Independence of growth hormone effects on nitrogen retention and free fatty acid mobilization

1968 ◽  
Vol 46 (10) ◽  
pp. 1269-1272 ◽  
Author(s):  
Jose S. Cheng ◽  
Norman Kalant
Keyword(s):  
Growth Hormone ◽  
Oxygen Consumption ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Respiratory Quotient ◽  
Nitrogen Retention ◽  
Plasma Free Fatty Acid ◽  
Suppressive Effect ◽  
Nitrogen Excretion ◽  
Ad Libitum

Bovine growth hormone (4 mg) was injected subcutaneously into two groups of rats, one group limited-fed and the other fed ad libitum. Four hours later, the respiratory quotient was found to be lowered and the plasma free fatty acid (FFA) level elevated. The oxidation rate of orally administered 14C-tripalmitin to 14CO2 and the oxygen consumption rate were not affected. Growth hormone administered for 9 days had a persistent suppressive effect on urinary nitrogen excretion and respiratory quotient in both groups but caused a maintained elevation of the plasma FFA level only in the ad libitum group. 14C-Tripalmitin oxidation and oxygen consumption rates were unaffected by growth hormone.

Plasma Free Fatty Acid Response to the Administration of Chorionic “Growth Hormone-Prolactin”

1966 ◽  
Vol 26 (4) ◽  
pp. 478-482 ◽  
Author(s):  
M. M. GRUMBACH ◽  
S. L. KAPLAN ◽  
C. L. ABRAMS ◽  
J. J. BELL ◽  
F. A. CONTE
Keyword(s):  
Growth Hormone ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Plasma Free Fatty Acid

Effect of glucagon on thermogenesis in the pigeon.

1977 ◽  
Vol 232 (5) ◽  
pp. E451
Author(s):  
E Hohtola ◽  
R Hissa ◽  
S Saarela
Keyword(s):  
Oxygen Consumption ◽  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Plasma Free Fatty Acid ◽  
Energy Reserves ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Plasma Ffa ◽  
Adrenergic Blocking

The effects of glucagon injection on temperature regulation and some metabolic parameters were studied in the pigeon. Glucagon (100 microng/kg) always inhibited shivering and caused a fall in the oxygen consumption and body temperature of the unanesthetized pigeon at + 6 degrees C. At + 34 degrees C, the same dose of glucagon had no effect on these parameters. At 22 degrees C, glucagon produced an elevation in plasma free fatty acid (FFA) and blood glucose levels. The rise in FFA at 22 degrees C coincided with the suppression of shivering at 6 degrees C. The glucagon-mediated rise in plasma FFA, but not glucose level, was potentiated by cold ambient temperature. Adrenergic blocking agents given prior to glucagon did not abolish its effects. Phentolamine even prolonged the absence and accelerated the suppression of shivering. A dissociation in the mechanisms by which catecholamines and glucagon suppress shivering is suggested. Although mobilizing energy reserves, glucagon does not seem to be calorigenic in the pigeon at this dose. The interpretation of the changes in plasma FFA levels is discussed in relation to fuel consumption during shivering.

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