DETERMINATION OF α OR β SUBSTITUTION OF THE INDOLE NUCLEUS BY NUCLEAR MAGNETIC RESONANCE

1963 ◽  
Vol 41 (8) ◽  
pp. 2067-2073 ◽  
Author(s):  
R. V. Jardine ◽  
R. K. Brown
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Chemical Shift ◽  
Solvent Effect ◽  
Polar Solvents ◽  
Nuclear Magnetic

Marked differences in chemical shift of the signal for the α proton in indole and substituted indoles occur when spectra are obtained in non-polar and polar solvents. In contrast, using polar and non-polar solvents, only small differences are observed in the chemical shift of the signal for the β proton in indoles. The utility of the solvent effect on the chemical shift to distinguish between α and β substitution of the indole nucleus is pointed out.

Determination of for aliphatic ketones from nuclear magnetic resonance chemical shift data

1970 ◽  
Vol 48 (12) ◽  
pp. 1919-1923 ◽  
Author(s):  
Donald G. Lee
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Raman Spectroscopy ◽  
Magnetic Resonance ◽  
Chemical Shift ◽  
Aliphatic Ketones ◽  
Chemical Shift Data ◽  
Shift Data ◽  
Good Agreement ◽  
Nuclear Magnetic

The [Formula: see text] values for 3-pentanone, 2-butanone, and 3-methyl-2-butanone have been determined from chemical shift data. The values (−7.6, −7.1, and −7.2, respectively) are in good agreement with those previously determined for aliphatic ketones by use of ultraviolet–visible and Raman spectroscopy.

THE CHEMICAL SHIFT OF AROMATIC ALKOXY GROUPS

1962 ◽  
Vol 40 (9) ◽  
pp. 1865-1869 ◽  
Author(s):  
Clayton Heathcock
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Chemical Shift ◽  
Solvent Effect ◽  
Chemical Shifts ◽  
Alkoxy Groups ◽  
Nuclear Magnetic

The nuclear magnetic resonance (n.m.r.) spectra of 42 variously substituted anisoles and phenetoles have been obtained. The chemical shifts of the alkoxy hydrogens have been assembled in charts for ready use in interpreting the n.m.r. spectra of unknown compounds. For meta- and para-substituted anisoles, a reasonably good correlation has been shown to exist between the methyl resonance and the corresponding Hammett σ parameter. With anisole itself, a preferential solvent effect has been noticed which suggests a specific type of interaction between solute molecules.

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