PROTON MAGNETIC RESONANCE SPECTROSCOPY AND THE SULPHATION OF LINEAR AND BRANCHED DEXTRAN

1963 ◽  
Vol 41 (3) ◽  
pp. 777-782 ◽  
Author(s):  
W. M. Pasika ◽  
L. H. Cragg
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectrum ◽  
Chain Scission ◽  
Proton Magnetic Resonance Spectrum ◽  
Resonance Spectroscopy ◽  
Peak Areas ◽  
Magnetic Resonance Spectra

The introduction of sulphate groups into dextran produces characteristic changes in its proton magnetic resonance spectrum. With linear dextran a new signal appears which can be attributed solely to an effect of sulphate groups; with branched dextran this signal coincides with that due to the branching. From a comparison of peak areas in these spectra with peak areas in the spectra of the unsulphated linear and branched dextrans it is concluded that during sulphation no appreciable degradation occurred, whether by chain scission or branch hydrolysis.The proton magnetic resonance spectra also provide evidence for preferential substitution of sulphate at carbon 2 in the anhydroglucose unit.

scholarly journals THE DETECTION AND ESTIMATION OF BRANCHING IN DEXTRAN BY PROTON MAGNETIC RESONANCE SPECTROSCOPY

1963 ◽  
Vol 41 (2) ◽  
pp. 293-299 ◽  
Author(s):  
W. M. Pasika ◽  
L. H. Cragg
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectrum ◽  
Quantitative Measure ◽  
Proton Magnetic Resonance Spectrum ◽  
Resonance Spectroscopy ◽  
Branch Points ◽  
Detection And Estimation

The proton magnetic resonance spectrum of branched dextran contains a peak, not found in the spectrum of linear dextran, which is assigned to C1 protons at non-1,6-linkages—linkages which in most branched dextrans form the branch points. A quantitative measure of the extent of branching—the ratio of 1,6-linkages to non-1,6-linkages—is obtained by taking the ratio of the areas of the peaks associated with these two types of linkages. The value so obtained agrees well with that obtained by periodate analysis.For polysaccharides in which the non-1,6-linkages are known to be at branch points, n.m.r. spectroscopy thus affords a means of detecting and estimating branching which is more convenient than methods currently in use.

scholarly journals Imaging intelligence with proton magnetic resonance spectroscopy

Intelligence ◽  
2009 ◽  
Vol 37 (2) ◽  
pp. 192-198 ◽  
Author(s):  
Rex E. Jung ◽  
Charles Gasparovic ◽  
Robert S. Chavez ◽  
Arvind Caprihan ◽  
Ranee Barrow ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy

Disulfiram Determination by Proton Magnetic Resonance Spectroscopy and by Colorimetry

1973 ◽  
Vol 56 (1) ◽  
pp. 124-127 ◽  
Author(s):  
Eric B Sheinin ◽  
Walter R Benson ◽  
Myron M Smith
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Colorimetric Method ◽  
Drug Substance ◽  
Resonance Spectroscopy ◽  
Pmr Spectroscopy ◽  
Label Claim ◽  
Tablet Excipients

Abstract Disulfiram was determined in disulfiram drug substance and tablets by proton magnetic resonance (PMR) spectroscopy at the 100–480 mg level and by a colorimetric technique involving cuprous iodide at the 50 mg level. The tablet excipients do not interfere in the analysis. The average result for disulfiram in a tablet composite was 100.8±1.4% of label claim by PMR and 100.7±0.4% by the colorimetric method.

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