Erratum: Secretion Rate of Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate in Benign Essential Hypertension as Compared to Normal Subjects

1972 ◽  
Vol 50 (1) ◽  
pp. 109-109
Author(s):  
A. Shao ◽  
W. Nowaczynski ◽  
O. Kuchel ◽  
J. Genest
Keyword(s):  
Essential Hypertension ◽  
Normal Subjects ◽  
Dehydroepiandrosterone Sulfate ◽  
Secretion Rate

Secretion rate of dehydroepiandrosterone and dehydroepiandrosterone sulfate in benign essential hypertension as compared to normal subjects

1970 ◽  
Vol 48 (12) ◽  
pp. 1308-1313 ◽  
Author(s):  
A. Shao ◽  
W. Nowaczynski ◽  
O. Kuchel ◽  
J. Genest
Keyword(s):  
Essential Hypertension ◽  
Isotope Dilution ◽  
Normal Subjects ◽  
Dehydroepiandrosterone Sulfate ◽  
Secretion Rate ◽  
Isotope Dilution Method ◽  
Dilution Method ◽  
Hypertensive Patients ◽  
Double Isotope ◽  
Column Chromatographic

A study of the secretion rate of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) in normal subjects and patients with benign essential hypertension by a double isotope dilution method showed a fivefold increase in the secretion rate of dehydroepiandrosterone (from 9.8 mg/day ± 3.1 mg/day S.D. to 52.0 mg/day ± 15.5 mg/day S.D.), and a sixfold increase of dehydroepiandrosterone sulfate in hypertensive patients (from 10.7 mg/day ± 2.9 mg/day S.D. to 60.7 mg/day ± 18.6 mg/day S.D.). This study was carried out following the administration of 14C-labelled DHEA and 3H-labelled DHEA-S and involved an initial column chromatographic separation of urinary DHEA-glucuronide and sulfate.

Postural Changes in Essential Hypertension under Treatment and their Effect on the Renogram

1971 ◽  
Vol 10 (01) ◽  
pp. 39-46
Author(s):  
C. Alexandrou ◽  
E. Papadakis ◽  
E. Gyftaki ◽  
J. Darsinos
Keyword(s):  
Renal Function ◽  
Essential Hypertension ◽  
Early Diagnosis ◽  
Postural Hypotension ◽  
Antihypertensive Treatment ◽  
Normal Subjects ◽  
Upright Position ◽  
Postural Changes ◽  
Significant Impairment

SummaryRadioisotope renograms were obtained in the upright and prone position in 9 normal subjects, in 5 patients with untreated essential hypertension and in 21 hypertensives under treatment, showing moderate postural hypotension.No significant renographic change were seen in the two positions in normal subjects and untreated hypertensives. Treated hypertensives with postural hypotension showed significant impairment of renal function in the upright position in 15 cases and no change in 6. Renal creatinine clearance was lower in the group that showed renographic changes. Renography in the upright position is suggested as a convenient test for early diagnosis and follow-up of the adverse effects of antihypertensive treatment.

A COMPARISON OF TWO METHODS FOR MEASUREMENT OF ALDOSTERONE SECRETION RATE IN MAN

1966 ◽  
Vol 53 (2) ◽  
pp. 177-188 ◽  
Author(s):  
P. Lund-Johansen ◽  
T. Thorsen ◽  
K. F. Støa
Keyword(s):  
Urinary Excretion ◽  
Normal Subjects ◽  
Secretion Rate ◽  
Aldosterone Secretion ◽  
Simple Method ◽  
Mean Values ◽  
Pathological Conditions ◽  
Significant Difference ◽  
Derivative Method ◽  
The Mean

ABSTRACT A comparison has been made between (A), a relatively simple method for the measurement of aldosterone secretion rate, based on paper chromatography and direct densitometry of the aldosterone spot and (B) a more elaborate isotope derivative method. The mean secretion rate in 9 normal subjects was 112 ± 26 μg per 24 hours (method A) and 135 ± 35 μg per 24 hours (method B). The »secretion rate« in one adrenalectomized subject after the intravenous injection of 250 μg of aldosterone was 230 μg per 24 hours (method A) and 294 μg per 24 hours (method B). There was no significant difference in the mean values, and correlation between the two methods was good (r = 0.80). It is concluded that the densitometric method is suitable for clinical purposes as well as research, being more rapid and less expensive than the isotope derivative method. Method A also measures the urinary excretion of the aldosterone 3-oxo-conjugate, which is of interest in many pathological conditions. The densitometric method is obviously the less sensitive and a prerequisite for its use is an aldosterone secretion of 20—30 μg per 24 hours. Lower values are, however, rare in adults.

scholarly journals Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China

2020 ◽  
Vol 21 (4) ◽  
pp. 147032032098131
Author(s):  
Yanrui Wu ◽  
Xingming Pan ◽  
Xiaoxiao Jin
Keyword(s):  
Essential Hypertension ◽  
Gene Polymorphisms ◽  
Minority Group ◽  
Normal Subjects ◽  
Nucleotide Polymorphisms ◽  
Remote Region ◽  
Kinin System ◽  
Average Blood Pressure ◽  
Genetic Impact ◽  
Kallikrein Kinin System

Objective: Prolylcarboxypeptidase (PRCP) is both involved in the Kallikrein-Kinin system (KKS) and renin-angiotensin-aldosterone system (RAAS). This study aimed to determine the genetic impact of PRCP gene polymorphisms on essential hypertension (EH) in an isolated population from a remote region of China. Methods: A haplotype-based study was investigated in 346 EH patients and 346 normal subjects and all samples were Hani minority residents in Southwest China. A total of 11 tag single nucleotide polymorphisms (SNPs) in PRCP gene were tested by polymerase chain reaction-restriction fragment length polymorphism method. Results: Single site analysis found that PRCP gene 3′UTR SNP rs3750931 was associated with EH. The minor allele G of rs3750931 was more prevalent in the EH patients compared to control subjects after Bonferroni correction ( p < 0.05). Moreover, the rs3750931 G allele carriers showed higher average blood pressure (BP) level among the subjects. The H2 (GAGCACTAACA) haplotype without rs3750931 G allele showed the protective effect for EH (OR = 0.68, 95 CI 0.54–0.85, p = 0.001). Conclusion: The present study indicated PRCP gene rs3750931 was associated with the risk of EH. This SNP G allele could be considered as one of risk markers for EH in Hani population.

scholarly journals The effect of age on active and cryoactivatable inactive plasma renin in normal subjects and patients with essential hypertension.

1981 ◽  
Vol 45 (11) ◽  
pp. 1231-1235 ◽  
Author(s):  
MITSUAKI NAKAMARU ◽  
TOSHIO OGIHARA ◽  
TAKESHI HATA ◽  
ANNA MARUYAMA ◽  
HIROSHI MIKAMI ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Plasma Renin ◽  
Normal Subjects ◽  
Effect Of Age

Effect of Age on Active and Inactive Plasma Renin in Normal Subjects and in Patients with Essential Hypertension*

1981 ◽  
Vol 29 (8) ◽  
pp. 379-382 ◽  
Author(s):  
Mitsuaki Nakamaru ◽  
Toshio Ogihara ◽  
Jitsuo Higaki ◽  
Takeshi Hata ◽  
Anna Maruyama ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Plasma Renin ◽  
Normal Subjects ◽  
Effect Of Age

scholarly journals Age versus urinary sodium for judging renin, aldosterone, and catecholamine levels: Studies in normal subjects and patients with essential hypertension

1978 ◽  
Vol 14 (6) ◽  
pp. 619-628 ◽  
Author(s):  
Peter Weidmann ◽  
Carlo Beretta-Piccoli ◽  
Walter H. Ziegler ◽  
Gerald Keusch ◽  
Zeev Glück ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Normal Subjects ◽  
Urinary Sodium ◽  
Catecholamine Levels
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