Single-ion mass spectrometry at 100 ppt and beyond

2002 ◽  
Vol 80 (11) ◽  
pp. 1329-1336 ◽  
Author(s):  
S Rainville ◽  
J K Thompson ◽  
D E Pritchard
Keyword(s):  
Mass Spectrometry ◽  
Penning Trap ◽  
State Of The Art ◽  
Normal Modes ◽  
Mass Ratio ◽  
Current State ◽  
Order Of Magnitude ◽  
And Control ◽  
Source Of Error ◽  
Do So

Using a Penning trap single-ion mass spectrometer, we measured the atomic masses of 14 isotopes with a fractional accuracy of ~10–10. The precision on these measurements was limited by the temporal fluctuations of our magnetic field. By trapping two different ions in the same Penning trap at the same time, we have recently been able to virtually eliminate that source of error. We can now simultaneously measure the ratio of the two ion's cyclotron frequencies (from which we obtain their atomic mass ratio) with a precision of about 10–11 in only a few hours. To perform these comparisons, we must be able to measure and control all three normal modes of motion of each ion — cyclotron, axial, and magnetron — and have developed novel techniques to do so. This new technique shows promise of expanding the precision of mass spectrometry by an order of magnitude beyond the current state-of-the-art. PACS Nos.: 32.10Bi, 06.20Jr, 06.30Dr, 07.75+h, 07.77-n

scholarly journals Design of Tendon-Driven Manipulators

1995 ◽  
Vol 117 (B) ◽  
pp. 80-86 ◽  
Author(s):  
Lung-Wen Tsai
Keyword(s):  
State Of The Art ◽  
Unique Characteristic ◽  
Current State ◽  
Dynamics And Control ◽  
And Control

This paper presents an overview of the current state-of-the-art in the design of tendon-driven manipulators. A special characteristic associated with tendon-driven manipulators is that tendons can only exert tension but not compression. Based on this unique characteristic, the fundamental mechanics associated with the design of tendon-driven manipulators are reviewed. The review includes structure classification, kinematics, statics, dynamics and control.

The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies

The Analyst ◽  
2018 ◽  
Vol 143 (11) ◽  
pp. 2459-2468 ◽  
Author(s):  
Yuwei Tian ◽  
Brandon T. Ruotolo
Keyword(s):  
Mass Spectrometry ◽  
State Of The Art ◽  
Therapeutic Antibodies ◽  
Critical Importance ◽  
Current State ◽  
Measurement Science ◽  
Structural Mass Spectrometry ◽  
Structural Mass

The comprehensive structural characterization of therapeutic antibodies is of critical importance for the successful discovery and development of such biopharmaceuticals, yet poses many challenges to modern measurement science. Here, we review the current state-of-the-art mass spectrometry technologies focusing on the characterization of antibody-based therapeutics.

scholarly journals Design of Tendon-Driven Manipulators

1995 ◽  
Vol 117 (B) ◽  
pp. 80-86 ◽  
Author(s):  
Lung-Wen Tsai
Keyword(s):  
State Of The Art ◽  
Unique Characteristic ◽  
Current State ◽  
Dynamics And Control ◽  
And Control

This paper presents an overview of the current state-of-the-art in the design of tendon-driven manipulators. A special characteristic associated with tendon-driven manipulators is that tendons can only exert tension but not compression. Based on this unique characteristic, the fundamental mechanics associated with the design of tendon-driven manipulators are reviewed. The review includes structure classification, kinematics, statics, dynamics and control.

An Impression of the Conference at St. Andrews

1968 ◽  
Vol 1 (1) ◽  
pp. 12-13
Author(s):  
L. Finkelstein
Keyword(s):  
Online Measurement ◽  
Information Revolution ◽  
Current State ◽  
The World ◽  
And Control ◽  
Rapid Presentation ◽  
Do So

All scientists and technologists nowadays, and especially, perhaps, those concerned with instrumentation and control, suffer from the information revolution. A flood of publications, ranging from the erudite to the popular, and from the useful to the trivial, pours from the presses of the world. It is in fact becoming impossible to read all the abstracts in one's field, let alone all the papers. Conscious of the need to keep up to date, we often resort to the Conference as a means of finding out about the current state in some area of our art or science. Too often we are disappointed. From the arrival of the bulky bundle of pre-prints, which we have no hope of reading with the attention they require, right through the rapid presentation of some very difficult material by a rapporteur, we grow ever more confused. At best we emerge having made or renewed some personal contacts. The picture presented is, of course, a caricature, but is I think close enough to reality to be recognisable. The S.I.T. Conference on “Online measurement and inspection: their impact on quality” has, however, shown that given determination to do so, it is still possible to mount a technical meeting at which you can actually follow and enjoy all the papers.

scholarly journals Assessing Sustainability in the Shipbuilding Supply Chain 4.0: A Systematic Review

2020 ◽  
Vol 12 (16) ◽  
pp. 6373 ◽  
Author(s):  
Magdalena Ramirez-Peña ◽  
Francisco J. Abad Fraga ◽  
Jorge Salguero ◽  
Moises Batista
Keyword(s):  
Systematic Review ◽  
Supply Chain ◽  
Scientific Community ◽  
State Of The Art ◽  
Current State ◽  
Enabling Technologies ◽  
Global Vision ◽  
The Subject ◽  
Key Enabling Technologies ◽  
Do So

The supply chain is currently taking on a very important role in organizations seeking to improve the competitiveness and profitability of the company. Its transversal character mainly places it in an unbeatable position to achieve this role. This article, through a study of each of the key enabling technologies of Industry 4.0, aims to obtain a general overview of the current state of the art in shipbuilding adapted to these technologies. To do so, a systematic review of what the scientific community says is carried out, dividing each of the technologies into different categories. In addition, the global vision of countries interested in each of the enabling technologies is also studied. Both studies present a general vision to the companies of the concerns of the scientific community, thus encouraging research on the subject that is focused on the sustainability of the shipbuilding supply chain.

scholarly journals Nanoscale rippling on polymer surfaces induced by AFM manipulation

2015 ◽  
Vol 6 ◽  
pp. 2278-2289 ◽  
Author(s):  
Mario D’Acunto ◽  
Franco Dinelli ◽  
Pasqualantonio Pingue
Keyword(s):  
State Of The Art ◽  
Theoretical Models ◽  
Polymer Surfaces ◽  
Full Understanding ◽  
Polymeric Surfaces ◽  
Atomic Force ◽  
Current State ◽  
Heating Up ◽  
And Control ◽  
Nanoscale Level

Nanoscale rippling induced by an atomic force microscope (AFM) tip can be observed after performing one or many scans over the same area on a range of materials, namely ionic salts, metals, and semiconductors. However, it is for the case of polymer films that this phenomenon has been widely explored and studied. Due to the possibility of varying and controlling various parameters, this phenomenon has recently gained a great interest for some technological applications. The advent of AFM cantilevers with integrated heaters has promoted further advances in the field. An alternative method to heating up the tip is based on solvent-assisted viscoplastic deformations, where the ripples develop upon the application of a relatively low force to a solvent-rich film. An ensemble of AFM-based procedures can thus produce nanoripples on polymeric surfaces quickly, efficiently, and with an unprecedented order and control. However, even if nanorippling has been observed in various distinct modes and many theoretical models have been since proposed, a full understanding of this phenomenon is still far from being achieved. This review aims at summarizing the current state of the art in the perspective of achieving control over the rippling process on polymers at a nanoscale level.

The Present State of Autonomous Underwater Vehicle (AUV) Applications and Technologies

2008 ◽  
Vol 42 (1) ◽  
pp. 44-51 ◽  
Author(s):  
J. W. Nicholson ◽  
A. J. Healey
Keyword(s):  
Present State ◽  
Autonomous Underwater Vehicle ◽  
State Of The Art ◽  
Underwater Vehicle ◽  
The State ◽  
Design Features ◽  
Current State ◽  
Do So

AUVs have proved their usefulness in recent years and continue to do so. This paper is a review of the current state of the art of AUVs. Present AUV capabilities are reviewed through a discussion of feasible present-day AUV missions. The state of key AUV design features and sensor technologies is also addressed, identifying those areas most critical to continued future progress in AUV development.

scholarly journals Gamificação e realidade aumentada em processos de ensino-aprendizagem: uma revisão sistemática da literatura

2021 ◽  
Vol 14 (2) ◽  
pp. 262-274
Author(s):  
Orlando Rosa Junior ◽  
Tiago De Oliveira ◽  
Ezequiel Zorzal
Keyword(s):  
Augmented Reality ◽  
State Of The Art ◽  
Learning Assessment ◽  
Assessment Methodology ◽  
Know How ◽  
Current State ◽  
Research Questions ◽  
Programming Knowledge ◽  
Specific Learning ◽  
Do So

This paper presents a Systematic Literature Review (RSL) on the use of Gamification and Augmented Reality applied in Education. RSL enabled mapping and knowledge of the current state of related studies. Thirty articles related to the state of the art were analyzed. From the analysis, it was found that there is no specific learning assessment methodology when applying the Augmented Reality and Gamification tools. An analysis of the results was made to answer the research questions. The study showed that lack of programming knowledge is also a factor that hinders the advancement of research since the researcher must know how to develop the application or have in his team someone who has the competence to do so. Finally, we present the comparatives and analyzes of the studies to obtain answers based on the research questions developed.

scholarly journals SWIM: A Simple Word Interaction Model for Implicit Discourse Relation Recognition

2017 ◽  
Author(s):  
Wenqiang Lei ◽  
Xuancong Wang ◽  
Meichun Liu ◽  
Ilija Ilievski ◽  
Xiangnan He ◽  
...  
Keyword(s):  
Short Term Memory ◽  
State Of The Art ◽  
Interaction Model ◽  
Weighted Averaging ◽  
Short Term ◽  
Current State ◽  
Proposed Model ◽  
Order Of Magnitude ◽  
Long Short Term Memory ◽  
Semantic Interaction

Capturing the semantic interaction of pairs of words across arguments and proper argument representation are both crucial issues in implicit discourse relation recognition. The current state-of-the-art represents arguments as distributional vectors that are computed via bi-directional Long Short-Term Memory networks (BiLSTMs), known to have significant model complexity.In contrast, we demonstrate that word-weighted averaging can encode argument representation which can incorporate word pair information efficiently. By saving an order of magnitude in parameters, our proposed model achieves equivalent performance, but trains seven times faster.

scholarly journals The state of the art in plant lipidomics

2021 ◽  
Author(s):  
Cheka Kehelpannala ◽  
Thusitha Rupasinghe ◽  
Thomas Hennessy ◽  
David Bradley ◽  
Berit Ebert ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Critical Appraisal ◽  
State Of The Art ◽  
Lipid Analysis ◽  
The State ◽  
Future Trends ◽  
Liquid Chromatography Mass Spectrometry ◽  
Plant Lipid ◽  
Current State

In this review, we provide a critical appraisal of the key developments, current state and future trends in liquid-chromatography–mass spectrometry-based workflows for plant lipid analysis.

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