Rigid framing connections for tubular columns

1977 ◽  
Vol 4 (2) ◽  
pp. 134-144 ◽  
Author(s):  
Y.-M. Giroux ◽  
A. Picard
Keyword(s):  
Brittle Fracture ◽  
Inelastic Deformation ◽  
Present Report ◽  
Design Procedure ◽  
Experimental Program ◽  
Tubular Columns ◽  
First Case ◽  
Flange Beams ◽  
Rigid Joints ◽  
Hollow Structural Sections

This paper presents the design and development of rigid framing connections between wide flange beams and tubular columns for the case where the beam flange is substantially narrower than the column face. The present report is a sequel to a previous paper dealing with a connection in which the beam flange and the column face are of equal width.In the connection proposed here the transfer of flange stress from the beam to the sides of the column is effected by means of coped strap angles while transfer of shear to the column face is done through welded double angles.The experimental program comprised 15 specimens, including 2 standard rigid joints introduced to give a comparison basis for the [Formula: see text] (moment–rotation) curves.The results indicate that, in the case of a beam flange narrower than the column face, both special attention to the geometrical design of the strap angles and provision of a web connection (not required in the first case) are necessary to ensure that brittle fracture will not take place in the strap angles. A connection is then obtained which can develop the plastic moment MP and sustain appreciable inelastic deformation and is therefore suitable for plastically-designed frames.The rigidity of the connection, slightly less than that of a standard joint to a wide flange column, makes it a 'nearly rigid' connection.Exploratory analysis of the effect of that relative loss of rigidity on the sway behaviour of multi-story frames shows that, while this influence should not be critical for frames of the height that would normally be possible with the currently-available hollow structural sections, it may be significant enough to warrant investigation of P-Δ effects.A design procedure is proposed in the Appendix.

Moment connections between wide flange beams and square tubular columns

1976 ◽  
Vol 3 (2) ◽  
pp. 174-185 ◽  
Author(s):  
A. Picard ◽  
Y.-M. Giroux
Keyword(s):  
Brittle Fracture ◽  
Inelastic Deformation ◽  
Design Method ◽  
Theoretical Studies ◽  
Moment Connections ◽  
Testing Program ◽  
Tubular Columns ◽  
Rigid Frames ◽  
Flange Beams ◽  
Rigid Joints

This paper presents the design and development of moment connections between wide flange beams and square tubular columns in rigid frames. The connection is effected by means of coped strap angles used to transfer stress from the beam flanges to the sides of the column. The testing program comprised 23 specimens, including two standard rigid joints introduced to give a comparison basis for the [Formula: see text] curves.The results indicate that after adequate precautions have been taken to prevent the occurrence of brittle fracture in the strap angles a connection is obtained which can develop MP and sustain appreciable inelastic deformation, making it suitable for plastically designed frames. The rigidity of the connection is less than that of a standard connection but high enough for the joint to be termed 'nearly rigid'. Preliminary theoretical studies indicate that the effect of the relative loss of rigidity on the sway behaviour of multistory frames may be significant and that P-Δ effects should be investigated.All joints considered here comprised beams of flange width equal to that of a column face.A design method is proposed in the Appendix.

CUBITAL TUNNEL SYNDROME DUE TO GIANT CELL TUMOUR OF TENDON SHEATHS

Hand Surgery ◽  
2006 ◽  
Vol 11 (01n02) ◽  
pp. 89-91 ◽  
Author(s):  
G. Mitsionis ◽  
E. E. Pakos ◽  
I. Gavriilidis ◽  
Anna Batistatou
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
Present Report ◽  
Cubital Tunnel Syndrome ◽  
Cell Tumour ◽  
Cubital Tunnel ◽  
Malignant Neoplasms ◽  
Entrapment Neuropathies ◽  
First Case ◽  
Tunnel Syndrome

Cubital tunnel syndrome is one of the most common entrapment neuropathies in adults. It is mainly caused by the depression of ulnar nerve from normal structures at the elbow area. Despite the fact that several pathgological entities can be potential mechanisms of the syndrome, the pathogenesis due to benign or malignant neoplasms is extremely rare. In the present report we describe the first case of cubital tunnel syndrome due to giant cell tumour of the tendon sheaths.

scholarly journals Epileptic Seizures Induced by a Spontaneous Carotid Cavernous Fistula

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Güner Koyuncu Çelik ◽  
Erkan Yildirim
Keyword(s):  
Present Report ◽  
Epileptic Seizures ◽  
Digital Subtraction ◽  
Resonance Imaging ◽  
Carotid Cavernous Fistula ◽  
Cavernous Fistula ◽  
The Past ◽  
First Case ◽  
Eye Symptoms ◽  
Magnetic Resonance Imaging Mri

A 79-year-old woman was admitted to our emergency department with complaints of fainting and loss of consciousness three times during the past month. She was diagnosed with epilepsy and started to be treated with antiepileptic drug. Physical examination showed, in the left eye, chemosis, limited eye movements in all directions, and minimal exophthalmos as unexisting symptoms on admission developed on the sixth day. Orbital magnetic resonance imaging (MRI) and digital subtraction angiography (DSA) imaging revealed a carotid cavernous fistula (CCF). Epileptic attacks and ophthalmic findings previously present but diagnosed during our examinations were determined to ameliorate completely after performing the coil embolization. Based on literature, we present the first case with nontraumatic CCF manifesting with epileptic seizures and intermittent eye symptoms in the present report.

scholarly journals AcanthamoebaSpecies Keratitis in a Soft Contact Lens Wearer Molecularly Linked to Well Water

2006 ◽  
Vol 17 (2) ◽  
pp. 120-122 ◽  
Author(s):  
Samira Mubareka ◽  
Michelle Alfa ◽  
Godfrey K Harding ◽  
Gregory Booton ◽  
Marilyn Ekins ◽  
...  
Keyword(s):  
Contact Lens ◽  
Present Report ◽  
Well Water ◽  
Soft Contact ◽  
Contact Lens Wearer ◽  
Contact Lens Wear ◽  
Soft Contact Lens ◽  
First Case ◽  
Primary Care Practitioners ◽  
High Degree

Acanthamoebaspecies keratitis has been associated with soft contact lens wear. In the present report, an epidemiological link was established between the patient's isolate and well water from the home using molecular methods. To the authors' knowledge, this is the first case in Canada where such a link has been established. Primary care practitioners and specialists, including ophthalmologists and infectious diseases specialists, must maintain a high degree of clinical suspicion in soft contact lens wearers with keratitis unresponsive to conventional topical and systemic treatment.

BEHAVIOR OF EXPANSIVE CONCRETE-FILLED STEEL TUBULAR COLUMNS UNDER AXIAL LOADINGS

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Aman Mwafy ◽  
Ame El-Dieb ◽  
Abdulaziz Lazkani
Keyword(s):  
Load Capacity ◽  
Steel Tube ◽  
Experimental Program ◽  
Outer Diameter ◽  
Test Results ◽  
Limited Information ◽  
Tubular Columns ◽  
Expansive Concrete ◽  
Axial Load Capacity ◽  
Concrete Filled Steel Tubes

Concrete-filled steel tubes (CFSTs) have been introduced to expedite construction and increase the confinement of concrete by the steel tube. While changing the confinement level through the use of expansive additives (EAs) will have an impact on the performance of CFSTs, limited information is available on the behavior of expansive concrete-filled steel tubular (ECFST) columns. The objective of this study is thus twofold: (i) to experimentally assess the behavior of axially loaded ECFSTs, and (ii) to investigate the correlation between the test results and those obtained from prediction approaches. The experimental program of this study consists of testing four 1500 mm CFST/ECFST columns with 153.6 mm outer diameter and 3 mm thickness. The ECFST specimens are divided into two subgroups with 0% and 12% EA dosage and two concrete mixtures, 16 and 37 MPa. The results indicate that the latter is the most promising mixture since it results in a significant enhancement of 64% in the axial load capacity of ECFST columns compare with CFSTs. The study also recommends employing specific confined concrete models with the existing code prediction approaches to arrive at the best correlation with test results.

The Rate (Time)-Dependent Mechanical Behavior of the PMR-15 Thermoset Polymer at 316°C: Experiments and Modeling

2010 ◽  
Vol 132 (4) ◽  
Author(s):  
M. B. Ruggles-Wrenn ◽  
O. Ozmen
Keyword(s):  
Experimental Data ◽  
Strain Rate ◽  
Deformation Behavior ◽  
Inelastic Deformation ◽  
Rate Sensitivity ◽  
Experimental Program ◽  
Strain Rates ◽  
Neat Resin ◽  
Strain Behavior ◽  
Thermoset Polymer

The inelastic deformation behavior of PMR-15 neat resin, a high-temperature thermoset polymer, was investigated at 316°C. The experimental program was designed to explore the influence of strain rate on tensile loading, unloading, and strain recovery behaviors. In addition, the effect of the prior strain rate on the relaxation response of the material, as well as on the creep behavior following strain-controlled loading were examined. Positive, nonlinear strain rate sensitivity is observed in monotonic loading. The material exhibits nonlinear, “curved” stress-strain behavior during unloading at all strain rates. The recovery of strain at zero stress is strongly influenced by the prior strain rate. The prior strain rate also has a profound effect on relaxation behavior. Likewise, creep response is significantly influenced by the prior strain rate. The experimental data are modeled with the viscoplasticity theory based on overstress (VBO). The comparison with experimental data demonstrates that the VBO successfully predicts the inelastic deformation behavior of the PMR-15 polymer under various test histories at 316°C.

Reflections on Mechanisms Affecting the Behavior of FRP-Concrete-Steel Double-Skin Tubular Columns

2016 ◽  
Vol 705 ◽  
pp. 323-331 ◽  
Author(s):  
Togay Ozbakkaloglu
Keyword(s):  
Complex System ◽  
Detailed Examination ◽  
Steel Tube ◽  
Experimental Program ◽  
System Behavior ◽  
Compressive Behavior ◽  
Tubular Columns ◽  
Double Skin ◽  
Concrete Filling ◽  
The University

This paper presents the results of 20 hollow and concrete-filled double-skin tubular columns (DSTCs), which were tested as part of a comprehensive experimental program that was undertaken at The University of Adelaide on FRP-concrete steel DSTCs. The paper is aimed at providing important insights into the influence of two key parameters, namely the diameter of inner steel tube and presence/absence of a concrete-filling inside the inner steel tube, which play major roles in the column behavior through their influences on a series of interacting mechanisms that govern the complex system behavior. A detailed examination of the results yielded a number of important insights into the mechanisms that influence the compressive behavior of DSTCs.

scholarly journals QSAR-Based Computational Approaches to Accelerate the Discovery of Sigma-2 Receptor (S2R) Ligands as Therapeutic Drugs

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5270
Author(s):  
Yangxi Yu ◽  
Hiep Dong ◽  
Youyi Peng ◽  
William J. Welsh
Keyword(s):  
Binding Affinity ◽  
Model Building ◽  
Present Report ◽  
Antidepressant Drug ◽  
Biological Evaluation ◽  
Qsar Modeling ◽  
Therapeutic Drugs ◽  
First Case ◽  
Qsar Models ◽  
Approved Drugs

S2R overexpression is associated with various forms of cancer as well as both neuropsychiatric disorders (e.g., schizophrenia) and neurodegenerative diseases (Alzheimer’s disease: AD). In the present study, three ligand-based methods (QSAR modeling, pharmacophore mapping, and shape-based screening) were implemented to select putative S2R ligands from the DrugBank library comprising 2000+ entries. Four separate optimization algorithms (i.e., stepwise regression, Lasso, genetic algorithm (GA), and a customized extension of GA called GreedGene) were adapted to select descriptors for the QSAR models. The subsequent biological evaluation of selected compounds revealed that three FDA-approved drugs for unrelated therapeutic indications exhibited sub-1 uM binding affinity for S2R. In particular, the antidepressant drug nefazodone elicited a S2R binding affinity Ki = 140 nM. A total of 159 unique S2R ligands were retrieved from 16 publications for model building, validation, and testing. To our best knowledge, the present report represents the first case to develop comprehensive QSAR models sourced by pooling and curating a large assemblage of structurally diverse S2R ligands, which should prove useful for identifying new drug leads and predicting their S2R binding affinity prior to the resource-demanding tasks of chemical synthesis and biological evaluation.

scholarly journals Long-term management of canine disseminated granulomatous meningoencephalitis with imatinib mesylate: a case report

2019 ◽  
Vol 64 (No. 02) ◽  
pp. 92-99
Author(s):  
JH Song ◽  
TS Hwang ◽  
HC Lee ◽  
DH Yu ◽  
BJ Seung ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tyrosine Kinase ◽  
Imatinib Mesylate ◽  
Tyrosine Kinases ◽  
Histopathological Examination ◽  
Present Report ◽  
Clinical Signs ◽  
Resonance Imaging ◽  
First Case

A seven-year-old Toy Poodle was presented for progressive ataxia and seizure episodes. Magnetic resonance imaging revealed inflammatory lesions in the cerebrum and brainstem. Management with imatinib mesylate, prednisolone and hydroxyurea were initiated and resulted in complete resolution of the clinical signs. In regular magnetic resonance imaging scans, the overall appearance of the lesions deteriorated but improved again after an increase in the imatinib mesylate dose. The patient had not shown any neurological signs until death and survived for 1052 days after initial presentation. On histopathological examination, the patient was diagnosed with disseminated granulomatous meningoencephalitis involving the cerebrum and brainstem. Immunohistochemical staining was performed on the five types of tyrosine kinase (PDGFR-α, PDGFR-ß, VEGFR-2, c-Kit and c-Abl proteins), which constitute therapeutic targets for conventional multitargeted tyrosine kinase inhibitors. The immunohistochemical analysis revealed that all these tyrosine kinases were expressed in the brain samples. The present report describes the first case of the use of imatinib mesylate therapy for granulomatous meningoencephalitis in the dog. Therapy with imatinib mesylate plus glucocorticoids appears promising as a new therapeutic intervention in meningoencephalitis of unknown aetiology.

Recurrent Acute Pancreatitis in Pregnancy Caused by Parathyroid Hyperplasia: A Case Report and Literature Review

2020 ◽  
Vol 103 (9) ◽  
pp. 952-959
Keyword(s):  
Acute Pancreatitis ◽  
Case Report ◽  
Primary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Epigastric Pain ◽  
Present Report ◽  
Parathyroid Hyperplasia ◽  
Pathological Examination ◽  
Recurrent Acute Pancreatitis ◽  
First Case

Background: Hypercalcemia during pregnancy leads to multiple maternal and fetal complications. To date, fewer than 30 cases of primary hyperparathyroidism (PHPT)-induced pancreatitis have been diagnosed during pregnancy. Most cases have been caused by a parathyroid adenoma. In the present report, the author described the first case of PHPT due to parathyroid hyperplasia presented with recurrent, acute pancreatitis during pregnancy. Case Report: A 38-year-old female, with a history of acute pancreatitis during her first pregnancy, presented with severe epigastric pain, nausea, and vomiting for three days at 24 weeks of gestation. Parathyroid-dependent, hypercalcemia-induced recurrence of pancreatitis was diagnosed based on the clinical presentation and laboratory investigations. An ultrasound on her neck revealed a possible parathyroid adenoma located on the inferior pole of the left thyroid gland. She underwent an uneventful left-lower parathyroidectomy. The pathological examination revealed parathyroid hyperplasia. Her serum calcium and parathyroid hormone levels returned to normal after surgery. She delivered a healthy male newborn at gestational age 38 weeks without any complications. Conclusion: PHPT-induced acute pancreatitis during pregnancy is rare. Hypercalcemia, involving both total and ionized calcium, should be investigated in pregnant women who present with acute pancreatitis. Early diagnosis and appropriate management can significantly improve the maternal, fetal, and pregnancy outcomes. Keywords: Hypercalcemia, Recurrent pancreatitis, Pregnancy, Primary hyperparathyroidism, Parathyroid hyperplasia

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