Chemical and biological properties of some oxindolidyl-3-methines

1968 ◽  
Vol 46 (13) ◽  
pp. 2189-2194 ◽  
Author(s):  
R. Hodges ◽  
J. S. Shannon ◽  
W. D. Jamieson ◽  
A. Taylor
Keyword(s):  
Bacillus Subtilis ◽  
Absorption Band ◽  
Carbonyl Group ◽  
Mass Spectrometer ◽  
Wittig Reaction ◽  
Biological Properties ◽  
Residual Fragment ◽  
Nitrofuran Derivatives

Several 1-methyloxindohdyl-3-methines have been synthesized, either by condensation of 1-methyloxindole with an aldehyde, or by a Wittig reaction of a chloromethylene compound with a 1-methylisatin When examined m the mass spectrometer the expected ion reactions were observed and, in addition, a reaction involving expulsion of the carbonyl group of the oxindole moiety and rearrangement of the residual fragment, to give a 1-methylbenzo[b]azepinium ion was observed. The anions of the oxindolidyluracilmethines 4 and 5, (R = Me, R′ = OH) had an absorption band near 380 mμ but the corresponding neutral molecules absorbed at 325–350 mμ. The 5-nitrofuran derivatives 3 were the only compounds that inhibited the growth of Bacillus subtilis.

scholarly journals Intramolecular Aza-Wittig Reaction of Iminophosphoranes with the b-Lactam Carbonyl Group

1997 ◽  
Author(s):  
Mateo Alajarín ◽  
Pedro Molina ◽  
Angel Vidai ◽  
Fulgencio Tovar
Keyword(s):  
Carbonyl Group ◽  
Wittig Reaction ◽  
Lactam Carbonyl Group ◽  
Lactam Carbonyl

On the synthesis and biological properties of isocombretastatins: a case of ketone homologation during Wittig reaction attempts

RSC Advances ◽  
2013 ◽  
Vol 3 (11) ◽  
pp. 3683 ◽  
Author(s):  
Vivien Stocker ◽  
Alina Ghinet ◽  
Marie Leman ◽  
Benoît Rigo ◽  
Régis Millet ◽  
...  
Keyword(s):  
Wittig Reaction ◽  
Biological Properties

THE BIOLOGICAL PROPERTIES OF 3,6-EPIDITHIADIKETO-PIPERAZINES. DEGRADATION OF GLIOTOXIN-B BY BACILLUS SUBTIL IS (HLX 373)

1967 ◽  
Vol 13 (12) ◽  
pp. 1577-1589 ◽  
Author(s):  
D. Brewer ◽  
A. Taylor
Keyword(s):  
Bacillus Subtilis ◽  
Biological Properties ◽  
Chemical Degradation ◽  
Available Nitrogen ◽  
Disulfide Group ◽  
Number Of Cells

Like sporidesmin, gliotoxin catalyzes the decomposition of azide in the presence of iodine, and this catalysis can be used for its estimation. The presence of respiring cells of Bacillus subtilis does not interfere with the estimation. Thus it was possible to show that the concentration of gliotoxin decreased when solutions of the antibiotic were incubated with respiring cells. The rate of the decomposition was independent of the gliotoxin concentration in the range 2–25 μg/ml, but was dependent on the number of cells, the pH, and the available nitrogen in the suspending medium. Loss of gliotoxin was most rapid at pH 5.5 and continued when the supernatant was reincubated after centrifugal removal of the cells. No loss of gliotoxin occurred when solutions were incubated in the absence of cells at pH 5.5. By contrast, chemical degradation at pH 8.0 was inhibited in the presence of cells. These results are consistent with the hypothesis that B. subtilis secretes an enzyme which degrades the disulfide group in gliotoxin.

ChemInform Abstract: The First Aza-Wittig Reaction of the β-Lactam Carbonyl Group.

ChemInform ◽  
2010 ◽  
Vol 30 (8) ◽  
pp. no-no
Author(s):  
M. ALAJARIN ◽  
P. MOLINA ◽  
A. VIDAL ◽  
F. TOVAR
Keyword(s):  
Carbonyl Group ◽  
Wittig Reaction ◽  
Lactam Carbonyl Group ◽  
Lactam Carbonyl

scholarly journals CULTURAL MORPHOLOGICAL AND BIOCHEMICAL CHARACTERISTICS OF BACILLUS SUBTILIS STRAINS

2019 ◽  
pp. 58-62
Author(s):  
V. S. Rusaleyev ◽  
О. V. Pruntova ◽  
D. A. Vasilyev
Keyword(s):  
Bacillus Subtilis ◽  
Storage Period ◽  
Biological Properties ◽  
Antagonistic Activity ◽  
Antagonistic Effect ◽  
Lag Phase ◽  
Probiotic Properties ◽  
Biochemical Characteristics ◽  
Species Characteristics ◽  
One Year

A decrease in therapeutic effect of some live lacto- and bifdobacteria-based drugs for veterinary use has been observed for the last 20 years that urges scientists to search for new microorganisms possessing probiotic properties. Many studies in this feld are focused onBacillus subtilisthat is widespread in the environment and non-pathogenic for animals and humans. Results of tests ofBacillus subtilisfor its biological properties and antagonistic activity aimed at optimization of methodical approaches for detection of strain with the highest antagonistic effect on some opportunistic microorganisms and their further use as probiotics are described. Cultural morphological and biochemical characteristics of the tested strains conformed to the species characteristics ofBacillus subtilis.Tested strains were nonpathogenic for white mice. Tests showed that spore biomass could be prepared both in liquid and on solid nutrient media. Methodically, spore biomass preparation in liquid nutrient medium is preferable. The tests showed that spores emerged from anabiosis non-uniformly and it depended on original seed spore storage period. Spore cultures stored less than one year emerged from anabiosis more quickly. It was found that the spores formed more readily when the cultures were aerated with oxygen as well as that lag-phase culture medium had a stimulating effect onBacillus subtilisspore germination.Bacillus subtilisstrains were found to have antagonistic effect onEscherichia coli, SalmonellaandStaphylococcus. Area of growth inhibition of the said bacteria was 15–20 mm. TestedBacillus subtilisstrains could be proposed for use as probiotics.

Sign in / Sign up

Export Citation Format

Share Document