Metabolism, Distribution, and Disappearance of Infected β-Phenylethylamine in the Rat

1975 ◽  
Vol 53 (1) ◽  
pp. 42-50 ◽  
Author(s):  
P. H. Wu ◽  
Alan A. Boulton
Keyword(s):  
Monoamine Oxidase ◽  
Intravenous Injection ◽  
Phenylacetic Acid ◽  
Monoamine Oxidase Inhibitor ◽  
Brain Regions ◽  
Oxidase Inhibitor ◽  
Presence And Absence ◽  
Intravenous Introduction

In the absence of a monoamine oxidase inhibitor, the bulk of intravenously injected radioactively labelled β-phenylethylamine was oxidized to phenylacetic acid. In the presence of pargyline, most of the label in tissues remained as unchanged phenylethylamine; small amounts of labelled phenylethanolamine, tyramine and octopamine were also identified. After intravenous injection of [14C]phenylalanine, only very small amounts of [14C]phenylethylamine could be located in urine and faeces. β-Phenylethylamine became concentrated in all tissues, including brain, following intravenous introduction both in the presence and absence of pargyline. Its clearance from these tissues and from brain regions was very fast.

Distribution, Metabolism, and Disappearance of Intraventricularly Injected p-Tyramine in the Rat

1974 ◽  
Vol 52 (5) ◽  
pp. 374-381 ◽  
Author(s):  
P. H. Wu ◽  
Alan A. Boulton
Keyword(s):  
Cerebral Cortex ◽  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Brain Regions ◽  
Oxidase Inhibitor ◽  
Neutral Fraction ◽  
First Order ◽  
Metabolic Products ◽  
Hydroxyphenylacetic Acid ◽  
Presence And Absence

The major cerebral metabolic products of intraventricularly injected p-tyramine were octopamine and p-hydroxyphenylacetaldehyde. Only tiny amounts of p-hydroxyphenylacetic acid and p-hydroxyphenylethanol were found and these were located in the cerebral cortex (i.e. 'rest'). In brain regions isolated in the absence of pargyline the principal metabolite was p-hydroxyphenylacetaldehyde recovered in an acidic–neutral fraction; in the presence of pargyline, however, the majority of the label was associated with the amines tyramine and octopamine. In the caudate nucleus octopamine was essentially absent both in the presence and absence of pargyline.The loss of octopamine from all regions in the presence of pargyline was approximately exponential (i.e. first order) whereas in the absence of the monoamine oxidase inhibitor the loss was more complicated than first order. In most cases the loss of p-tyramine was greater than first order. Approximate half-lives based on these clearance values indicated a rapid turnover for p-tyramine and octopamine in all regions both in the presence and absence of pargyline.

Possible antidepressant/mania-inducing effects of methionine: a reappraisal of the effects of methionine in chronic psychosis using modern diagnostic criteria

1989 ◽  
Vol 4 (3) ◽  
pp. 175-181
Author(s):  
J.F. Lipinski ◽  
R.C. Alexander
Keyword(s):  
Monoamine Oxidase ◽  
Diagnostic Criteria ◽  
Monoamine Oxidase Inhibitor ◽  
Manic Episode ◽  
Oxidase Inhibitor ◽  
Descriptive Data ◽  
Antidepressant Effects ◽  
Chronic Psychosis

SummaryThe authors have reviewed 13 published studies on methionine administration, usually in combination with a monoamine oxidase inhibitor (MAOI), to chronically psychotic patients, using modern (DSM-III) diagnostic criteria. Four of these studies contained sufficient descriptive data to allow reappraisal of the effects. The results of the review suggest that a proportion of the patients experienced the induction of a manic episode/antidepressant effects rather than the reported worsening of schizophrenia while treated with a methionine-MAOI combination. It is suggested that these observations are consistent with recent findings that S-adenosyl-L-methionine (SAMe) has antidepressant and mania-inducing effects.

ROLE OF AN ENDOGENOUS MONOAMINE OXIDASE INHIBITOR, ISATIN, IN SHRSP BRAIN

1995 ◽  
Vol 22 (s1) ◽  
pp. S86-S87 ◽  
Author(s):  
N. Hamaue ◽  
T. Endo ◽  
M. Hirafuji ◽  
N. Yamazaki ◽  
H. Togashi ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor

Monoamine oxidase inhibitor usage in Hawaii

2010 ◽  
Vol 3 (4) ◽  
pp. 213-215
Author(s):  
Junji Takeshita ◽  
Deborah Goebert ◽  
John Huh ◽  
Brett Lu ◽  
Diane Thompson ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor

Identification of Kaempferol as a Monoamine Oxidase Inhibitor and Potential Neuroprotectant in Extracts ofGinkgo BilobaLeaves

2000 ◽  
Vol 52 (4) ◽  
pp. 451-459 ◽  
Author(s):  
B. D. SLOLEY ◽  
L. J. URICHUK ◽  
P. MORLEY ◽  
J. DURKIN ◽  
J. J. SHAN ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor

Correlation of the Cerebral Biochemical and Functional Effects of Monoamine Oxidase Inhibitor Antidepressants

1962 ◽  
pp. 266-277
Author(s):  
Amedeo S. Marrazzi ◽  
E. Ross Hart ◽  
Jose M. Rodriguez ◽  
Melvyn I. Gluckman ◽  
Zola P. Horovitz ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor
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