BIOLOGICAL ACTIVITY OF CORTICOSTERONE AND 11-DEOXY-CORTICOSTERONE C-21 ESTER SULFATES COMPARED WITH THAT OF THE CORRESPONDING STEROID-FREE ALCOHOLS

1966 ◽  
Vol 44 (11) ◽  
pp. 1505-1509 ◽  
Author(s):  
G. P. Klein ◽  
C. J. P. Giroud
Keyword(s):  
Biological Activity ◽  
Liver Glycogen ◽  
Urinary Sodium ◽  
Sodium Potassium ◽  
Glycogen Deposition ◽  
Adrenalectomized Mouse ◽  
Mineralocorticoid Activity

Corticosterone-21-suifate was assayed for liver-glycogen deposition in the adrenalectomized mouse, and 11-deoxycorticosterone-21-sulfate for mineralocorticoid activity (urinary sodium/potassium) in the adrenalectomized rat. Compared with equimolar doses of corticosterone (140–870 mμmoles/mouse) and of 11-deoxycorticosterone (4.5–36.0 mμmoles/rat) the two conjugates were devoid of biological activity.

Carbohydrate metabolism of mice exposed to simulated changes in gravity

1964 ◽  
Vol 207 (2) ◽  
pp. 411-414 ◽  
Author(s):  
Jiro Oyama ◽  
William T. Platt
Keyword(s):  
Blood Glucose ◽  
Carbohydrate Metabolism ◽  
Exposure Time ◽  
Liver Glycogen ◽  
Critical Function ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference ◽  
Glycogen Deposition ◽  
Adrenal Corticosterone

Unrestrained mice were centrifuged for varying periods ranging from 0.5 to 10 hr at 2.5, 5, and 10 x gravity. Liver glycogen and blood glucose levels increased significantly depending on the g load and exposure time. Adrenalectomy completely abolished the glycogen deposition response. The glycogen response was a critical function of the age of mice; unweaned mice did not respond. Blood corticosterone increased significantly prior to the deposition of glycogen. Centrifuged fed mice deposited three times the amount of glycogen of fasted mice. There was no significant difference in the amount of glycogen deposited in centrifuged mice previously starved for 1, 2, or 3 days. It is concluded that the increased glycogen deposited following centrifugation is effected by an increased elaboration of adrenal corticosterone.

Dissociation between kallikrein and aldosterone in Cushing's disease with periodic hormonogenesis

1985 ◽  
Vol 110 (3) ◽  
pp. 296-301
Author(s):  
Axel Overlack ◽  
Miyoko Higuchi ◽  
Rainer Kolloch ◽  
Hans-Michael Müller ◽  
Klaus O. Stumpe ◽  
...  
Keyword(s):  
Negative Relationship ◽  
Cushing's Syndrome ◽  
Bilateral Adrenalectomy ◽  
Cushing's Disease ◽  
Prostaglandin E ◽  
Cortisol Secretion ◽  
Acth Secretion ◽  
Sodium Potassium ◽  
Cortisol Excretion ◽  
Mineralocorticoid Activity

Abstract. It has been suggested that the renal kallikreinkinin system is dependent on mineralocorticoid activity. This hypothesis was studied in a patient with cyclic Cushing's syndrome combined with cortisol suppressible, dexamethasone non-suppressible ACTH secretion. The 24-h urinary excretions of sodium, potassium, cortisol, active and inactive kallikrein, aldosterone, and prostaglandin E2 (PGE2) were studied during normal and excessive cortisol secretion and after bilateral adrenalectomy. Kallikrein, PGE2 and potassium rose during cortisol overproduction while aldosterone and sodium decreased. Kallikrein, PGE and potassium were positively related to cortisol excretion, whereas urinary aldosterone and sodium showed a negative relationship to cortisol. Kallikrein was inversely related to aldosterone. Excretion of inactive kallikrein followed closely the changes of active kallikrein. During cortisol excess, as in our patient, the mineralocorticoid activity of cortisol will exceed that of aldosterone. This suggests that the alterations in kallikrein, aldosterone and PGE2 during cortisol excess in the present study were due to the mineralocorticoid potency of the steroid.

A16050 Urinary sodium potassium excretion and blood pressure in Chinese living in nursing houses

2018 ◽  
Vol 36 ◽  
pp. e337
Author(s):  
Sufang Zhao ◽  
Hongye Zhang ◽  
Lisheng Liu ◽  
Yuehong Dong ◽  
Jinguo Zhao ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Urinary Sodium ◽  
Potassium Excretion ◽  
Sodium Potassium

Urinary Sodium, Potassium and Aldosterone in Duchenne Muscular Dystrophy1

1977 ◽  
Vol 44 (1) ◽  
pp. 185-188 ◽  
Author(s):  
JOSEPHINE B. GARST ◽  
PAUL J. VIGNOS ◽  
MAGDALENA HADADAY ◽  
DEAN N. MATTHEWS
Keyword(s):  
Urinary Sodium ◽  
Sodium Potassium

scholarly journals Association of Urinary Sodium/Potassium Ratio with Blood Pressure: Sex and Racial Differences

2011 ◽  
Vol 7 (2) ◽  
pp. 315-322 ◽  
Author(s):  
S. Susan Hedayati ◽  
Abu T. Minhajuddin ◽  
Adeel Ijaz ◽  
Orson W. Moe ◽  
Essam F. Elsayed ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Racial Differences ◽  
Urinary Sodium ◽  
Sodium Potassium

Measurement of hepatic Ra UDP-glucose in vivo in rats: relation to glycogen deposition and labeling patterns

1997 ◽  
Vol 272 (1) ◽  
pp. E155-E162 ◽  
Author(s):  
M. K. Hellerstein ◽  
A. Letscher ◽  
J. M. Schwarz ◽  
D. Cesar ◽  
C. H. Shackleton ◽  
...  
Keyword(s):  
Liver Glycogen ◽  
Hepatic Glycogen ◽  
Distribution Analysis ◽  
Basic Principles ◽  
Intravenous Glucose ◽  
Isotopic Method ◽  
Mass Isotopomer Distribution Analysis ◽  
Common Precursor ◽  
Glycogen Deposition

We previously described an isotopic method for quantifying the rate of appearance of hepatic UDP-glucose (Ra UDP-Glc) and the direct entry of glucose into hepatic UDP-Glc in humans. Here, the method is tested in depth in rats. The basic principles are that dilution of labeled galactose in hepatic UDP-Glc, sampled noninvasively by the xenobiotic glucuronate (GlcUA) method, reveals Ra UDP-Glc. First, labeling patterns in secreted acetaminophen-GlcUA were compared with hepatic glycogen and plasma glucose by use of mass isotopomer distribution analysis from [2-(13)C]glycerol. Labeling was consistent with common precursor pools of glucose 6-phosphate and triose-phosphate for all end products studied in fasted and in intravenous glucose- and fructose-infused states. Next, [1-(3)H]galactose was administered. After a 24-h fast, Ra UDP-Glc was 25.0 +/- 1.7 mumol.kg body wt-1.min-1 and rose to 57.7 and 72.7 mumol.kg-1.min-1 at intravenous glucose infusion rates of 111 and 167-194 mumol.kg-1.min-1, respectively. Liver glycogen deposition correlated closely with Ra UDP-Glc (R2 = 0.76), although the turnover value was approximately 50% higher than the net deposition rate. In conclusion, the turnover of an intrahepatic metabolite, UDP-Glc, can be measured noninvasively, and Ra UDP-Glc correlates with liver glycogen deposition in rats.

Adrenal, Hypophyseal and Pancreatic Hormones in the Liver Glycogen Response to Low Atmospheric Pressure

1957 ◽  
Vol 191 (2) ◽  
pp. 342-344
Author(s):  
L. L. Langley ◽  
C. H. Gunthorpe
Keyword(s):  
Atmospheric Pressure ◽  
Liver Glycogen ◽  
Diabetic Rats ◽  
Pancreatic Hormones ◽  
Minimal Dose ◽  
Significant Difference ◽  
Hypophysectomized Rats ◽  
Low Atmospheric Pressure ◽  
Glycogen Deposition ◽  
Adrenalectomized Rats

The administration of 3 cc of adrenocortical extract (Upjohn) to adrenalectomized rats fasted at sea-level fails to cause liver glycogen deposition. Such animals under low atmospheric pressure accumulate about 1% liver glycogen. Adrenalectomized-hypophysectomized rats maintained on a minimal dose of hypophyseal extract, given 3 cc of adrenocortical extract and stressed do not deposit liver glycogen. These results suggest that the hypophyseal hormones function not only to control the adrenal cortices under these conditions, but also may contribute directly to the observed carbohydrate alterations. When larger doses of hypophyseal hormones are used there is a significant difference in liver glycogen between the stressed and nonstressed groups indicating the possible implication of still another agent, perhaps insulin, since alloxan diabetic rats do not accumulate liver glycogen in response to low atmospheric pressure.

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