Aqua-mediated one-pot synthesis and aromatization of pyrimido-fused 1,4-dihydropyridine derivatives using ammonium salts

2007 ◽  
Vol 85 (5) ◽  
pp. 400-405 ◽  
Author(s):  
Mazaahir Kidwai ◽  
Kavita Singhal
Keyword(s):  
Ammonium Nitrate ◽  
Single Step ◽  
Ammonium Salts ◽  
Environmentally Benign ◽  
High Yield ◽  
Pyridine Derivatives ◽  
One Pot ◽  
One Pot Synthesis ◽  
Synthetic Procedure ◽  
Dihydropyridine Derivatives

Dipyrimidine-fused pyridine derivatives were synthesized using 1,3-diketone, aldehyde, different ammonium salts, and water, as the solvent. Aromatization was observed when ammonium nitrate was used as the source of nitrogen, and thus, dipyrimidine-fused pyridine derivatives were synthesized in one-pot synthetic procedure. This environmentally benign procedure leads to high yield of products (80%–90%) in a single step, with greater purity using water as the solvent.Key words: water, aromatization, dipyrimidopyridine, ammonium salts.

Design, Synthesis, In vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-a]Pyridines as Potent Anti-Breast Cancer Agents

2019 ◽  
Vol 19 (2) ◽  
pp. 265-275 ◽  
Author(s):  
Faeze Khalili ◽  
Sara Akrami ◽  
Malihe Safavi ◽  
Maryam Mohammadi-Khanaposhtani ◽  
Mina Saeedi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
High Yield ◽  
Breast Cancer Cell Lines ◽  
Pyridine Derivatives ◽  
One Pot ◽  
Standard Drug ◽  
Three Component Reaction ◽  
Anti Cancer

Background: This paper reports synthesis, cytotoxic activity, and apoptosis inducing effect of a novel series of styrylimidazo[1,2-a]pyridine derivatives. Objective: In this study, anti-cancer activity of novel styrylimidazo[1,2-a]pyridines was evaluated. Methods: Styrylimidazo[1,2-a]pyridine derivatives 4a-o were synthesized through a one-pot three-component reaction of 2-aminopyridines, cinnamaldehydes, and isocyanides in high yield. All synthesized compounds 4a-o were evaluated against breast cancer cell lines including MDA-MB-231, MCF-7, and T-47D using MTT assay. Apoptosis was evaluated by acridine orange/ethidium bromide staining, cell cycle analysis, and TUNEL assay as the mechanism of cell death. Results: Most of the synthesized compounds exhibited more potent cytotoxicity than standard drug, etoposide. Induction of apoptosis by the most cytotoxic compounds 4f, 4g, 4j, 4n, and 4m was confirmed through mentioned methods. Conclusion: In conclusion, these results confirmed the potency of styrylimidazo[1,2-a]pyridines for further drug discovery developments in the field of anti-cancer agents.

One-pot synthesis of sulfones via Ni(II)-catalyzed sulfonylation of boronic acids, Na2S2O5 and benzylic ammonium salts

2021 ◽  
Vol 505 ◽  
pp. 111500
Author(s):  
Haibo Zhu ◽  
Yishuai Liu ◽  
Yingying Zhang ◽  
Liu Yang ◽  
Jia Meng ◽  
...  
Keyword(s):  
Boronic Acids ◽  
Ammonium Salts ◽  
One Pot ◽  
One Pot Synthesis

Catalytic application of SO42−/Fe–ZrO2nanoparticles synthesized by a urea hydrolysis method for environmentally benign one pot synthesis of 1,8-dioxodecahydroacridines

RSC Advances ◽  
2015 ◽  
Vol 5 (105) ◽  
pp. 86179-86190 ◽  
Author(s):  
Sagnika Pradhan ◽  
B. G. Mishra
Keyword(s):  
Heterogeneous Catalyst ◽  
Mixed Oxides ◽  
Urea Hydrolysis ◽  
Environmentally Benign ◽  
One Pot ◽  
Hydrolysis Method ◽  
One Pot Synthesis ◽  
Catalytic Application

A series of sulfate grafted Fe2O3–ZrO2mixed oxides (SFexZr) were prepared by urea hydrolysis method and studied as heterogeneous catalyst for synthesis of structurally diverse 1,8-dioxodecahydroacridines.

An efficient multicomponent, one-pot synthesis of Betti bases catalyzed by cerium (IV) ammonium nitrate (CAN) at ambient temperature

2016 ◽  
Vol 5 (4) ◽  
Author(s):  
Ramadan Ahmed Mekheimer ◽  
Abdullah Mohamed Asiri ◽  
Afaf Mohamed Abdel Hameed ◽  
Reham R. Awed ◽  
Kamal Usef Sadek
Keyword(s):  
Ambient Temperature ◽  
Environmental Pollution ◽  
Ammonium Nitrate ◽  
Room Temperature ◽  
Catalytic Amount ◽  
High Yield ◽  
Reaction Conditions ◽  
One Pot ◽  
Work Up ◽  
Cerium Iv Ammonium Nitrate

AbstractStarting from readily available 2-naphthol, aldehydes, aryl and alkylamines, a variety of Betti bases were efficiently synthesized utilizing a catalytic amount of cerium (IV) ammonium nitrate (CAN) at room temperature. This protocol has advantages of high yield, mild reaction conditions, no environmental pollution, diversity of reactants and simple work up procedure.

The One-Pot Synthesis of Pyridine Derivatives from The Corresponding 1,5-Dicarbonyl Compounds

Heterocycles ◽  
2019 ◽  
Vol 98 (10) ◽  
pp. 1375
Author(s):  
Hiroyuki Konno ◽  
Takeru Miyakoshi ◽  
Hiromichi Mihara ◽  
Yui Kikuchi
Keyword(s):  
Pyridine Derivatives ◽  
One Pot ◽  
Dicarbonyl Compounds ◽  
One Pot Synthesis ◽  
The One
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