Reversal of fungitoxicity of 8-quinolinols and their copper (II) bischelates. I. Amino acids and related compounds

1975 ◽  
Vol 21 (3) ◽  
pp. 409-411 ◽  
Author(s):  
Herman Gershon ◽  
Raulo Parmegiani ◽  
Janice Baricko Hauck
Keyword(s):  
Amino Acids ◽  
Aspergillus Oryzae ◽  
Inhibitory Action ◽  
Related Compounds

The effect of amino acids and related compounds on the toxicity of 8-quinolinols and their copper(II) bischelates to Aspergillus oryzae (ATCC 1011) was studied. None of the compounds tested except the thiol-containing compounds cysteine, cysteamine, glutathione, and N-acetylcysteine reversed the inhibitory action of 8-quinolinol but not that of 5-iodo-8-quinolinol or bis(8-quinolinolato)copper(II). It appears that the mechanism(s) of fungitoxicity of 8-quinolinol is different from that of 5-iodo-8-quinolinol or bis(8-quinolinolato)copper(II).

Reversal of fungitoxicity of 8-quinolinols and their copper(II) bischelates. II. Reversal of the action of 8-quinolinol by DL-α-lipoic acid

1981 ◽  
Vol 27 (6) ◽  
pp. 612-615 ◽  
Author(s):  
Herman Gershon ◽  
Larry Shanks
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Aspergillus Oryzae ◽  
Lipoic Acid ◽  
Krebs Cycle ◽  
Acid Biosynthesis ◽  
Amino Acids And Derivatives ◽  
Related Compounds

The effect of amino acids and derivatives, Krebs cycle acids and related compounds, fatty acids, and vitamins and related compounds on the toxicity of 8-quinolinol and bis(8-quinolinolato)copper(II) to Aspergillus oryzae (ATCC 1011) was studied. Only aliphatic thiol-containing compounds (cysteine, glutathione, dithioerythritol, and dithiothreitol) and DL-α-lipoic acid protected against 8-quinolinol but not its copper(II) bischelate.It is suggested that 8-quinolinol inhibits lipoic acid biosynthesis, and the mode of fungitoxicity of 8-quinolinol is different from that of bis(8-quinolinolato)copper(II).

scholarly journals 181 Effects of Aspergillus oryzae prebiotic on energy and nutrient digestibility of growing pigs

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 80-80
Author(s):  
Jinlong Zhu ◽  
Gerald C Shurson ◽  
Lynsey Whitacre ◽  
Ignacio R Ipharraguerre ◽  
Pedro E Urriola
Keyword(s):  
Amino Acids ◽  
Aspergillus Oryzae ◽  
Nutrient Content ◽  
Nutrient Digestibility ◽  
Growing Pigs ◽  
Adaptation Period ◽  
Ileal Digestibility ◽  
High Fiber ◽  
Wheat Middlings ◽  
Corn Distillers

Abstract The objective of this study was to determine the effects of an Aspergillus oryzae prebiotic (AOP, Amaferm®) on nutrient digestibility in growing pigs fed high fiber diets. Eighteen growing barrows (initial BW = 50.60 ± 4.90 kg) were surgically equipped with a T-cannula at the distal ileum. Three diets were formulated by including 29.65% corn-distillers dried grains with solubles (DDGS), 36.65% rice bran (RB) or 24.59% wheat middlings (WM) in corn and soybean meal-based diets to meet nutrient requirements for 50 to 75 kg growing pigs. Three additional diets were formulated by supplementing 0.05% AOP at the expense of corn in DDGS (DDGS + AOP), RB (RB + AOP), and wheat middlings (WM + AOP) diets. Pigs were allotted randomly to a triplicated 6 × 2 Youden square design with 6 diets and 2 successive periods. Feces and ileal digesta were collected for 2 d after a 21 d adaptation period, and nutrient content was analyzed to calculate apparent total tract digestibility (ATTD) and apparent ileal digestibility (AID). Standardized ileal digestibility (SID) of amino acids was calculated by correcting AID with basal endogenous amino acid losses determined from the same set of pigs. Supplementation of 0.05% AOP increased (P < 0.05) ATTD of DM, GE, CP, NDF, and ash in DDGS, RB, and WM diets. Diet DE was 35 kcal/kg greater (P < 0.05) in pigs fed AOP supplemented diets compared with those fed diets without AOP. Pigs fed DDGS+AOP diet had greater (P < 0.05) AID of ether extract compared to those fed DDGS diet. However, supplementation of AOP did not (P > 0.05) affect AID of GE, DM, CP, NDF, ash or SID of amino acids. In conclusion, supplementation of AOP in high fiber diets containing DDGS, RB, or WM increased total tract energy value and nutrient digestibility.

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