Effect of pH and phosphate ions on the polarographic behavior of D-glucuronolactone

1969 ◽  
Vol 47 (2) ◽  
pp. 265-272 ◽  
Author(s):  
R. J. Thibert ◽  
J. R. Johnston
Keyword(s):  
Aqueous Solution ◽  
Glucuronic Acid ◽  
Polarographic Determination ◽  
Polarographic Behavior ◽  
Effect Of Ph ◽  
Polarographic Wave ◽  
Phosphate Ions ◽  
Trialkyl Phosphites

The polarographic determination of D-glucuronolactone in aqueous solution was shown to be feasible up to a concentration of 6 mg per ml in KCl, NaCl, and LiCl with gelatin as the maximum suppressor. The effect of pH and phosphate ions on the polarographic wave of D-glucuronolactone is discussed and compared to the reaction of dialkyl hydrogen phosphites and trialkyl phosphites with β-propiolactones. The effect of pH and phosphate ions on the polarographic wave of D-glucuronic acid was also investigated.

THE POLAROGRAPHY OF THE MAGNESIUM-ALIZARIN SYSTEM

1963 ◽  
Vol 41 (7) ◽  
pp. 1695-1702 ◽  
Author(s):  
D. G. Brewer ◽  
John A. Page
Keyword(s):  
Aqueous Solution ◽  
Diffusion Coefficient ◽  
Ammonium Chloride ◽  
Polarographic Determination ◽  
Reduction Wave ◽  
Soluble Complex ◽  
Reversible Process ◽  
Complex Species ◽  
Polarographic Wave

The polarography of alizarin alone, and alizarin in the presence of magnesium, has been studied in an ammonia–ammonium chloride electrolyte. Alizarin was found to give a reduction wave with E1/2 = −(0.14 + 0.059 pH) volts vs. S.C.E. and a polarographic diffusion coefficient D, equal to 1.20 × 10−6 cm2 sec−1 over a range of pH from 7.4 to 10.0 in aqueous solution at 25 °C. The slope of the wave corresponded to a two-electron reversible process. The addition of magnesium caused a decrease in the polarographic wave for alizarin, but the combining ratio of magnesium to alizarin was a function of pH, ranging from 1.02 at pH 9.0 to 1.28 at pH 10.1. The combining ratio greater than unity could be attributed to alizarin adsorbed on a 1:1 (MgAlz) precipitate. The removal of alizarin from the solution was not quantitative in the presence of excess magnesium, and there is evidence of the formation of soluble complex species. The reaction is potentially useful for the indirect polarographic determination of magnesium.

Simultaneous Polarographic Determination of p-Nitro-2-acetamido-3-hydroxypropiophenone and 1-p-Nitrophenyl-2-amino-1,3-propanediol

1971 ◽  
Vol 54 (4) ◽  
pp. 884-892
Author(s):  
D Dumanović ◽  
J Volke ◽  
R Jovanović
Keyword(s):  
Polarographic Determination ◽  
Polarographic Behavior ◽  
Ph Range

Abstract The reduction of p-nitro-2-acetamido-3-hydroxypropiophenone is one of the steps in the synthesis of chloramphenicol by the Parke-Davis process. A simultaneous polarographic determination of the 2 compounds in the reaction mixture after the reduction of p-nitro-2-acetamido-3-hydroxypropiophenone has been proposed. The determination can be carried out in Britton-Robinson universal buffers over the pH range from 2 to 10. The polarographic behavior of the 3 compounds is described.

Polarographic Determination of Antihistamines by Complexation with Cd(II)

1986 ◽  
Vol 69 (2) ◽  
pp. 192-195 ◽  
Author(s):  
Aytekin Temizer ◽  
Nuran Özaltin
Keyword(s):  
Differential Pulse ◽  
Peak Height ◽  
Linear Range ◽  
Borate Buffer ◽  
Ammonium Salts ◽  
Polarographic Determination ◽  
Polarographic Behavior ◽  
Diphenhydramine Hydrochloride ◽  
Method Of Determination

Abstract The polarographic behavior of the complexes formed by Cd(II) ion with ethanolamine derivative antihistamines such as diphenhydramine hydrochloride, dimenhydrinate, and chlorphenoxamine hydrochloride was studied. Antihistamines form spontaneous complexes with Cd(II) ion in the presence of KNO3. In addition, pH 8.00 borate buffer was added to increase the differential pulse polarogram peak height, and tetraalkyl ammonium salts were added to increase the linear range. The method of determination developed has been applied to commercial tablet, capsule, elixir, and injection forms of ethanolamine derivative drugs and has been compared with official methods.

Anodic Polarographic Determination of Acetylenic Hypnotics Ethinamate and Methylpentynol Carbamate in Dosage Forms

1991 ◽  
Vol 74 (4) ◽  
pp. 592-595
Author(s):  
F Belal
Keyword(s):  
Sodium Hydroxide ◽  
Supporting Electrolyte ◽  
Electrode Reaction ◽  
Dosage Forms ◽  
Limiting Current ◽  
Polarographic Determination ◽  
Polarographic Behavior ◽  
The Waves

Abstract The polarographic behavior of ethinamate and methylpentynol carbamate was studied. Both drugs developed anodic waves in a supporting electrolyte composed of 1M sodium hydroxide and methanol (9 + 1). The relation between the limiting current and the concentration was rectilinear over the range 2.5 X 10-5-2.5 X 10-4M for both drugs. The characteristics of the waves were studied, and a model of the electrode reaction was suggested. The proposed method was successfully applied to the determination of the 2 drugs in their dosage forms, and the results were in agreement with those obtained with published methods.

Polarographic Determination of Organomercury Drugs

1965 ◽  
Vol 48 (3) ◽  
pp. 585-590
Author(s):  
Ted M Hopes
Keyword(s):  
Thin Layer ◽  
Linear Relationship ◽  
Therapeutic Efficacy ◽  
Total Mercury ◽  
Polarographic Determination ◽  
Reduction Peak ◽  
Polarographic Behavior ◽  
Peak Current ◽  
Layer Chromatography

Abstract Official NF, USP, and AOAC methods for organomercury drugs are long and determine only total mercury. Initial studies were made of the polarographic behavior of merbromin NF, on a Polarotrace Model K-1000. The peak current of a reduction peak that was found to be specific for the carbon-mercury bond was not directly proportional to concentration in pH 7.5 Britton-Robinson buffer-KCl solution. A much stronger peak, derived from another group in the molecule, exhibited a linear relationship between peak current and concentration in the 10–100 μg/ml range. Column and thin-layer chromatography of commercial merbromin indicates the presence of a number of compounds. Further work on the polarographic determination of merbromin will require the preparation of an adequate standard and a judgment of the therapeutic efficacy of the compounds present in merbromin preparations.

Sign in / Sign up

Export Citation Format

Share Document