Multi-component supramolecular synthesis of spirooxindoles catalyzed by β-cyclodextrin in water
2009 ◽
Vol 87
(12)
◽
pp. 1704-1707
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Keyword(s):
One Pot
◽
A neutral and efficient one-pot three-component aqueous-phase synthesis is developed for various spirooxindole derivatives from isatin, malononitrile, and 1,3-dicarbonyl compounds in high yields by supramolecular catalysis involving β-cyclodextrin. The β-cyclodextrin can be recovered and reused a number of times without any loss of activity.