SOME BASIC DERIVATIVES OF 6-CHLOROQUINAZOLINE AND PHTHALAZINE

1956 ◽  
Vol 34 (11) ◽  
pp. 1557-1561 ◽  
Author(s):  
Stanley O. Winthrop ◽  
Stella Sybulski ◽  
Roger Gaudry ◽  
Gordon A. Grant
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Physiological Action ◽  
The Central Nervous System ◽  
Derivatives Of ◽  
System Sodium

Basic derivatives of 6-chloroquinazoline and phthalazine have been synthesized and screened for their physiological action on the central nervous system. Sodium dialkylaminoalkoxides and the appropriate chlorobenzodiazine were brought together to yield basic ethers of 6-chloroquinazoline and phthalazine respectively. 1-(γ-Dimethylaminopropylamino)phthalazine was also prepared.

A comparison of some pharmacological effects of naloxone and N-methylnaloxone in mice

1982 ◽  
Vol 60 (5) ◽  
pp. 715-719 ◽  
Author(s):  
K. Ramabadran ◽  
C. Suaudeau ◽  
J. J. C. Jacob
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Subcutaneous Administration ◽  
Intracerebroventricular Injection ◽  
Pharmacological Effects ◽  
Opioid Antagonists ◽  
Hot Plate ◽  
Two Factors ◽  
The Central Nervous System ◽  
Derivatives Of

The effects of N-methylnaloxone following subcutaneous and intracerebroventricular administrations on nociception were investigated using the hot plate technique. Unlike naloxone, subcutaneous administration of N-methylnaloxone did not enhance the nociceptive reactions. In contrast, intracerebroventricular injection of N-methylnaloxone produced antinociception and tremor. Compared with naloxone, N-methylnaloxone was very weak in precipitating the signs of abstinence in mice rendered acutely dependent on morphine. Two factors, poor penetration into the central nervous system and steric hindrance, might render N-methylnaloxone very weak and hence both these factors must be taken into consideration while analyzing the effects following quaternary derivatives of opioid antagonists.

scholarly journals Isolation and partial characterization of methylated arginines from the encephalitogenic basic protein of myelin

1971 ◽  
Vol 123 (1) ◽  
pp. 69-74 ◽  
Author(s):  
G. S. Baldwin ◽  
P. R. Carnegie
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ion Exchange ◽  
Human Brain ◽  
Conformational Changes ◽  
Basic Protein ◽  
The Central Nervous System ◽  
Derivatives Of ◽  
Exchange Behaviour

Two methylated derivatives of arginine were isolated from the encephalitogenic protein of myelin from the central nervous system. Evidence is presented for the proposed structures, ω-NN′-dimethylarginine and ω-N-monomethylarginine. In the encephalitogenic protein from human brain the proportion 1:6:10 for arginine:monomethylarginine:dimethylarginine residues was found to occur at position 107. Possible roles for the methylated arginine in conformational changes and altered ion-exchange behaviour are discussed.

A Clinical Trial with a New Anticonvulsant Drug, α-(P-Aminophenyl)-α-Ethyl Glutarimide Preparation 16038 (Ciba)

1959 ◽  
Vol 105 (439) ◽  
pp. 448-456 ◽  
Author(s):  
Walter Fabisch
Keyword(s):  
Clinical Trial ◽  
Central Nervous System ◽  
Nervous System ◽  
Animal Experiments ◽  
Anticonvulsant Drug ◽  
The Central Nervous System ◽  
Derivatives Of

Derivatives of glutarimide are known to exert an effect upon the central nervous system. To name only two which are widely used for clinical purposes: Glutethimide (“Doriden”) is a sedative, Bemigride (“Megimide”) a stimulant. Preparation 16038 (Ciba) α-(p-aminophenyl)-α-ethyl glutarimide, in animal experiments had shown properties which suggested its use as an anticonvulsant, and this paper is an account of a clinical trial with the substance on in- and out-patients suffering from epilepsy.

The derivatives of theWnt3a lineage in the central nervous system

2007 ◽  
Vol 504 (5) ◽  
pp. 550-569 ◽  
Author(s):  
Angeliki Louvi ◽  
Michio Yoshida ◽  
Elizabeth A. Grove
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
The Central Nervous System ◽  
Derivatives Of

scholarly journals I. On the physiological action of β lutidine

1881 ◽  
Vol 32 (212-215) ◽  
pp. 162-170
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Physiological Action ◽  
The Central Nervous System ◽  
Brain And Spinal Cord ◽  
The Brain

In studying the physiological action of β lutidine the greater number of our experiments were made upon the frog, and more particularly related to the action of this substance upon the heart and central nervous system; our other experiments upon the different organs being for the better interpretation of the action upon these two. Heart . In all cases we first destroyed the brain and spinal cord of the frog by pithing, and with the smallest possible loss of blood. Hence none of the results obtained could be due to the central nervous system.

Sign in / Sign up

Export Citation Format

Share Document