ON THE ANTI-INFLAMMATORY ACTION OF AMINOACETONITRILE (AAN)

1957 ◽  
Vol 35 (11) ◽  
pp. 1029-1031 ◽  
Author(s):  
Hans Selye
Keyword(s):  
Inherent Property ◽  
Inflammatory Exudate ◽  
Small Doses ◽  
Anti Inflammatory ◽  
Desoxycorticosterone Acetate ◽  
Inflammatory Action ◽  
Adrenalectomized Rats

Experiments on adrenalectomized rats maintained on small doses of cortisol acetate and desoxycorticosterone acetate indicate that aminoacetonitrile markedly inhibits the production of inflammatory exudate in the "granuloma pouch" test. It is concluded that this antiphlogistic effect is an inherent property of the lathyrogenic aminonitrile and not merely the consequence of an adrenal-mediated stressor action.

ON THE ANTI-INFLAMMATORY ACTION OF AMINOACETONITRILE (AAN)

1957 ◽  
Vol 35 (1) ◽  
pp. 1029-1031
Author(s):  
Hans Selye
Keyword(s):  
Inherent Property ◽  
Inflammatory Exudate ◽  
Small Doses ◽  
Anti Inflammatory ◽  
Desoxycorticosterone Acetate ◽  
Inflammatory Action ◽  
Adrenalectomized Rats

Experiments on adrenalectomized rats maintained on small doses of cortisol acetate and desoxycorticosterone acetate indicate that aminoacetonitrile markedly inhibits the production of inflammatory exudate in the "granuloma pouch" test. It is concluded that this antiphlogistic effect is an inherent property of the lathyrogenic aminonitrile and not merely the consequence of an adrenal-mediated stressor action.

Chronopharmacological studies of phenylbutazone in the rat

1983 ◽  
Vol 61 (6) ◽  
pp. 649-652 ◽  
Author(s):  
G. Labrecquf ◽  
P. M. Bélanger ◽  
F. M. Doré
Keyword(s):  
Lethal Dose ◽  
Circadian Variation ◽  
Temporal Variations ◽  
Paw Edema ◽  
Lethal Effects ◽  
Ulcerogenic Effect ◽  
Small Doses ◽  
The Mean ◽  
Anti Inflammatory ◽  
Inflammatory Action

Temporal variations in the anti-inflammatory action and in the ulcerogenic and lethal effects of phenylbutazone were studied in rats. The results indicate that small doses of the drug produced a larger reduction of paw edema in the morning than in the evening. At 0900, doses of 10, 30, and 100 mg/kg of phenylbutazone reduced the carrageenan-induced paw edema by 23, 44, and 66%, respectively. At 2000, the same doses of the drug decreased the paw edema by 9, 22, and 62%, respectively. No circadian variation was observed in the ulcerogenic effect of phenylbutazone. The mean lethal dose (LD50) of the drug was larger in the morning than in the evening and the values obtained were 710 ± 24 (SE) mg/kg at 0900 in comparison to 525 ± 38 (SE) mg/kg at 2000.

THE EFFECTS OF SOME ANTI-INFLAMMATORY SUBSTANCES ON CARRAGEENIN-INDUCED GRANULOMATA

1962 ◽  
Vol 25 (1) ◽  
pp. 87-93 ◽  
Author(s):  
R. M. ATKINSON ◽  
LESLEY JENKINS ◽  
E. G. TOMICH ◽  
E. A. WOOLLETT
Keyword(s):  
Testosterone Propionate ◽  
Relative Activity ◽  
Subcutaneous Injections ◽  
Wet Weight ◽  
Anti Inflammatory ◽  
Desoxycorticosterone Acetate ◽  
Oral Doses ◽  
Adrenalectomized Rats

SUMMARY Carrageenin pellets, implanted subcutaneously in adrenalectomized rats, produced in 5 days compact, easily dissected granulomata. Accepted anti-inflammatory steroids administered as single daily subcutaneous injections or in the diet, but not as single daily oral doses, reduced the granuloma wet weight. The relative anti-inflammatory activities of cortisol, prednisolone and betamethasone, administered subcutaneously or in the diet, duplicated their relative clinical values. The relative activity of dexamethasone to cortisol was three times that reported on patients. Corticosterone acetate was weakly active in this test, desoxycorticosterone acetate increased granuloma weight, and oestrone, mepyramine maleate, mersalyl, progesterone, norethandrolone, testosterone propionate and Pitressin were inactive.

Antiphlogistic action of granuloma pouch exudates in intact or adrenalectomized rats

1963 ◽  
Vol 205 (6) ◽  
pp. 1080-1082 ◽  
Author(s):  
G. DiPasquale ◽  
R. J. Girerd ◽  
V. L. Beach ◽  
B. G. Steinetz
Keyword(s):  
Body Weight Gain ◽  
Systemic Circulation ◽  
Mechanisms Of Action ◽  
Concomitant Treatment ◽  
Cotton Pellet ◽  
Small Doses ◽  
Hypophysectomized Rats ◽  
Anti Inflammatory ◽  
Antiphlogistic Activity ◽  
Adrenalectomized Rats

Injection of lyophilized granuloma pouch exudate inhibited the formation of cotton pellet granulomas in rats. In contrast, lyophilized serum, obtained from rats bearing granuloma pouches, did not exert measurable anti-inflammatory effects. The antiphlogistic activity was not dependent upon the time of pouch development at which the exudates were harvested, and thus did not appear to be derived from the systemic circulation. Unlike ACTH, the exudates failed to elevate plasma-corticosteroid levels in hypophysectomized rats. The exudates exerted significant anti-inflammatory activity in adrenalectomized rats, and these effects were enhanced by concomitant treatment with small doses of whole adrenocortical extract (ACE). The exudates themselves contained little or no corticosterone or cortisol. Thus, the anti-inflammatory properties of pouch exudates do not appear to depend upon contained ACTH or adrenalcorticoids. In contrast to glucocorticoids, anti-inflammatory doses of exudate had no adverse effect on body weight gain. This fact, together with the observed synergism of exudate and ACE in reducing inflammation, suggests that the mechanisms of action of exudate and glucocorticoids may be different.

Bioguided determination of the anti-inflammatory action of STW 5 and STW 6

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
K Nieber ◽  
S Michael ◽  
K Grötzinger ◽  
JW Rauwald ◽  
SN Okpanyi ◽  
...  
Keyword(s):  
Anti Inflammatory ◽  
Inflammatory Action

PITUITARY AND BLOOD CORTICOTROPHIN CHANGES IN ADRENALECTOMIZED RATS MAINTAINED ON PHYSIOLOGICAL DOSES OF CORTICOSTEROIDS

1962 ◽  
Vol 39 (1) ◽  
pp. 79-86 ◽  
Author(s):  
J. R. Hodges ◽  
Joan Vernikos-Danellis
Keyword(s):  
Ascorbic Acid ◽  
Pituitary Gland ◽  
Replacement Therapy ◽  
Daily Treatment ◽  
Mild Stress ◽  
Acid Control ◽  
Small Doses ◽  
Response To Stress ◽  
Adrenalectomized Rats

ABSTRACT Pituitary and blood corticotrophin (ACTH) concentrations were estimated in adrenalectomized rats maintained on cortisol or crude adrenocortical extract (ACE) with and without ascorbic acid. Blood ACTH levels were also determined in similarly treated animals after subjection to mild stress. Thirty days after adrenalectomy there were marked rises in pituitary and blood corticotrophin concentration which were prevented by daily treatment with small doses of cortisol or ACE. In contrast to intact animals, adrenalectomized rats exhibited markedly increased adrenocorticotrophic responses to mild stress. This pituitary hyperexcitability was not diminished by replacement therapy with corticoids alone but was considerably reduced by ascorbic acid given in conjunction with ACE. It is suggested that corticoids control the rate at which ACTH is synthesised in the pituitary gland and that other factors, including ascorbic acid, control the excitability of the pituitary gland in its adrenocorticotrophic response to stress.

Evaluation of anti-pyretic activity of Dracaena sanderiana by Brewer’s yeast method

2020 ◽  
Vol 9 (2) ◽  
pp. 32-34
Author(s):  
Pavani C H
Keyword(s):  
Herbal Remedies ◽  
Standard Drug ◽  
Chemical Substances ◽  
Beneficial Effects ◽  
Potential Value ◽  
Plant Effects ◽  
Therapeutic Properties ◽  
Dracaena Sanderiana ◽  
Anti Inflammatory ◽  
Inflammatory Action

These medicinal plants are used to develop a therapy for the disease. To improve the science, investigate the scientific proof and activities validation, therefore the use of various herbal remedies for their pain-relieving and anti-inflammatory action in these current days. includes influence, anti-inflammatory, anti effect, analgesia, effects and some beneficial effects on the GI system. show the potential value of pain relief, cancer prevention and weight loss. According to these plant effects, consider that this present study was mainly based on to investigate and likely to reduce the fever caused by the outdoor and indoor. potential of is evidenced in leave studies. The medicinal plant produces a variety of chemical substances which shows significant therapeutic properties with the standard drug paracetamol.

Pentoxifylline and Oxypurinol: Potential Drugs to Prevent the “Cytokine Release (Storm) Syndrome” Caused by SARS-CoV-2?

2020 ◽  
Vol 26 (35) ◽  
pp. 4515-4521
Author(s):  
Francisco J. López-Iranzo ◽  
Ana M. López-Rodas ◽  
Luis Franco ◽  
Gerardo López-Rodas
Keyword(s):  
Lung Parenchyma ◽  
Interstitial Tissue ◽  
Cytokine Release ◽  
Phase I Clinical Trials ◽  
Infected People ◽  
Tnf Α ◽  
Transient Loss ◽  
Anti Inflammatory ◽  
And Control ◽  
Inflammatory Action

Background: COVID-19, caused by SARS-CoV-2, is a potentially lethal, rapidly-expanding pandemic and many efforts are being carried out worldwide to understand and control the disease. COVID-19 patients may display a cytokine release syndrome, which causes severe lung inflammation, leading, in many instances, to death. Objective: This paper is intended to explore the possibilities of controlling the COVID-19-associated hyperinflammation by using licensed drugs with anti-inflammatory effects. Hypothesis: We have previously described that pentoxifylline alone, or in combination with oxypurinol, reduces the systemic inflammation caused by experimentally-induced pancreatitis in rats. Pentoxifylline is an inhibitor of TNF-α production and oxypurinol inhibits xanthine oxidase. TNF-α, in turn, activates other inflammatory genes such as Nos2, Icam or IL-6, which regulate migration and infiltration of neutrophils into the pulmonary interstitial tissue, causing injury to the lung parenchyma. In acute pancreatitis, the anti-inflammatory action of pentoxifylline seems to be mediated by the prevention of the rapid and presumably transient loss of PP2A activity. This may also occur in the hyperinflammatory -cytokine releasing phase- of SARS-CoV-2 infection. Therefore, it may be hypothesized that early treatment of COVID-19 patients with pentoxifylline, alone or in combination with oxypurinol, would prevent the potentially lethal acute respiratory distress syndrome. Conclusion: Pentoxifylline and oxypurinol are licensed drugs used for diseases other than COVID-19 and, therefore, phase I clinical trials would not be necessary for the administration to SARS-CoV-2- infected people. It would be worth investigating their potential effects against the hyperinflammatory response to SARS-CoV-2 infection.

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