A study of cis-trans isomerism and conformational preferences of thioanilides

1967 ◽  
Vol 45 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Ian D. Rae
Keyword(s):  
Hydrogen Bonding ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Isomer Ratio ◽  
Ring Plane ◽  
Thioamide Group ◽  
Conformational Preferences ◽  
Ortho Substituent ◽  
Do So

In thioanilides, cis-trans isomerism has been clearly differentiated from thioamide – thiolimidic acid tautomerism. The isomer ratio has been related to structural and environmental influences on the thioamide group by means of infrared and proton magnetic resonance spectroscopy. In the thioanilides, the thioamide group does not lie in the ring plane unless constrained to do so by hydrogen bonding between the thioamide proton and a suitable ortho substituent.

Solvent effects on the conformations of ortho-nitroanilines

1967 ◽  
Vol 20 (6) ◽  
pp. 1173 ◽  
Author(s):  
ID Rae
Keyword(s):  
Nitro Group ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Aromatic Proton ◽  
Intramolecular Hydrogen Bonding ◽  
Resonance Spectroscopy ◽  
Ring Plane ◽  
Polar Solvents ◽  
Resonance Position ◽  
Intramolecular Hydrogen

Proton magnetic resonance spectroscopy has been used to examine the conformations of a number of ortho-nitroanilines in solution. In solvents of low polarity, intramolecular hydrogen bonding maintains the coplanarity of the nitro group and the aromatic ring, but in more polar solvents the nitro group is rotated from the ring plane and this change is evidenced by an upfield shift in the resonance position of the adjacent aromatic proton. The extent of rotation depends on the polarity of the solvent and on the structure of the amine.

Librations Around the C(S)—Phenyl Bond in N-Thiobenzoylmorpholines Observed by 220 MHz Proton Magnetic Resonance Spectroscopy

1975 ◽  
Vol 53 (21) ◽  
pp. 3315-3318 ◽  
Author(s):  
Adrian O. Fulea ◽  
Peter J. Krueger
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Spectral Data ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Thioamide Group ◽  
Related Compounds

The 220 MHz p.m.r. spectra of 4-(4′-nitrothiobenzoyl)-2,6-dimethylmorpholine (1) provide evidence for the progressive freezing of the librations of the thioamide group around the C(S)—Ph bond as the temperature is lowered. This is supported by spectral data on related compounds in which the aromatic and hetero-ring substituents are altered.

scholarly journals Imaging intelligence with proton magnetic resonance spectroscopy

Intelligence ◽  
2009 ◽  
Vol 37 (2) ◽  
pp. 192-198 ◽  
Author(s):  
Rex E. Jung ◽  
Charles Gasparovic ◽  
Robert S. Chavez ◽  
Arvind Caprihan ◽  
Ranee Barrow ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy

Disulfiram Determination by Proton Magnetic Resonance Spectroscopy and by Colorimetry

1973 ◽  
Vol 56 (1) ◽  
pp. 124-127 ◽  
Author(s):  
Eric B Sheinin ◽  
Walter R Benson ◽  
Myron M Smith
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Colorimetric Method ◽  
Drug Substance ◽  
Resonance Spectroscopy ◽  
Pmr Spectroscopy ◽  
Label Claim ◽  
Tablet Excipients

Abstract Disulfiram was determined in disulfiram drug substance and tablets by proton magnetic resonance (PMR) spectroscopy at the 100–480 mg level and by a colorimetric technique involving cuprous iodide at the 50 mg level. The tablet excipients do not interfere in the analysis. The average result for disulfiram in a tablet composite was 100.8±1.4% of label claim by PMR and 100.7±0.4% by the colorimetric method.

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