Synthesis of β-amino alcohols using MgO as a new catalyst under solvent-free conditions

2008 ◽  
Vol 86 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Mona Hosseini-Sarvari
Keyword(s):  
Ring Opening ◽  
Amino Alcohols ◽  
Solvent Free ◽  
Aliphatic Amines ◽  
Solvent Free Conditions ◽  
Ring Opening Of Epoxides ◽  
High Yields ◽  
Aromatic And Aliphatic Amines

MgO catalyzed efficiently the ring opening of epoxides with a range of aromatic and aliphatic amines to produce β-substituted alcohols in high yields under solvent-free conditions. Exclusive trans stereoselectivity is observed for cyclic epoxide.Key words: MgO, β-amino alcohols, solvent-free, epoxide, amine.

scholarly journals Regioselective Ring Opening of Epoxides with Amines Using Silica-bonded S-sulfonic Acid under Solvent-free Conditions

2017 ◽  
Vol 56 (4) ◽  
Author(s):  
Mahmood Tajbakhsh ◽  
Rahman Hosseinzadeh ◽  
Parizad Rezaee ◽  
Heshmatollah Alinezhad
Keyword(s):  
Ring Opening ◽  
Sulfonic Acid ◽  
Room Temperature ◽  
Amino Alcohols ◽  
Solvent Free ◽  
High Yield ◽  
Reusable Catalyst ◽  
Solvent Free Conditions ◽  
Ring Opening Of Epoxides

Silica-bonded S-sulfonic acid (SBSSA) was used as a recyclable and reusable catalyst for the synthesis of β-amino alcohols. Several amines were reacted with epoxides to afford regioselective β-amino alcohols in high yield under solvent-free conditions at room temperature.

Uncatalysed Preparation of α-Amino Phosphonates under Solvent Free Conditions

2005 ◽  
Vol 2005 (5) ◽  
pp. 324-327 ◽  
Author(s):  
Mohamed Zahouily ◽  
Abdelhakim Elmakssoudi ◽  
Abdessamad Mezdar ◽  
Ahmed Rayadh ◽  
Saïd Sebti
Keyword(s):  
Microwave Irradiation ◽  
Carbonyl Compounds ◽  
Environmentally Friendly ◽  
Solvent Free ◽  
Aliphatic Amines ◽  
Solvent Free Conditions ◽  
Dialkyl Phosphites ◽  
High Yields ◽  
Amino Phosphonates ◽  
Aromatic And Aliphatic Amines

A simple, efficient and environmentally friendly procedure has been developed for the three component coupling of carbonyl compounds, aromatic and aliphatic amines and dialkyl phosphites to produce α-amino phosphonates. The α-amino phosphonates are synthesised in high yields (74–97%) in a few minutes (1–3 min) by microwave irradiation under solvent-free conditions, avoiding the use of any catalyst.

Sign in / Sign up

Export Citation Format

Share Document