The role of clusterin in tissue injury

1994 ◽  
Vol 72 (11-12) ◽  
pp. 483-488 ◽  
Author(s):  
John R. Silkensen ◽  
Gary B. Schwochau ◽  
Mark. E. Rosenberg
Keyword(s):  
Myocardial Infarction ◽  
Renal Disease ◽  
Tissue Injury ◽  
Cell Interactions ◽  
Tubular Injury ◽  
Disease States ◽  
Wide Range ◽  
Cystic Renal Disease ◽  
Renal Tubular

Clusterin is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. The expression of clusterin in these states is intriguing given the apparent incongruity of the conditions listed, the variety of stimuli eliciting such expression, and the multiple proposed roles once induced. This review will outline the conditions associated with clusterin induction and speculate on its role in disease.Key words: clusterin, cell interactions, complement, injury, lipoprotein.

scholarly journals Presentation of the Child with Renal Disease and Guidelines for Referral to the Pediatric Nephrologist

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Amin J. Barakat
Keyword(s):  
Urinary Tract ◽  
Renal Disease ◽  
Systemic Disease ◽  
Renal Involvement ◽  
Signs And Symptoms ◽  
Pediatric Nephrologist ◽  
Modes Of Presentation ◽  
Renal Tubular ◽  
High Index Of Suspicion

Renal disease is a major cause of morbidity and mortality. Pediatric patients with renal disease, especially younger ones may present with nonspecific signs and symptoms unrelated to the urinary tract. Pediatricians, therefore, should be familiar with the modes of presentation of renal disease and should have a high index of suspicion of these conditions. Affected patients may present with signs and symptoms of the disease, abnormal urinalysis, urinary tract infection, electrolyte and acid-base abnormalities, decreased renal function, renal involvement in systemic disease, glomerular and renal tubular diseases, congenital abnormalities, and hypertension. Pediatricians may initiate evaluation of renal disease to the extent that they feel comfortable with. The role of the pediatrician in the management of the child with renal disease and guidelines for patient referral to the pediatric nephrologist are presented.

scholarly journals Renal tubular injury induced by glyphosate combined with hard water: the role of cytosolic phospholipase A2

2021 ◽  
Vol 9 (2) ◽  
pp. 130-130
Author(s):  
Ruojing Wang ◽  
Jing Chen ◽  
Fan Ding ◽  
Lin Zhang ◽  
Xuan Wu ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Hard Water ◽  
Cytosolic Phospholipase A2 ◽  
Tubular Injury ◽  
Cytosolic Phospholipase ◽  
Renal Tubular

scholarly journals Role of p53/miR-155-5p/sirt1 loop in renal tubular injury of diabetic kidney disease

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Yue Wang ◽  
Zong-ji Zheng ◽  
Yi-jie Jia ◽  
Yan-lin Yang ◽  
Yao-ming Xue
Keyword(s):  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Tubular Injury ◽  
Diabetic Kidney ◽  
Renal Tubular

scholarly journals Protective Role of Vitamin D in Renal Tubulopathies

Metabolites ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 115 ◽  
Author(s):  
Guido Gembillo ◽  
Valeria Cernaro ◽  
Rossella Siligato ◽  
Francesco Curreri ◽  
Antonino Catalano ◽  
...  
Keyword(s):  
Vitamin D ◽  
Protective Role ◽  
Inflammatory Factors ◽  
Tubular Injury ◽  
Dihydroxyvitamin D3 ◽  
Damage Response ◽  
Regulation Mechanisms ◽  
Renal Tubular ◽  
The Right

Vitamin D is tightly linked with renal tubular homeostasis: the mitochondria of proximal convoluted tubule cells are the production site of 1α,25-dihydroxyvitamin D3. Patients with renal impairment or tubular injury often suffer from chronic inflammation. This alteration comes from oxidative stress, acidosis, decreased clearance of inflammatory cytokines and stimulation of inflammatory factors. The challenge is to find the right formula for each patient to correctly modulate the landscape of treatment and preserve the essential functions of the organism without perturbating its homeostasis. The complexity of the counter-regulation mechanisms and the different axis involved in the Vitamin D equilibrium pose a major issue on Vitamin D as a potential effective anti-inflammatory drug. The therapeutic use of this compound should be able to inhibit the development of inflammation without interfering with normal homeostasis. Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects.

Exaggerated Fractional Sodium Excretion in Hypertension with Advanced Renal Disease: The Role of Renal Prostaglandin and Kallikrein

1981 ◽  
Vol 61 (s7) ◽  
pp. 327s-330s ◽  
Author(s):  
Keishi Abe ◽  
Yutaka Imai ◽  
Makito Sato ◽  
Toshiaki Haruyama ◽  
KO Sato ◽  
...  
Keyword(s):  
Renal Disease ◽  
Urinary Excretion ◽  
Creatinine Clearance ◽  
Sodium Excretion ◽  
Prostaglandin E ◽  
Borderline Hypertension ◽  
Fractional Sodium Excretion ◽  
Sustained Hypertension ◽  
Renal Tubular

1. The role of renal prostaglandin E (PGE) and kallikrein in the mechanism of the exaggerated fractional sodium excretion in hypertensive patients with advanced renal disease was investigated. 2. Urinary excretion of PGE and kallikrein was significantly decreased in patients with sustained hypertension. 3. Four times higher values for fractional sodium excretion and four or five times higher values for the urinary excretion of PGE corrected for creatinine clearance were found in patients with sustained hypertension. There was a significant positive correlation (r = 0.677) between the two, suggesting that PGE in the renal tubular compartment may be involved in the mechanism of the exaggerated fractional Na excretion in patients with advanced renal disease. 4. The urinary excretion rate of kallikrein corrected for creatinine clearance was three times greater in patients with borderline hypertension, but not significantly increased in those with sustained hypertension, compared with that in healthy volunteers.

Protective Role of Apelin Against Cyclosporine-Induced Renal Tubular Injury in Rats

2017 ◽  
Vol 49 (6) ◽  
pp. 1499-1509 ◽  
Author(s):  
J.S. Kim ◽  
J.W. Yang ◽  
B.G. Han ◽  
H.J. Kwon ◽  
J.H. Kim ◽  
...  
Keyword(s):  
Protective Role ◽  
Tubular Injury ◽  
Renal Tubular

scholarly journals CIRCULAR RNA – miRNA MEDIATED INTERACTION IN MYOCARDIAL INFARCTION

2021 ◽  
Vol 27 (2) ◽  
pp. 3793-3798
Author(s):  
Yordanka Doneva ◽  
◽  
Veselin Valkov ◽  
Yavor Kashlov ◽  
Galya Mihaylova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Myocardial Infarction ◽  
Circular Rna ◽  
Biological Functions ◽  
Non Coding Rna ◽  
Circular Structure ◽  
Wide Range ◽  
Non Coding Rnas ◽  
Long Non Coding Rna

Circular RNA (circRNAs) belong to the long non-coding RNA family, but unlike the linear RNA in circular RNA, the 3’ and 5’ end in the RNA molecule are joined together, forming their circular structure. Until recently, circRNAs have been believed to be a side product of splicing, but now it is known that they have a wide range of biological functions, from regulators of gene expression to regulators of other non-coding RNAs - microRNAs (miRNAs). CircRNAs have the potential of being therapeutic targets and biomarkers for diseases. There are little data and only several investigations about this type of RNAs in myocardial infarction in humans. This review summarizes the role of some new circRNA – miRNA interactions in the development of Myocardial Infarction.

scholarly journals The Role of non-coding RNA in Cardiac Repair and Regeneration after Myocardial Infarction

2021 ◽  
Vol 04 (06) ◽  
pp. 01-13
Author(s):  
Yongjun Li
Keyword(s):  
Myocardial Infarction ◽  
Life Quality ◽  
Circular Rna ◽  
Myocardial Repair ◽  
Non Coding Rna ◽  
Incidence And Mortality ◽  
Wide Range ◽  
High Incidence ◽  
Long Non Coding Rna

Myocardial infarction (MI), one of the cardiovascular diseases (CVDs) with high incidence and mortality rate, seriously endangers human health. The poor ways of fully repairing and regenerating the infarcted myocardium may have an impact on people's life quality, therefore scientists have devoted continuously to exploring the way of myocardial repair after MI so as to strive for a better prognosis of these patients. In recent years, non-coding RNAs (ncRNAs) have been identified and become one of the exciting fields of research in the development of CVDs. In a wide range of areas, more and more research has found that ncRNAs play important roles in myocardial repair. This review mainly introduces some strategies for myocardial repair and the role or mechanism of microRNA (miRNA), long non-coding RNA (lncRNA), circular RNA (circRNA) and circRNA/lncRNA-miRNA-mRNA regulatory axis in the repair of myocardial tissue after MI, in order to build a better understanding and find new therapeutic targets for MI.

scholarly journals Role of Rasa Vaha Srotas Dushti in Tvak Vikruti

2021 ◽  
Vol 9 (02) ◽  
Author(s):  
Vidya Y. Rao
Keyword(s):  
Psychosocial Factors ◽  
Dietary Habits ◽  
Skin Diseases ◽  
The Body ◽  
Dermatological Diseases ◽  
Disease States ◽  
Internal System ◽  
Wide Range

wholesome management of disease states which include diet, habit and medicine for total reversal of disease. Skin is the largest part of the body which is the protective covering as well as a reflection of the internal system. In Ayurveda various dermatological diseases discussed with its etiopathogenesis, classification and management and also described the wide range of etiological factors for Skin diseases including dietary habits and psychosocial factors. Tvak is the reflection of rasa dhatu sarata, hence any derangement in rasa dhatu function directly implies vitiation of quality of skin. The review is to unveil the importance of rasa dhatu dushti assessment in tvak roga which can help in both treatment aspects i.e. nidana parivarjana and samprapti vighattana.

Abstract P544: Osteopontin Deficiency Decreases Autophagy and Exacerbates Tubular Injury in Acute Kidney Injury Induced by Folic Acid

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Tomoaki Nagao ◽  
Takafumi Okura ◽  
Akiko Tanino ◽  
Ken-ichi Miyoshi ◽  
Masayoshi Kukida ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Folic Acid ◽  
Kidney Injury ◽  
Immunohistochemical Analysis ◽  
Tubular Injury ◽  
Histological Changes ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Renal Tubular

Osteopontin (OPN), a secreted glycosylated phosphoprotein and pro-inflammatory cytokine, has been implicated in the pathology of several renal conditions, especially renal fibrosis in chronic kidney disease. OPN is slightly expressed in renal tubular cells in normal condition, but after acute tubular injury, OPN is highly induced in these cells. However, the role of induced OPN is still unclear. The aim of this study was to clarify the roles of OPN in acute kidney injury (AKI). AKI was induced in wild type (WT) and OPN knockout (KO) mice by using folic acid (FA) injection (0.35mg/kg). After 2days of injection, 34% of WT mice died, whereas 54% of KO died from renal failure. Kidneys from survived mice were removed and the renal histological changes, protein expression were examined. BUN and Creatinine levels were markedly elevated in WT-AKI and KO-AKI mice (BUN: WT-sham; 25.7±4.7mg/dl, WT-AKI; 315.0±173.2mg/dl, KO-AKI; 337.7±163.7mg/dl, Creatinine: WT-sham; 0.08±0.03 mg/dl, WT-AKI; 1.60±0.87 mg/dl, KO-AKI; 1.80±0.94 mg/dl). Renal OPN mRNA expression was increased in WT-AKI mice compared to WT-sham mice (p<0.05). High levels of OPN expression in renal tubular cells were induced in WT-AKI mice. TUNEL positive tubular cells were increased in KO-AKI mice compared to WT-AKI mice. In immunohistochemical analysis, Kidney injury molecules 1 (Kim-1) positive tubular cells were also highly increased in KO-AKI mice compared to WT-AKI mice. In contrast, LC3B (autophagy related protein) positive tubular cells were decreased in KO-AKI mice compared to WT-AKI mice. These results indicate that OPN deficiency exacerbates tubular injury via through the inhibiting autophagy in folic acid induced AKI mice.

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