NITROGEN-FREE DERIVATIVES OF ATISINE: AN EXTREMELY HINDERED CARBOXYLIC ACID

1962 ◽  
Vol 40 (4) ◽  
pp. 630-643 ◽  
Author(s):  
J. W. ApSimon ◽  
O. E. Edwards ◽  
R. Howe
Keyword(s):  
Carboxylic Acid ◽  
Internal Oxidation ◽  
Nitrous Acid ◽  
Good Yield ◽  
Transformation Products ◽  
Diterpenoid Alkaloids ◽  
Reduction Reactions ◽  
Oxidation Reduction ◽  
Derivatives Of

The action of nitrous acid on azomethines derived from the alkaloid atisine gave a good yield of nitrogen-free hemiacetal, thus providing the first means of removing the nitrogen from the diterpenoid alkaloids. Transformation products of the hemiacetal, including the most hindered carboxylic acid hitherto known, are described. The internal oxidation–reduction reactions encountered in this and related work are discussed.

Oxidation - Reduction Reactions of Tetrachloroaurate(III) Anion with Triphenyl Derivatives of Group V Elements

1973 ◽  
Vol 56 (7) ◽  
pp. 2405-2418 ◽  
Author(s):  
Raymond Roulet ◽  
Nguyen Quang Lan ◽  
W. Roy Mason ◽  
Gerald P. Fenske
Keyword(s):  
Group V ◽  
Reduction Reactions ◽  
Oxidation Reduction ◽  
Derivatives Of

Derivate des Benzo[1.3]dioxols, 431 Über Benzo [1.3] dioxolcarbonsäuren / Derivatives of 1,3-Benzodioxoles, 43 1,3-Benzodioxolecarboxylic Acids

1978 ◽  
Vol 33 (7-8) ◽  
pp. 465-471
Author(s):  
Franz Daliacker ◽  
Volker Mues ◽  
In-O Kim
Keyword(s):  
Carboxylic Acid ◽  
Methyl Ester ◽  
Benzoic Acid ◽  
Myristic Acid ◽  
Good Yield ◽  
Acid Ester ◽  
Acid Methyl Ester ◽  
Acid Methyl ◽  
Derivatives Of

Abstract We describe the possibilities of formation and preparation of the “natural” 1,3-benzodioxolecarboxylic acids 1, 2, 4, 6 b, and 7, already mentioned in literature. Myristic acid (3e) was prepared in good yield from 3-methoxy-4,5-dihydroxy-benzoic acid ester (3c) , which could be easily made from 3-methoxy-2,3-carbonyldioxy-benzoic acid methylester (3b). Myristicic acid methylester (3d) could be subjected to methylation and hydrolysis leading to 3e without any difficulties. 4.6-dimethoxy-1,3-benzodioxole-5-carboxylic acid (5b) was prepared in good yields by oxidation of 4,6-dimethoxy-1,3-benzodioxole-5-aldehyde (5a). 5.7-dimethoxy-1,3-benzodioxole-carboxylic acid (13f), one of the “unnatural” 1,3-benzodioxolecarboxylic acids, derivatives of o-ipiperonylic acid (8), was prepared from 5-amino-7-methoxy-1,3- benzodioxole-4carboxylic acid methyl ester (13b) by diazotisation, elimination of nitrogen, methylation, and hydrolysis. A comparison of our measured pkA-values showed the strongest acidity belonging to 5,6-dimethoxy-1,3-benzodioxole-4-carbocylic acid (11).

ChemInform Abstract: OXIDATION - REDUCTION REACTIONS OF TETRACHLOROAURATE(III) ANION WITH TRIPHENYL DERIVATIVES OF GROUP V ELEMENTS

1974 ◽  
Vol 5 (5) ◽  
pp. no-no
Author(s):  
RAYMOND ROULET ◽  
NGUYEN QUANG LAN ◽  
W. ROY MASON ◽  
GERALD P. JUN. FENSKE
Keyword(s):  
Group V ◽  
Reduction Reactions ◽  
Oxidation Reduction ◽  
Derivatives Of

Stereochemical studies. VI. Stereoselective synthesis of trans-fused octahydroindene-1-carboxylic acids

1980 ◽  
Vol 33 (1) ◽  
pp. 101 ◽  
Author(s):  
M Galteri ◽  
PH Lewis ◽  
S Middleton ◽  
LE Stock
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Good Yield ◽  
Stereoselective Synthesis ◽  
Carboxyl Group ◽  
Derivatives Of ◽  
Acyl Derivatives

The trans-fused octahydroindene-1-carboxylic acid (9) having a pseudo- axial carboxyl group is formed in good yield on oxidation of 2-acyl derivatives of trans-fused octahydronaphthalen-1(2H)-one. On epimerization it yields the pseudo-equatorial isomer (3) which is structurally related to the gibberellic acids.

Feedback Controlled Chemical Reactor with Feed of Two Reaction Components with Spectrophotometric Indication

1994 ◽  
Vol 59 (3) ◽  
pp. 549-557
Author(s):  
František Skopal ◽  
Václav Dušek
Keyword(s):  
Sulfuric Acid ◽  
Negative Feedback ◽  
Chemical Reactor ◽  
Reduction Reactions ◽  
Oxidation Reduction

Theoretical relationships and simplifying conditions have been derived for the feed of two reaction components into a nonisochoric reactor with ideal stirring. The feed of reaction components is controlled by the negative feedback at a constant absorbance of the reaction mixture. The theoretical relationships have been verified using model 2. order oxidation-reduction reactions of Ce(IV)/V(IV) and Fe(III)/V(III) in 1 M sulfuric acid at 20 °C.

scholarly journals Novel Derivatives of 4-Methyl-1,2,3-Thiadiazole-5-Carboxylic Acid Hydrazide: Synthesis, Lipophilicity, and In Vitro Antimicrobial Activity Screening

2021 ◽  
Vol 11 (3) ◽  
pp. 1180
Author(s):  
Kinga Paruch ◽  
Łukasz Popiołek ◽  
Anna Biernasiuk ◽  
Anna Berecka-Rycerz ◽  
Anna Malm ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Carboxylic Acid ◽  
Bacterial Infections ◽  
Acid Hydrazide ◽  
Antimicrobial Effect ◽  
In Vitro Antimicrobial Activity ◽  
Research Goal ◽  
New Compounds ◽  
Derivatives Of

Bacterial infections, especially those caused by strains resistant to commonly used antibiotics and chemotherapeutics, are still a current threat to public health. Therefore, the search for new molecules with potential antimicrobial activity is an important research goal. In this article, we present the synthesis and evaluation of the in vitro antimicrobial activity of a series of 15 new derivatives of 4-methyl-1,2,3-thiadiazole-5-carboxylic acid. The potential antimicrobial effect of the new compounds was observed mainly against Gram-positive bacteria. Compound 15, with the 5-nitro-2-furoyl moiety, showed the highest bioactivity: minimum inhibitory concentration (MIC) = 1.95–15.62 µg/mL and minimum bactericidal concentration (MBC)/MIC = 1–4 µg/mL.

Volumetric studies in oxidation-reduction reactions

1958 ◽  
Vol 19 ◽  
pp. 10-11 ◽  
Author(s):  
Balwant Singh ◽  
Sardul Singh
Keyword(s):  
Reduction Reactions ◽  
Oxidation Reduction
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