The Development of Kinetic Parameters of Hepatic Drug-Metabolizing Enzymes in Perinatal Rats

1975 ◽  
Vol 53 (4) ◽  
pp. 433-437 ◽  
Author(s):  
J. U. Bell ◽  
D. J. Ecobichon
Keyword(s):  
Kinetic Parameters ◽  
Wistar Rats ◽  
Drug Metabolizing Enzymes ◽  
Hepatic Enzymes ◽  
Metabolizing Enzymes ◽  
Hepatic Drug ◽  
Apparent Kinetic Parameters ◽  
Quantitative Changes ◽  
Functionally Diverse ◽  
Conjugating Enzyme

The development of the apparent kinetic parameters Km and Vmax was studied in perinatal Wistar rats for three functionally diverse, hepatic enzymes (p-nitroanisole O-demethylase, carboxylesterase and bromosulphophthalein–glutathione conjugating enzyme), the period studied being from 3 days prepartum to 35 days postpartum. The kinetic parameters underwent marked quantitative changes during development, which appeared to be independent of sex for the first 5 weeks postpartum.

The development of hepatic drug-metabolizing enzymes in perinatal guinea pigs: A biochemical and morphological study

1978 ◽  
Vol 56 (7) ◽  
pp. 738-745 ◽  
Author(s):  
D. J. Ecobichon ◽  
R. W. Dykeman ◽  
M. M. Hansell
Keyword(s):  
Guinea Pigs ◽  
Morphological Study ◽  
Smooth Endoplasmic Reticulum ◽  
Electron Microscopic Examination ◽  
Hepatic Enzymes ◽  
Electron Microscopic ◽  
Metabolizing Enzymes ◽  
Hepatic Drug ◽  
Enzymatic Systems ◽  
Functionally Diverse

The development of four functionally diverse, hepatic enzymes (p-nitroanisole O-demethylase, aniline hydroxylase, carboxylesterase, and glucuronyltransferase (with α-naphthol as the aglycone acceptor)) was studied in perinatal Hartley guinea pigs from 8 days prepartum to 28 days postpartum. A good correlation was observed between the activities measured in resuspended Ca2+-aggregated microsomes and the quantities of hepatic smooth endoplasmic reticulum visible by electron microscopic examination at the different stages of development. The study demonstrated that, postnatally, the guinea pig developed competent enzymatic systems as rapidly as did other laboratory species but that, prenatally, these same enzyme(s) systems were much further advanced than those in other species.

Tea consumption modulates hepatic drug metabolizing enzymes in Wistar rats

2001 ◽  
Vol 53 (4) ◽  
pp. 569-577 ◽  
Author(s):  
Pius P. Maliakal ◽  
Peter F. Coville ◽  
Sompon Wanwimolruk
Keyword(s):  
Wistar Rats ◽  
Drug Metabolizing Enzymes ◽  
Tea Consumption ◽  
Metabolizing Enzymes ◽  
Hepatic Drug

Comparative inhibitory effects of mefloquine and primaquine on hepatic drug-metabolizing enzymes

1990 ◽  
Vol 39 (1) ◽  
pp. 212-216 ◽  
Author(s):  
Thananda Sukhumanan ◽  
Wichitra Suphakawanich ◽  
Amnuay Thithapandha
Keyword(s):  
Drug Metabolizing Enzymes ◽  
Inhibitory Effects ◽  
Metabolizing Enzymes ◽  
Hepatic Drug

Induction of hepatic drug metabolizing enzymes in mammals by pesticides: A review

1980 ◽  
Vol 15 (6) ◽  
pp. 723-754 ◽  
Author(s):  
Ernest Hodgson ◽  
Arun P. Kulkarni ◽  
David L. Fabacher ◽  
Karen M. Robacker
Keyword(s):  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Hepatic Drug

Microscope immersion oils: effects of skin application on cutaneous and hepatic drug-metabolizing enzymes

1975 ◽  
Vol 24 (7) ◽  
pp. 779-783 ◽  
Author(s):  
David R. Bickers ◽  
Julie Eiseman ◽  
Attallah Kappas ◽  
Alvito P. Alvares
Keyword(s):  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Hepatic Drug

Effects of Garlic Powders with Varying Alliin Contents on Hepatic Drug Metabolizing Enzymes in Rats

2003 ◽  
Vol 51 (26) ◽  
pp. 7617-7623 ◽  
Author(s):  
Anne-Marie Le Bon ◽  
Marie-France Vernevaut ◽  
Lucien Guenot ◽  
Remi Kahane ◽  
Jacques Auger ◽  
...  
Keyword(s):  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Hepatic Drug
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