SOME EFFECTS OF DIETARY THIOURACIL AND DIETARY IODINE SUPPLEMENTATION ON THE RESPONSES OF THE IMMATURE PULLET TO ESTROGEN
Sexually immature pullets were given 1.5 mg estradiol benzoate by intramuscular injection on alternate days over a 14-day period. The resultant increase of oviduct weight was enhanced by 70% when 1% thiouracil was included in the diet over the period of the injections. Supplementation of the diet with 1.0 mg iodine per lb did not modify this effect of dietary thiouracil on the response of oviduct to estrogen. Consideration of this result in conjunction with previous results shows that a necessary condition for this positive effect of thiouracil on response of the oviduct to estrogen is administration of the estrogen on alternate days.The following effects of thiouracil on the estrogenized pullets also attained statistical significance: decrease of estrogen-induced hypercalcemia; increase of ovary weight, liver weight, and total liver crude protein and fat; increase of kidney weight and percentage dry matter in kidney.The iodine supplement increased ovary weight significantly in the unestrogenized pullets but not in the estrogenized pullets. The iodine supplement also tended to increase total liver crude protein in the estrogenized pullets but not in the unestrogenized pullets.