scholarly journals Exercise-induced vasodilation is associated with menopause stage in healthy middle-aged women

2012 ◽  
Vol 37 (3) ◽  
pp. 418-424 ◽  
Author(s):  
David J. Moore ◽  
Joaquin U. Gonzales ◽  
Steven H. Tucker ◽  
Steriani Elavsky ◽  
David N. Proctor
Keyword(s):  
Ldl Cholesterol ◽  
Middle Aged ◽  
Vascular Conductance ◽  
Femoral Blood Flow ◽  
Perimenopausal Women ◽  
Vascular Responsiveness ◽  
Leg Exercise ◽  
Exercise Hemodynamics ◽  
Femoral Blood ◽  
Exercise Induced

Leg exercise hemodynamics during single-leg knee extensions were compared among healthy groups of early perimenopausal (n = 15), late perimenopausal (n = 12), and early postmenopausal (n = 11) women. Femoral blood flow (FBF) and vascular conductance (FVC) at rest and during very light work rates (0 and 5 W) were similar among all three menopause stage groups. Vascular responses at 10 W (FBF) and 20 W (FBF and FVC) were significantly higher (P < 0.05) in early perimenopausal compared with late perimenopausal women. At 15 and 25 W, FBF and FVC were similar between late perimenopausal and early postmenopausal groups but higher (P < 0.05) in early perimenopausal women as compared with the other two menopausal groups. In the combined sample of all three menopause stage groups, follicle-stimulating hormone was significantly correlated with vascular conductance during submaximal (15 W) exercise (R = –0.56, P < 0.001), even after adjustment for age, fitness, LDL cholesterol, and abdominal fat (R = –0.46, P = 0.005). Collectively, these findings suggest that in middle-aged women, there is an association between menopause stage and leg vascular responsiveness during exercise.

scholarly journals Sex differences in leg vasodilation during graded knee extensor exercise in young adults

2007 ◽  
Vol 103 (5) ◽  
pp. 1583-1591 ◽  
Author(s):  
Beth A. Parker ◽  
Sandra L. Smithmyer ◽  
Justin A. Pelberg ◽  
Aaron D. Mishkin ◽  
Michael D. Herr ◽  
...  
Keyword(s):  
Blood Flow ◽  
Femoral Artery ◽  
Knee Extensor ◽  
Activity Levels ◽  
Vascular Conductance ◽  
Arterial Blood ◽  
Vasodilatory Response ◽  
Femoral Blood Flow ◽  
Femoral Blood ◽  
Response To Exercise

Limb vascular conductance responses to pharmacological and nonexercise vasodilator stimuli are generally augmented in women compared with men. In the present investigation, we tested the hypothesis that exercise-induced vasodilator responses are also greater in women than men. Sixteen women and 15 men (20–30 yr) with similar fitness and activity levels performed graded quadriceps exercise (supine, single-leg knee extensions, 40 contractions/min) to maximal exertion. Active limb hemodynamics (left common femoral artery diameter and volumetric blood flow), heart rate (ECG), and beat-to-beat mean arterial blood pressure (MAP; radial artery tonometry) were measured during each 3-min workload (4.8 and 8 W/stage for women and men, respectively). The hyperemic response to exercise (slope of femoral blood flow vs. workload) was greater ( P < 0.01) in women as was femoral blood flow at workloads >15 W. The leg vasodilatory response to exercise (slope of calculated femoral vascular conductance vs. absolute workload) was also greater in women than in men ( P < 0.01) because of the sex difference in hyperemia and the women's lower MAP (∼10–15 mmHg) at all workloads ( P < 0.05). The femoral artery dilated to a significantly greater extent in the women (∼0.5 mm) than in the men (∼0.1 mm) across all submaximal workloads. At maximal exertion, femoral vascular conductance was lower in the men (men, 18.0 ± 0.6 ml·min−1·mmHg−1; women, 22.6 ± 1.4 ml·min−1·mmHg−1; P < 0.01). Collectively, these findings suggest that the vasodilatory response to dynamic leg exercise is greater in young women vs. men.

Sex-specific Effect Of Age On Submaximal Leg Exercise Hemodynamics In Middle-aged Adults

2010 ◽  
Vol 42 ◽  
pp. 53
Author(s):  
Beth Parker ◽  
Jeffrey Capizzi ◽  
Amanda Augeri ◽  
David Proctor ◽  
Paul Thompson
Keyword(s):  
Specific Effect ◽  
Middle Aged ◽  
Leg Exercise ◽  
Exercise Hemodynamics ◽  
Middle Aged Adults ◽  
Effect Of Age

Sex-specific effect of aging on submaximal leg exercise hemodynamics in middle-aged and older adults

2010 ◽  
Vol 111 (7) ◽  
pp. 1369-1379 ◽  
Author(s):  
Beth Parker ◽  
Jeffrey Capizzi ◽  
Amanda Augeri ◽  
Adam Grimaldi ◽  
David Proctor ◽  
...  
Keyword(s):  
Older Adults ◽  
Specific Effect ◽  
Middle Aged ◽  
Leg Exercise ◽  
Exercise Hemodynamics

scholarly journals Resistance training increases basal limb blood flow and vascular conductance in aging humans

2006 ◽  
Vol 101 (5) ◽  
pp. 1351-1355 ◽  
Author(s):  
Maria M. Anton ◽  
Miriam Y. Cortez-Cooper ◽  
Allison E. DeVan ◽  
Daria B. Neidre ◽  
Jill N. Cook ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Cardiac Output ◽  
Strength Training ◽  
Whole Body ◽  
Control Group ◽  
Limb Blood Flow ◽  
Vascular Conductance ◽  
Femoral Blood Flow ◽  
Femoral Blood

Age-related reductions in basal limb blood flow and vascular conductance are associated with the metabolic syndrome, functional impairments, and osteoporosis. We tested the hypothesis that a strength training program would increase basal femoral blood flow in aging adults. Twenty-six sedentary but healthy middle-aged and older subjects were randomly assigned to either a whole body strength training intervention group (52 ± 2 yr, 3 men, 10 women) who underwent three supervised resistance training sessions per week for 13 wk or a control group (53 ± 2 yr, 4 men, 9 women) who participated in a supervised stretching program. At baseline, there were no significant differences in blood pressure, cardiac output, basal femoral blood flow (via Doppler ultrasound), vascular conductance, and vascular resistance between the two groups. The strength training group increased maximal strength in all the major muscle groups tested ( P < 0.05). Whole body lean body mass increased ( P < 0.05) with strength training, but leg fat-free mass did not. Basal femoral blood flow and vascular conductance increased by 55–60% after strength training (both P < 0.05). No such changes were observed in the control group. In both groups, there were no significant changes in brachial blood pressure, plasma endothelin-1 and angiotensin II concentrations, femoral artery wall thickness, cardiac output, and systemic vascular resistance. Our results indicate that short-term strength training increases basal femoral blood flow and vascular conductance in healthy middle-aged and older adults.

Postexercise Hemodynamics in Patients With Type 2 Diabetes: Effect of Exercise Intensity and Duration

2017 ◽  
Vol 6 (1) ◽  
pp. 1-8
Author(s):  
Thomas K. Pellinger ◽  
Catherine B. Pearce ◽  
Grant H. Simmons ◽  
Jack L. Snitzer
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Blood Flow ◽  
Systolic Blood Pressure ◽  
Vascular Function ◽  
Muscle Blood Flow ◽  
Vascular Conductance ◽  
Femoral Blood Flow ◽  
Femoral Blood

Background: For individuals with type 2 diabetes (T2D), the hemodynamic response to regular exercise is critical for regulating blood glucose, protecting vascular function, and reducing cardiovascular disease risk, but the hemodynamic responses to differing doses of acute exercise in T2D are unclear. We aimed to compare postexercise (PE) hemodynamics in patients with T2D in response to 4 doses of dynamic exercise. Methods: Eight subjects with well-controlled T2D (42–64 years old.; hemoglobin A1c: 6.6% ± 0.9%) participated in 4 study days, during which they exercised on a cycle ergometer at 4 different combinations of exercise duration and intensity: 30 min at 40% V˙O2peak (30@40), 30 min at 60% V˙O2peak (30@60), 60 min at 40% V˙O2peak (60@40), and 60 min at 60% V˙O2peak (60@60). Heart rate, arterial pressure, and femoral blood flow (Doppler ultrasound) were measured pre-exercise and every 15 min through 120 min PE. Femoral vascular conductance was calculated as flow/pressure. Results: Compared with pre-exercise baseline, femoral blood flow and femoral vascular conductance were higher through at least 105 min of recovery in all conditions (all P &lt; .05), except for the 30@40 trial. Compared with the pre-exercise measures, systolic blood pressure was lower through at least 75 min of recovery in all conditions (all P &lt; .05), except for the 30@40 trial. Conclusion: These results suggest that exercise must be at least moderate in intensity or prolonged in duration (&gt;30 min) to promote sustained PE elevations in skeletal muscle blood flow and reductions in systolic blood pressure in patients with T2D.

scholarly journals H2-receptor-mediated vasodilation contributes to postexercise hypotension

2006 ◽  
Vol 100 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Jennifer L. McCord ◽  
Julie M. Beasley ◽  
John R. Halliwill
Keyword(s):  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Potential Contribution ◽  
Vascular Conductance ◽  
Men And Women ◽  
Femoral Blood Flow ◽  
Postexercise Hypotension ◽  
Femoral Blood ◽  
Randomized Control ◽  
Automated Auscultation

The early (∼30 min) postexercise hypotension response after a session of aerobic exercise is due in part to H1-receptor-mediated vasodilation. The purpose of this study was to determine the potential contribution of H2-receptor-mediated vasodilation to postexercise hypotension. We studied 10 healthy normotensive men and women (ages 23.7 ± 3.4 yr) before and through 90 min after a 60-min bout of cycling at 60% peak O2 uptake on randomized control and H2-receptor antagonist days (300 mg oral ranitidine). Arterial pressure (automated auscultation), cardiac output (acetylene washin) and femoral blood flow (Doppler ultrasound) were measured. Vascular conductance was calculated as flow/mean arterial pressure. Sixty minutes postexercise on the control day, femoral (Δ62.3 ± 15.6%, where Δ is change; P < 0.01) and systemic (Δ13.8 ± 5.3%; P = 0.01) vascular conductances were increased, whereas mean arterial pressure was reduced (Δ−6.7 ± 1.1 mmHg; P < 0.01). Conversely, 60 min postexercise with ranitidine, femoral (Δ9.4 ± 9.2%; P = 0.34) and systemic (Δ−2.8 ± 4.8%; P = 0.35) vascular conductances were not elevated and mean arterial pressure was not reduced (Δ−2.2 ± 1.3 mmHg; P = 0.12). Furthermore, postexercise femoral and systemic vascular conductances were lower ( P < 0.05) and mean arterial pressure was higher ( P = 0.01) on the ranitidine day compared with control. Ingestion of ranitidine markedly reduces vasodilation after exercise and blunts postexercise hypotension, suggesting H2-receptor-mediated vasodilation contributes to postexercise hypotension.

scholarly journals Human muscle length-dependent changes in blood flow

2012 ◽  
Vol 112 (4) ◽  
pp. 560-565 ◽  
Author(s):  
John McDaniel ◽  
Stephen J. Ives ◽  
Russell S. Richardson
Keyword(s):  
Blood Flow ◽  
Knee Joint ◽  
Joint Angle ◽  
Muscle Blood Flow ◽  
Muscle Length ◽  
Limb Blood Flow ◽  
Knee Joint Angle ◽  
Femoral Blood Flow ◽  
Femoral Blood ◽  
Cyclic Changes

Although a multitude of factors that influence skeletal muscle blood flow have been extensively investigated, the influence of muscle length on limb blood flow has received little attention. Thus the purpose of this investigation was to determine if cyclic changes in muscle length influence resting blood flow. Nine healthy men (28 ± 4 yr of age) underwent a passive knee extension protocol during which the subjects' knee joint was passively extended and flexed through 100–180° knee joint angle at a rate of 1 cycle per 30 s. Femoral blood flow, cardiac output (CO), heart rate (HR), stroke volume (SV), and mean arterial pressure (MAP) were continuously recorded during the entire protocol. These measurements revealed that slow passive changes in knee joint angle did not have a significant influence on HR, SV, MAP, or CO; however, net femoral blood flow demonstrated a curvilinear increase with knee joint angle ( r2 = 0.98) such that blood flow increased by ∼90% (125 ml/min) across the 80° range of motion. This net change in blood flow was due to a constant antegrade blood flow across knee joint angle and negative relationship between retrograde blood flow and knee joint angle ( r2 = 0.98). Thus, despite the absence of central hemodynamic changes and local metabolic factors, blood flow to the leg was altered by changes in muscle length. Therefore, when designing research protocols, researchers need to be cognizant of the fact that joint angle, and ultimately muscle length, influence limb blood flow.

scholarly journals Effects of bone cement filling in rabbit proximal femoral medullary cavity on distal femoral blood flow and metabolism

2018 ◽  
Vol 46 (12) ◽  
pp. 5237-5244
Author(s):  
Li-Cheng Xi ◽  
Hong-Yu Li ◽  
Ming Zhang ◽  
Si-Cheng Huang
Keyword(s):  
Blood Flow ◽  
Bone Cement ◽  
Rabbit Model ◽  
Experimental System ◽  
Medullary Cavity ◽  
Marrow Cavity ◽  
Femoral Blood Flow ◽  
Femoral Blood ◽  
The Right ◽  
Time Point

Objective A rabbit model was used to evaluate the effects of bone-cemented hip arthroplasty on distal femoral blood flow and metabolism relative to that of the non-cemented contralateral leg. Methods The marrow cavity of the right hind femur was filled with bone cement. At each of the following time points, rabbits were randomly selected to receive an injection of one dose of 99mTc-methylene diphosphonate and then immediately scanned using a gamma camera: immediately postoperatively and at 4 and 8 weeks postoperatively. A BL-410 model biofunction experimental system was used to analyze the acquired images and determine the radioactive counts of each hind leg. Results The X-ray and photographic images of the right femoral bones confirmed successful filling of the marrow cavity with bone cement. The radioactive counts were significantly lower in the experimental than control legs at each time point. The ratio of the radioactive count of the experimental to control leg increased considerably at each time point, but each ratio was <1. Conclusion Blocking the proximal femoral medullary cavity with bone cement was associated with significant lowering of the blood circulation of the femur and marrow, decreasing the distal femoral blood flow and bone metabolic rate.

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