N6-(Δ2-Isopentenyl)adenosine: Its Conversion to Inosine, Catalyzed By Adenosine Aminohydrolases From Chicken Bone Marrow and Calf Intestinal Mucosa

1971 ◽  
Vol 49 (6) ◽  
pp. 623-630 ◽  
Author(s):  
Ross H. Hall ◽  
Syed N. Alam ◽  
B. D. McLennan ◽  
Claude Terrine ◽  
Jean Guern
Keyword(s):  
Bone Marrow ◽  
Intestinal Mucosa ◽  
Enzyme Preparation ◽  
Biological Behavior ◽  
Side Chain ◽  
Animal Tissues ◽  
Chicken Bone ◽  
Measurable Rate ◽  
Isopentenyl Adenosine ◽  
Derivatives Of

N6-(Δ2-Isopentenyl)adenosine, a component of tRNA, displays biological activity in both plant and animal systems. As part of a study of the biological behavior of this nucleoside, its degradation in animal tissues has been studied. An enzyme that catalyzes conversion of this nucleoside to inosine has been partially purified from chicken bone marrow. The enzyme preparation also catalyzes conversion of adenosine to inosine at about 40 times the rate of conversion of N6-(Δ2-isopentenyl)adenosine. A series of analogues of this nucleoside has been tested as substrates. The Δ3-isomer, n-pentyl, isopentyl, and furfuryl derivatives are readily cleaved. Hydroxylated derivatives of the Δ2-isopentenyl side chain, however, do not serve as substrates. Adenosine aminohydrolase from calf intestinal mucosa also catalyzes conversion of N6-(Δ2-isopentenyl)adenosine to inosine, although in order to obtain a measurable rate, the concentration of enzyme must be about 1000 times that needed to catalyze conversion of adenosine.

Dolichol: a curriculum cognitionis

1992 ◽  
Vol 70 (6) ◽  
pp. 377-381 ◽  
Author(s):  
Frank W. Hemming
Keyword(s):  
Biosynthetic Pathway ◽  
Side Chain ◽  
Plant Tissues ◽  
Animal Tissues ◽  
Dolichyl Phosphate ◽  
Putative Precursor ◽  
Eukaryotic Organisms ◽  
Derivatives Of ◽  
Long Chain

Dolichols were first described about 30 years ago when animal tissues were being examined for the presence of a putative precursor to the polyisoprenoid side chain of ubiquinone. These long-chain 2,3-dihydro-polycis-isoprenoid alcohols are found in all eukaryotic organisms. In many plant tissues they are accompanied by families of other polyisoprenoid alcohols that are usually similar molecules and possess an unsaturated α-isoprene residue. Analogy with the role of bactoprenyl phosphates in the synthesis of bacterial wall glycans led to the discovery that the mono- and di-phosphates of dolichols function as cofactors in protein N-glycosylation, involving the formation of glycosylated derivatives of dolichol as intermediates. Variation of the concentration of dolichyl phosphate was shown to be one way of controlling protein N-glycosylation. This can be achieved by modification of the relative activities of dolichol kinase and dolichol phosphate phosphatase. Modulation of the biosynthetic pathway, still not fully understood, of dolichyl phosphate may also be an important factor. Several disease conditions involve aberrations in these pathways.Key words: dolichols, polyisoprenoid alcohols, N-glycosylation, O-mannosylation.

Absolute configuration at C(20) of the derivatives of 21-nor-5α-cholane-20,24-diol

1980 ◽  
Vol 45 (9) ◽  
pp. 2443-2451
Author(s):  
Vladimír Pouzar ◽  
Miroslav Havel
Keyword(s):  
Absolute Configuration ◽  
Side Chain ◽  
Chemical Correlation ◽  
The Absolute ◽  
Derivatives Of

Derivatives of 21-nor-5α-cholane-20,24-diol XI and XIX were prepared by stepwise construction of the side-chain in the position 17β. Their absolute configuration at C(20) was determined on the basis of chemical correlation with the derivatives of 21-nor-5α-cholan-20-ol, XVI and XXIV. The absolute configuration of alcohols XVI and XXIV was determined from the ratio of the yields in which they are formed during the reduction of ketone X and using the benzoate rule. To compounds XI-XVIII the configuration 20R and to compounds XIX-XXVI the configuration 20S has been assigned.

scholarly journals Synthesis of New Derivatives of BEDT-TTF: Installation of Alkyl, Ethynyl, and Metal-Binding Side Chains and Formation of Tris(BEDT-TTF) Systems

2021 ◽  
Vol 7 (8) ◽  
pp. 110
Author(s):  
Songjie Yang ◽  
Matteo Zecchini ◽  
Andrew Brooks ◽  
Sara Krivickas ◽  
Desiree Dalligos ◽  
...  
Keyword(s):  
Metal Binding ◽  
Tricarboxylic Acid ◽  
Metal Salts ◽  
Side Chain ◽  
Side Chains ◽  
Ethynyl Group ◽  
X Ray ◽  
Transition Metal Salts ◽  
Alkyl Side Chains ◽  
Derivatives Of

The syntheses of new BEDT-TTF derivatives are described. These comprise BEDT-TTF with one ethynyl group (HC≡C-), with two (n-heptyl) or four (n-butyl) alkyl side chains, with two trans acetal (-CH(OMe)2) groups, with two trans aminomethyl (-CH2NH2) groups, and with an iminodiacetate (-CH2N(CH2CO2−)2 side chain. Three transition metal salts have been prepared from the latter donor, and their magnetic properties are reported. Three tris-donor systems are reported bearing three BEDT-TTF derivatives with ester links to a core derived from benzene-1,3,5-tricarboxylic acid. The stereochemistry and molecular structure of the donors are discussed. X-ray crystal structures of two BEDT-TTF donors are reported: one with two CH(OMe)2 groups and with one a -CH2N(CH2CO2Me)2 side chain.

ChemInform Abstract: A GENERAL SYNTHESIS OF SIDE CHAIN DERIVATIVES OF Δ9-THC

1978 ◽  
Vol 9 (12) ◽  
Author(s):  
C. G. PITT ◽  
H. H. SELTZMAN ◽  
Y. SAYED ◽  
C. E. JUN. TWINE ◽  
D. L. WILLIAMS
Keyword(s):  
Side Chain ◽  
Derivatives Of ◽  
General Synthesis

New 4-Hydroxypyridine and 4-Hydroxyquinoline Derivatives as Inhibitors of NADH-ubiquinone Reductase in the Respiratory Chain

1989 ◽  
Vol 44 (7-8) ◽  
pp. 609-616 ◽  
Author(s):  
Kun Hoe Chung ◽  
Kwang Yun Cho ◽  
Yasuko Asami ◽  
Nobutaka Takahashi ◽  
Shigeo Yoshida
Keyword(s):  
Electron Transport ◽  
Respiratory Chain ◽  
Side Chain ◽  
Pyridine Derivatives ◽  
Transport Function ◽  
Optimal Length ◽  
Structure Activity ◽  
Membrane Effect ◽  
Relationship Of ◽  
Derivatives Of

Many derivatives of 2,3-dim ethoxy-4-hydroxypyridine, which were designed from examination of the structure-activity relationship of piericidins, were tested for inhibition of NADH-UQ reductase. The lipophilic side chain of those compounds was indicated to be a key part for activity and its optimal length was conjectured. By the use of two different phases of assay material, intact mitochondria and submitochondria, the size of a membrane effect was shown to depend on the structure of the side chain. 4-Hydroxyquinoline derivatives were also tested for an analogous role in relation to the electron transport function of menaquinone, and they were proven to be inhibitors of NADH-UQ reductase as good as the pyridine derivatives.

New N.alpha.-Guanidinobenzoyl Derivatives of Hirudin-54-65 Containing Stabilized Carboxyl or Phosphoryl Groups on the Side Chain of Phenylalanine-63

1994 ◽  
Vol 37 (5) ◽  
pp. 625-629 ◽  
Author(s):  
Christophe Thurieau ◽  
Serge Simonet ◽  
Joseph Paladino ◽  
Jean-Francois Prost ◽  
Tony Verbeuren ◽  
...  
Keyword(s):  
Side Chain ◽  
Phosphoryl Groups ◽  
Derivatives Of

A Simple Method to Generate Side-Chain Derivatives of Regioregular Polythiophene via the GRIM Metathesis and Post-polymerization Functionalization

2003 ◽  
Vol 36 (1) ◽  
pp. 61-64 ◽  
Author(s):  
Lei Zhai ◽  
Richard L. Pilston ◽  
Karen L. Zaiger ◽  
Kristoffer K. Stokes ◽  
Richard D. McCullough
Keyword(s):  
Side Chain ◽  
Simple Method ◽  
Derivatives Of
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