. The novel compound [MnII MnIII MnIV(HL)2(H2L)2(H2O)4](NO3)2(H2O) 1 was obtained with the Schiff base (E)-2-((2-hydroxybenzylidene)amine)-2-(hydroximethyl)propane-1,3-diol, (H4L), and Mn(NO3)2.4H2O. The coordination reaction was promoted by the deprotonation of the ligand by the soft base triethylamine. The paper’s main contribution is the integration of the experimental and computational studies to explain the interesting magnetic behavior that the mixed valence manganese multimetallic core shows. The results presented herein, which are rarely found for Mn(II), (III) and (IV) complexes, will contribute to the understanding of the magnetic communication generated by the valence electrons and its repercussion in the local geometry and in the overall crystalline structure.

Bleispezies PbX und PbX2 als Brückenliganden in übergangsmetallorganisch geschützten Koordinationsverbindungen/ Leadspecies PbX and PbX2 as Bridging Ligands in Organometallic Protected Coordination Compounds

2002 ◽  
Vol 57 (1) ◽  
pp. 25-42 ◽  
Author(s):  
Peter Rutsch ◽  
Gottfried Huttner
Keyword(s):  
Coordination Compounds ◽  
Dynamic Behaviour ◽  
Disodium Salt ◽  
3D Nmr ◽  
Spectroscopic Techniques ◽  
The Novel ◽  
Bridging Ligands ◽  
X Ray ◽  
Nmr Data ◽  
First Time

The disodium salt Na2[{(CO)5Cr}2Pb(NO3)2], Na2·1, which contains a lead center in a (4+2) coordination mode, reacts with tetraphenylphosphonium halides [Ph4P]X to give the tetrahedral compounds [Ph4P]2[{(CO)5Cr}2PbX2] (X = Cl: 2a; X = Br: 2b; X = I: 2c). Substitution of the nitrate groups of Na2·1 by alcoxides leads to binuclear compounds of the type [{(CO)5Crg2Pb(μ2-OR)2Pb{Cr(CO)5}2]2- (R = Et: 3a; R = n -Pr: 3b; R = i-Pr: 3c; R = Allyl: 3d). NMR experiments show that these dimeric compounds are in equilibrium with the monomeric species [{(CO)5Cr}2PbR]- .Trialkylphosphanes react with Na2·1 to give the neutral phosphane complexes [{(CO)5Cr}2Pb(PR3)2] (R=Me: 4a; R=Et: 4b; R = n-Bu: 4c), which show dynamic behaviour in solution. All of the novel compounds have been characterized by X-ray analysis, as well as by the usual analytic and spectroscopic techniques. 207Pb-NMR data of Cr(CO)5- bound lead species are reported for the first time.

Vibrational Spectroscopic Characterization and Coherent Anti-Stokes Raman Spectroscopy (CARS) Imaging of Artepillin C

2020 ◽  
Vol 74 (7) ◽  
pp. 751-757
Author(s):  
Wallance M. Pazin ◽  
Leonardo N. Furini ◽  
Vita Solovyeva ◽  
Tibebe Lemma ◽  
Rafael J. G. Rubira ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Biological Systems ◽  
Spectroscopic Characterization ◽  
Spectroscopic Techniques ◽  
Spectroscopic Characteristics ◽  
Cars Microscopy ◽  
Surface Enhanced Raman ◽  
Artepillin C ◽  
Interesting Compound ◽  
Anti Stokes

In the following work, the vibrational spectroscopic characteristics of artepillin C are reported by means of Fourier transform infrared (FT-IR) and Raman spectroscopies, surface-enhanced Raman scattering (SERS), and coherent anti-Stokes Raman scattering (CARS) microscopy. Artepillin C is an interesting compound due to its pharmacological properties, including antitumor activity. It is found as the major component of Brazilian green propolis, a resinous mixture produced by bees to protect their hives against intruders. Vibrational spectroscopic techniques have shown a strong peak at 1599 cm−1, assigned to C=C stretching vibrations from the aromatic ring of artepillin C. From these data, direct visualization of artepillin C could be assessed by means of CARS microscopy, showing differences in the film hydration obtained for its neutral and deprotonated states. Raman-based methods show potential to visualize the uptake and action of artepillin C in biological systems, triggering its interaction with biological systems that are needed to understand its mechanism of action.

scholarly journals Synthesis and biological Evaluation of Some Abbreviated New Triazolopyrimidines

2019 ◽  
pp. 354-361
Author(s):  
Jatin Vora ◽  
Kartik Vyas
Keyword(s):  
Biginelli Reaction ◽  
Biological Evaluation ◽  
Spectroscopic Techniques ◽  
The Novel ◽  
Antibacterial And Antifungal Activity ◽  
1H Nuclear Magnetic Resonance ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal ◽  
Synthesis And Biological Evaluation ◽  
Compound Series

A cogent synthesis of completely new compound series of by 6-(3,5-bis(trifluoromethyl)phenyl)-4-(4-chlorophenyl)-3,4-dihydro pyrimidine-2(1H)-one (Biginelli reaction) was achieved by continue heating of (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(substituted phenyl)prop-2-en-1-one and urea for 5 hours with 40% KOH and ethyl alcohol. (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(substituted phenyl)prop-2-en-1-one is produced by Claisen-Schmidt Condensation. In this condensation 1-(3,5-bis(trifluoromethyl)phenyl)ethanone and different aldehyde are mixed. All the novel compound series were characterized by infrared and 1H nuclear magnetic resonance and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity

scholarly journals Narrative Structure and the Unnarrated in Colson Whitehead’s The Underground Railroad

2020 ◽  
pp. 11-33
Author(s):  
Paula Martin-Salvan
Keyword(s):  
Slave Narratives ◽  
Narrative Structure ◽  
Slave Narrative ◽  
Underground Railroad ◽  
The Novel ◽  
Working Hypothesis ◽  
Narrative Convention ◽  
Narrative Conventions

This paper analyzes the narrative structure of Colson Whitehead’s The Underground Railroad against the grain of traditional slave narrative conventions. The novel may be categorized as a neoslave narrative, telling the story of a slave girl, Cora, and her escape from a Georgia plantation using the “Underground Railroad” mentioned in the title. My working hypothesis takes cue from the explicit, literal rendering of the Underground Railroad in the text, which may be considered as symptomatic of Whitehead’s approach to the slave narrative convention, in that his novel discloses or makes visible aspects which, in slave narratives, were left unnarrated.

Characterization of fine particulate matter in ambient air by combining TEM and multiple spectroscopic techniques – NMR, FTIR and Raman spectroscopy

2015 ◽  
Vol 17 (3) ◽  
pp. 552-560 ◽  
Author(s):  
Zhurun Ji ◽  
Rucheng Dai ◽  
Zengming Zhang
Keyword(s):  
Raman Spectroscopy ◽  
Fine Particulate Matter ◽  
Ambient Air ◽  
Spectroscopic Techniques ◽  
Fine Particulate ◽  
Transmission Electron ◽  
Spectroscopic Characteristics ◽  
Infrared And Raman Spectroscopy ◽  
Ftir And Raman Spectroscopy

We report a study of the microstructures and spectroscopic characteristics of PM2.5and its potential sources in Beijing by combining transmission electron microscopy and multiple spectroscopic techniques: nuclear magnetic resonance, Fourier transform infrared and Raman spectroscopy.

Isoflavonoids from Bolusanthus speciosus (Bolus) Harms Leguminosae

1985 ◽  
Vol 40 (9-10) ◽  
pp. 617-620 ◽  
Author(s):  
Kaleab Asres ◽  
Paolo Mascagni ◽  
Melanie J. O’Neill ◽  
David Phillipson
Keyword(s):  
Biochanin A ◽  
Spectroscopic Techniques ◽  
The Novel ◽  
H Nmr

Abstract Seven isoflavonoids have been isolated from the seeds of Bolusanthus speciosus (Bolus) Harms. Five of these com pounds were identified as the isoflavones genistein (1), biochanin A (2), orobol (3), pratensein (4) and 3′-O-methylorobol (5). The remaining two compounds were characterised as the novel isoflavone 3′-O-methylpratensein (6) and the new 3-hydroxyisoflavanone bolusanthin (7). Identification and characterisation was by means of spectroscopic techniques (UV, IR, MS and 1H NMR). NOe irradiation of the C-2 proton of 3′-O-methylpratensein (6) was used to establish unequivocally the oxygenation pattern of the B-ring.

Synthesis and Characterization of Novel Re(BIAN)(CO)3Cl Derivatives Including the First Example of a Water-soluble Tricarbonyl Rhenium(I) Complex with Bis(imino)acenaphthene Ligands

2014 ◽  
Vol 69 (6) ◽  
pp. 691-698 ◽  
Author(s):  
Elham Kianfar ◽  
Uwe Monkowius ◽  
Engelbert Portenkirchner ◽  
Günther Knör
Keyword(s):  
Water Soluble ◽  
Spectroscopic Techniques ◽  
Ortho Position ◽  
The Novel ◽  
Carbonyl Derivative ◽  
Chloride Complexes ◽  
Carbonyl Chloride ◽  
Rhenium Carbonyl ◽  
Halide Ligand

A series of rhenium(I) carbonyl chloride complexes carrying bis(imino)acenaphthene (BIAN) molecules as p-acceptor ligands was prepared and characterized by various spectroscopic techniques. Among the novel compounds described, the remarkable example of a deeply colored water-soluble rhenium carbonyl derivative is presented. The crystal structures of this family of BIAN compounds are also reported, which confirm the position of the chloro ligand at the tricarbonyl rhenium(I) center. In the case of BIAN ligands carrying bulky substituents in the ortho-position of the arylimino subunits, evidence has been found for an exchange of the halide ligand in solution, which is considered to be of major relevance for catalytic applications. Implications of our results for the fields of photocatalytic CO2 reduction and the controlled release of the gasotransmitter CO in aqueous solution are briefly discussed.

scholarly journals Synthesis, Characterization and Magnetic Susceptibility of Novel Transition Metal Ion Complexes with (E)-2-((7H-Purin-6-ylimino)methyl)phenol and Its Antibacterial Efficiency

2021 ◽  
Vol 7 (4) ◽  
pp. 748-750
Author(s):  
S. Tihile Mangesh ◽  
N. Chaudhari Gajanan
Keyword(s):  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Transition Metal ◽  
Metal Ion ◽  
Spectroscopic Techniques ◽  
The Novel ◽  
Metal Ion Complexes ◽  
Transition Metal Ion ◽  
Ft Ir

The novel transition metal ion complexes were synthesized by refluxing the ethanolic solutions of metal acetates with Schiff base in 1:2 ratios. The structure and characterization of synthesized complexes of Mn (II), Co (II), Ni (II), Cu (II) and Zn (II) with Schiff base (E)-2-((7H-purin-6-ylimino)methyl)phenol were elucidated by using 1H NMR, FT-IR and UV-Visible spectroscopic techniques. The synthesized compounds were also been screened against gram positive and gram-negative bacteria. The novel compounds were further carried out for the study of magnetic susceptibility.

Interaction of spermine derivative porphyrin with DNA

2018 ◽  
Vol 22 (07) ◽  
pp. 581-587 ◽  
Author(s):  
Chiara M. A. Gangemi ◽  
Bruno D’Agostino ◽  
Rosalba Randazzo ◽  
Massimiliano Gaeta ◽  
Maria E. Fragalà ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Scientific Community ◽  
Covalent Binding ◽  
Resonance Light Scattering ◽  
Spectroscopic Techniques ◽  
Binding Modes ◽  
Ability To Act ◽  
Spectroscopic Characteristics ◽  
Degradation Activity ◽  
Ct Dna

Porphyrinoids are ideal compounds to be incorporated into DNA due to their peculiar spectroscopic characteristics, fascinating photochemistry and synthetic versatility. The ability to act as photosensitizers in the presence of oxygen promoted interest of the scientific community to study the non-covalent binding of porphyrins with DNA in order to use them in photodynamic therapy. Thus, the understanding of the mechanisms involved in the binding of porphyrins with DNA can help to find a porphyrin with specific base degradation activity. In this work we characterized the binding modes of spermine derivative porphyrin with three different polynucleotides: ct-DNA, poly(dG-dC)[Formula: see text] in both B- and Z-conformation using several spectroscopic techniques (UV-vis, Electronic Circular Dichroism and Resonance Light Scattering).

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