THE EFFECT OF SOME TRANSPLANTABLE TUMORS ON THE NUCLEIC ACID METABOLISM OF THE HOST TISSUES

1963 ◽  
Vol 41 (11) ◽  
pp. 2237-2247 ◽  
Author(s):  
J. C. Nixon ◽  
S. H. Zbarsky
Keyword(s):  
Nucleic Acid ◽  
Tritiated Thymidine ◽  
Nucleic Acid Metabolism ◽  
Ehrlich Tumor ◽  
Host Liver ◽  
Novikoff Hepatoma ◽  
Transplantable Tumors ◽  
Dose Levels ◽  
Host Tissues

A study was made of the effect of several transplantable tumors on the incorporation in vivo of formate-C14 and tritiated thymidine into the nucleic acids of the host tissues. The presence of the ascitic or subcutaneous forms of the Ehrlich tumor in mice was found to have little effect on the incorporation of formate-C14 into the nucleic acid purines and thymine of the host liver, spleen, kidney, and lung. Experiments with thymidine-H3 were carried out with mice bearing the Erhlich ascites tumor, using three dose levels of the precursor, 0.014, 0.14 and 1.40 μmoles per mouse. At all levels incorporation into liver DNA of the tumor-bearing mice was greater than in controls, whereas the reverse was true for intestinal mucosa, especially at the lowest dosage. With the higher levels of thymidine-H3, incorporation into the DNA of spleen of the tumor animals was higher than in the controls. Variable results were observed for the other tissues examined. The presence of Novikoff hepatoma in rats had little effect on the uptake of tritiated thymidine by the DNA of the host tissues. The presence of the intramuscular form of Walker carcinosarcoma 256 was accompanied by an increased uptake into the DNA of lung and particularly into the DNA of liver and spleen.

THE EFFECT OF SOME TRANSPLANTABLE TUMORS ON THE NUCLEIC ACID METABOLISM OF THE HOST TISSUES

1963 ◽  
Vol 41 (1) ◽  
pp. 2237-2247
Author(s):  
J. C. Nixon ◽  
S. H. Zbarsky
Keyword(s):  
Nucleic Acid ◽  
Tritiated Thymidine ◽  
Nucleic Acid Metabolism ◽  
Ehrlich Tumor ◽  
Host Liver ◽  
Novikoff Hepatoma ◽  
Transplantable Tumors ◽  
Dose Levels ◽  
Host Tissues

A study was made of the effect of several transplantable tumors on the incorporation in vivo of formate-C14 and tritiated thymidine into the nucleic acids of the host tissues. The presence of the ascitic or subcutaneous forms of the Ehrlich tumor in mice was found to have little effect on the incorporation of formate-C14 into the nucleic acid purines and thymine of the host liver, spleen, kidney, and lung. Experiments with thymidine-H3 were carried out with mice bearing the Erhlich ascites tumor, using three dose levels of the precursor, 0.014, 0.14 and 1.40 μmoles per mouse. At all levels incorporation into liver DNA of the tumor-bearing mice was greater than in controls, whereas the reverse was true for intestinal mucosa, especially at the lowest dosage. With the higher levels of thymidine-H3, incorporation into the DNA of spleen of the tumor animals was higher than in the controls. Variable results were observed for the other tissues examined. The presence of Novikoff hepatoma in rats had little effect on the uptake of tritiated thymidine by the DNA of the host tissues. The presence of the intramuscular form of Walker carcinosarcoma 256 was accompanied by an increased uptake into the DNA of lung and particularly into the DNA of liver and spleen.

scholarly journals THE INCORPORATION OF FORMATE-C14 INTO THE NUCLEIC ACIDS OF RATS WITH REGENERATING LIVER AND NOVIKOFF HEPATOMA

1959 ◽  
Vol 37 (1) ◽  
pp. 1405-1416 ◽  
Author(s):  
J. C. Nixon ◽  
S. H. Zbarsky
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Mitotic Activity ◽  
Intestinal Mucosa ◽  
Regenerating Liver ◽  
Simultaneous Presence ◽  
Novikoff Hepatoma ◽  
Mitotic Frequency ◽  
Host Tissues

A study was made of the incorporation in vivo of formate-C14 into the purines and thymine of regenerating liver and Novikoff hepatoma in the rat, during the period of maximum mitotic activity of these tissues. The effects of these tissues on one another and on certain host tissues were also studied. The maximum mitotic frequency of Novikoff hepatoma was observed on the 4th day of growth following transplantation. This tumor caused a decrease in formate incorporation into the nucleic acid purines and thymine of the host's spleen and intestinal mucosa but had little effect on liver. The results also indicated that the uptake of formate by the RNA adenine of spleen and intestinal mucosa and the DNA thymine of intestinal mucosa was diminished by the presence of regenerating liver. The simultaneous presence of both regenerating liver and Novikoff hepatoma generally lowered the incorporation of formate-C14 into the nucleic acids of the host spleen and intestinal mucosa. It was observed further that the utilization of formate by the nucleic acids of Novikoff hepatoma and regenerating rat liver was decreased in animals containing both of these rapidly dividing tissues.

scholarly journals THE INCORPORATION OF FORMATE-C14 INTO THE NUCLEIC ACIDS OF RATS WITH REGENERATING LIVER AND NOVIKOFF HEPATOMA

1959 ◽  
Vol 37 (12) ◽  
pp. 1405-1416 ◽  
Author(s):  
J. C. Nixon ◽  
S. H. Zbarsky
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Mitotic Activity ◽  
Intestinal Mucosa ◽  
Regenerating Liver ◽  
Simultaneous Presence ◽  
Novikoff Hepatoma ◽  
Mitotic Frequency ◽  
Host Tissues

A study was made of the incorporation in vivo of formate-C14 into the purines and thymine of regenerating liver and Novikoff hepatoma in the rat, during the period of maximum mitotic activity of these tissues. The effects of these tissues on one another and on certain host tissues were also studied. The maximum mitotic frequency of Novikoff hepatoma was observed on the 4th day of growth following transplantation. This tumor caused a decrease in formate incorporation into the nucleic acid purines and thymine of the host's spleen and intestinal mucosa but had little effect on liver. The results also indicated that the uptake of formate by the RNA adenine of spleen and intestinal mucosa and the DNA thymine of intestinal mucosa was diminished by the presence of regenerating liver. The simultaneous presence of both regenerating liver and Novikoff hepatoma generally lowered the incorporation of formate-C14 into the nucleic acids of the host spleen and intestinal mucosa. It was observed further that the utilization of formate by the nucleic acids of Novikoff hepatoma and regenerating rat liver was decreased in animals containing both of these rapidly dividing tissues.

scholarly journals Abnormal Nucleic Acid Metabolism of Lymphocytes in Plasma Cell Myeloma and Macroglobulinemia

Blood ◽  
1969 ◽  
Vol 33 (2) ◽  
pp. 300-312 ◽  
Author(s):  
SYDNEY E. SALMON ◽  
H. HUGH FUDENBERG
Keyword(s):  
Nucleic Acid ◽  
Dna Synthesis ◽  
Past History ◽  
Acid Synthesis ◽  
Nucleic Acid Metabolism ◽  
Lymphocyte Function ◽  
Dna And Rna ◽  
Lymphocyte Dna Synthesis

Abstract Twenty-six patients with multiple myeloma and macroglobulinemia of Waldenström were studied clinically and immunologically with characterization of their paraproteins and normal immunoglobulins, as well as by in vitro culture of their peripheral lymphocytes for evaluation of DNA and RNA synthesis after phytohemagglutinin stimulation. The lymphocytes of the patients were found to be significantly deficient in response to PHA as compared to normals and patients with benign hypergammaglobulinemia. Levels of normal immunoglobulins were reduced in almost all of the paraproteinemic patients, but there was not a direct correlation between lymphocyte unresponsiveness and immunoglobulin deficiency. The defect in lymphocyte function appeared to be cellular inasmuch as normal lymphocytes had normal DNA synthesis when cultured in myeloma plasma. The decrease in lymphocyte nucleic acid synthesis appeared to be unrelated to immunoglobulin class, quantitative levels or antigenic characteristics of the patients’ paraproteins. Untreated myeloma patients with a past history of infection had lower levels of lymphocyte DNA synthesis than those patients who lacked such a history, suggesting a relationship between the in vitro lymphocyte response to PHA and the in vivo response to the antigenic challenge of bacterial infection.

EFFECT OF L-CYSTEINE ON α-AMYLASE PRODUCTION AND NUCLEIC ACID METABOLISM IN BACILLUS SUBTILIS

1963 ◽  
Vol 9 (3) ◽  
pp. 337-341 ◽  
Author(s):  
MICHIO OISHI ◽  
SHIGERU KITAYAMA ◽  
HAJIME TAKAHASHI ◽  
BUNJI MARUO
Keyword(s):  
Bacillus Subtilis ◽  
Nucleic Acid ◽  
Acid Metabolism ◽  
Nucleic Acid Metabolism ◽  
Amylase Production

A GATA3 Targeting Nucleic Acid Nanocapsule for In Vivo Gene Regulation in Asthma

ACS Nano ◽  
2021 ◽  
Author(s):  
Tyler D. Gavitt ◽  
Alyssa K. Hartmann ◽  
Shraddha S. Sawant ◽  
Arlind B. Mara ◽  
Steven M. Szczepanek ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Nucleic Acid
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