A substance enhancing virus growth and antagonistic to interferon action

1968 ◽  
Vol 14 (9) ◽  
pp. 965-969 ◽  
Author(s):  
Edward T. Sheaff ◽  
Robert B. Stewart
Keyword(s):  
Chick Embryo ◽  
Cell Line ◽  
Cell Cultures ◽  
Sindbis Virus ◽  
Embryo Cell ◽  
Virus Growth ◽  
Chick Embryo Cell ◽  
Similar Substance

An interferon antagonist was obtained free of both cells and virus from a hamster cell line (BHK-21) infected with Sindbis virus. This material was also found to enhance Sindbis virus growth. A method for the assay of the interferon antagonist is described which is based on its capacity to reduce the activity of interferon as measured by a lack of reduction in Sindbis virus plaque numbers. The antagonist was found to be resistant to ribonuclease and deoxyribonuclease but sensitive to trypsin. Evidence for the existence of a similar substance in Sindbis virus infected chick embryo cell cultures was also obtained.

Effect of interferon on Sindbis virus growth in chick-embryo cell cultures

1969 ◽  
Vol 15 (6) ◽  
pp. 605-610 ◽  
Author(s):  
Robert B. Stewart ◽  
Edward T. Sheaff
Keyword(s):  
Chick Embryo ◽  
Cell Cultures ◽  
Sindbis Virus ◽  
Embryo Cell ◽  
Virus Growth ◽  
Chick Embryo Cell ◽  
Embryo Cells ◽  
Number Of Cells

A study of the effect of interferon on the growth of Sindbis virus in cultures of chick-embryo cells has shown that interferon forms an association with cells (uptake) and that the action of interferon is concentration rather than amount dependent. Evidence has also been obtained that interferon acts to reduce the yield of virus from cells, but does not reduce the number of cells synthesizing virus (all or none effect).

Controlled release of particle-associated RNA-dependent DNA polymerase by primary chick embryo cell cultures

1978 ◽  
Vol 117 (2) ◽  
pp. 383-392 ◽  
Author(s):  
Georg Bauer ◽  
Robert R. Friis ◽  
Hans Mattersberger ◽  
Peter Hans Hofschneider
Keyword(s):  
Controlled Release ◽  
Chick Embryo ◽  
Dna Polymerase ◽  
Cell Cultures ◽  
Embryo Cell ◽  
Chick Embryo Cell

Transmission of Sindbis Virus by Aedes aegypti to a Chick Embryo Cell Culture System.

1965 ◽  
Vol 118 (3) ◽  
pp. 736-741 ◽  
Author(s):  
J. O. Mason ◽  
T. E. Frothingham ◽  
A. Spielman ◽  
T. H. Weller
Keyword(s):  
Cell Culture ◽  
Chick Embryo ◽  
Aedes Aegypti ◽  
Culture System ◽  
Sindbis Virus ◽  
Embryo Cell ◽  
Cell Culture System ◽  
Chick Embryo Cell
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