A new efficient synthesis of α-methyl-β-ketoesters through an Eschenmoser sulfide reaction
Various α-methyl-β-ketoesters were readily synthesized through Eschenmoser condensation of thioamides with a commercially available bromoester. β-Enaminoesters were easily prepared through this sulfide contraction reaction and were hydrolysed to afford the corresponding β-ketoesters in moderate to good yields.Key words: α-alkylated-β-ketoesters, Eschenmoser, β-enaminoesters.
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2013 ◽
Vol 33
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pp. 523-529
2014 ◽
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