Regulation of transcription by an RNA polymerase II CTD phosphatase

1999 ◽  
Vol 77 (4) ◽  
pp. 398
Author(s):  
Michael S Kobor ◽  
Jacques Archambault ◽  
David Jansma ◽  
William Lester ◽  
Lisa Simon ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Regulation Of Transcription ◽  
Ctd Phosphatase ◽  
Rna Polymerase Ii Ctd

scholarly journals RNA Polymerase II CTD phosphatase Rtr1 fine-tunes transcription termination

PLoS Genetics ◽  
2020 ◽  
Vol 16 (3) ◽  
pp. e1008317 ◽  
Author(s):  
Jose F. Victorino ◽  
Melanie J. Fox ◽  
Whitney R. Smith-Kinnaman ◽  
Sarah A. Peck Justice ◽  
Katlyn H. Burriss ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Transcription Termination ◽  
Ctd Phosphatase ◽  
Rna Polymerase Ii Ctd

scholarly journals The Structure of Fcp1, an Essential RNA Polymerase II CTD Phosphatase

2008 ◽  
Vol 32 (4) ◽  
pp. 478-490 ◽  
Author(s):  
Agnidipta Ghosh ◽  
Stewart Shuman ◽  
Christopher D. Lima
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Ctd Phosphatase ◽  
Rna Polymerase Ii Ctd

Inhibition of Tat transactivation by the RNA polymerase II CTD-phosphatase FCP1

AIDS ◽  
2001 ◽  
Vol 15 (3) ◽  
pp. 301-307 ◽  
Author(s):  
Paolo Licciardo ◽  
Giuliana Napolitano ◽  
Barbara Majello ◽  
Luigi Lania
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Ctd Phosphatase ◽  
Rna Polymerase Ii Ctd

scholarly journals Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1

RNA ◽  
2015 ◽  
Vol 21 (6) ◽  
pp. 1135-1146 ◽  
Author(s):  
Beate Schwer ◽  
Agnidipta Ghosh ◽  
Ana M. Sanchez ◽  
Christopher D. Lima ◽  
Stewart Shuman
Keyword(s):  
Structural Analysis ◽  
Rna Polymerase ◽  
Fission Yeast ◽  
Rna Polymerase Ii ◽  
Ctd Phosphatase ◽  
Rna Polymerase Ii Ctd

scholarly journals Ssu72 Is an RNA Polymerase II CTD Phosphatase

2004 ◽  
Vol 14 (3) ◽  
pp. 387-394 ◽  
Author(s):  
Shankarling Krishnamurthy ◽  
Xiaoyuan He ◽  
Mariela Reyes-Reyes ◽  
Claire Moore ◽  
Michael Hampsey
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Ctd Phosphatase ◽  
Rna Polymerase Ii Ctd

scholarly journals Genetic Interactions of Spt4-Spt5 and TFIIS With the RNA Polymerase II CTD and CTD Modifying Enzymes in Saccharomyces cerevisiae

Genetics ◽  
2001 ◽  
Vol 159 (2) ◽  
pp. 487-497 ◽  
Author(s):  
Derek L Lindstrom ◽  
Grant A Hartzog
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Transcription Elongation ◽  
Normal Function ◽  
Genetic Interactions ◽  
Elongation Factors ◽  
Repeat Domain ◽  
Ctd Phosphatase ◽  
Rna Polymerase Ii Ctd

Abstract Genetic and biochemical studies have identified many factors thought to be important for transcription elongation. We investigated relationships between three classes of these factors: (1) transcription elongation factors Spt4-Spt5, TFIIS, and Spt16; (2) the C-terminal heptapeptide repeat domain (CTD) of RNA polymerase II; and (3) protein kinases that phosphorylate the CTD and a phosphatase that dephosphorylates it. We observe that spt4 and spt5 mutations cause strong synthetic phenotypes in combination with mutations that shorten or alter the composition of the CTD; affect the Kin28, Bur1, or Ctk1 CTD kinases; and affect the CTD phosphatase Fcp1. We show that Spt5 co-immunoprecipitates with RNA polymerase II that has either a hyper- or a hypophosphorylated CTD. Furthermore, mutation of the CTD or of CTD modifying enzymes does not affect the ability of Spt5 to bind RNA polymerase II. We find a similar set of genetic interactions between the CTD, CTD modifying enzymes, and TFIIS. In contrast, an spt16 mutation did not show these interactions. These results suggest that the CTD plays a key role in modulating elongation in vivo and that at least a subset of elongation factors are dependent upon the CTD for their normal function.

scholarly journals Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast

2019 ◽  
Vol 294 (44) ◽  
pp. 16080-16094 ◽  
Author(s):  
Maria J. Aristizabal ◽  
Kristy Dever ◽  
Gian Luca Negri ◽  
Mary Shen ◽  
Nicole Hawe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Induced Genes ◽  
Ctd Phosphatase ◽  
Rna Polymerase Ii Ctd
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