Etude conformationnelle par résonance magnétique nucléaire du carbone 13 de peptides à activité antalgique

1980 ◽  
Vol 58 (11) ◽  
pp. 1241-1246 ◽  
Author(s):  
Robert René Smolders ◽  
Roland Coomans ◽  
Françoise Jacquemotte ◽  
Yves Van Haverbeke ◽  
André Maquestiau ◽  
...  

13C Nuclear magnetic resonance studies of proline peptides with central antalgic activity (Pro-Arg, Arg-Pro, Pro-Arg-Pro, Pro-Lys-Pro) indicate a predominance of trans conformation at all pH values; but their physiological activities appear to be related to the ability of the C-terminal proline peptides to assume the cis conformation.

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