Asymmetric syntheses of optically active α-amino acids by hydrocyanic acid addition to the optically active Schiff base

1970 ◽  
Vol 48 (12) ◽  
pp. 1881-1884 ◽  
Author(s):  
Mahendra S. Patel ◽  
Michael Worsley
Keyword(s):  
Amino Acids ◽  
Schiff Base ◽  
Optical Purity ◽  
Optically Active ◽  
Hydrocyanic Acid ◽  
Asymmetric Syntheses ◽  
Acid Addition

The syntheses of L(+) and D(−) enantiomers of α-amino acids, norvaline, norleucine, and leucine, as their hydrochloride salts have been achieved in almost 100% optical purity and 40–60% overall yield.

scholarly journals Synthesis of Organic Molecules, R Ribose and S Amino Acids by Adsorption on Carbon at The Birth of Life on The Earth

2016 ◽  
Vol 12 (30) ◽  
pp. 1
Author(s):  
Vladimir Zhmakin
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Phosphoric Acid ◽  
Organic Molecules ◽  
Optical Purity ◽  
Optically Active ◽  
Volcanic Gas ◽  
Early Atmosphere ◽  
The Earth

Reasons for appearance of optically active organic molecules in nature have not been ascertained up to the present, but clarification of conditions on the Earth during the period of their appearance can contribute to this. H2 and gases, containing H2, were oxidized by CO2 with allocation of carbon and H2O or CH2O and СНO(OН) in volcanic gas and in the early atmosphere. During adsorption on carbon CH2O dissolved in water could be the synthesis only of R (rectus, Latin) ribose, and with NH3 and СНO(OН) synthesis of glycine and only of S (sinister) serine, and on its bases of other S amino acids. Adsorption on the carbon ensured in complex: concentration of initial components, hydrophobic-hydrophilic properties, optical purity, protection from hydration, decay and racemization. It is shown the possibility of the early Archean reactions: dehydration of phosphoric acid, of phosphoester bonds connection formation in nucleotides, with CH2O fatty acids and nitrogenous bases.

Asymmetric syntheses of optically active .alpha.,.beta.-disubstituted .beta.-amino acids

1993 ◽  
Vol 58 (17) ◽  
pp. 4758-4763 ◽  
Author(s):  
Kevin Burgess ◽  
Lee T. Liu ◽  
Biman Pal
Keyword(s):  
Amino Acids ◽  
Optically Active ◽  
Asymmetric Syntheses ◽  
Alpha Beta
Sign in / Sign up

Export Citation Format

Share Document