Dietary Strategies to Promote Glycogen Synthesis After Exercise

2001 ◽  
Vol 26 (S1) ◽  
pp. S236-S245 ◽  
Author(s):  
John L. Ivy
Keyword(s):  
Muscle Glycogen ◽  
Tissue Repair ◽  
Glycogen Synthesis ◽  
Effective Means ◽  
Post Exercise ◽  
Muscle Glycogen Synthesis ◽  
Added Benefit ◽  
Glycogen Stores ◽  
Dietary Strategies ◽  
Carbohydrate Supplement

Muscle glycogen is an essential fuel for prolonged intense exercise, and therefore it is important that the glycogen stores be copious for competition and strenuous training regimens. While early research focused on means of increasing the muscle glycogen stores in preparation for competition and its day-to-day replenishment, recent research has focused on the most effective means of promoting its replenishment during the early hours of recovery. It has been observed that muscle glycogen synthesis is twice as rapid if carbohydrate is consumed immediately after exercise as opposed to waiting several hours, and that a rapid rate of synthesis can be maintained if carbohydrate is consumed on a regular basis. For example, supplementing at 30-min intervals at a rate of 1.2 to 1.5 g CHO kg-1 body wt h-1 appears to maximize synthesis for a period of 4- to 5-h post exercise. If a lighter carbohydrate supplement is desired, however, glycogen synthesis can be enhanced with the addition of protein and certain amino acids. Furthermore, the combination of carbohydrate and protein has the added benefit of stimulating amino acid transport, protein synthesis and muscle tissue repair. Research suggests that aerobic peiformance following recovery is related to the degree of muscle glycogen replenishment.

scholarly journals Postexercise muscle glycogen resynthesis in humans

2017 ◽  
Vol 122 (5) ◽  
pp. 1055-1067 ◽  
Author(s):  
Louise M. Burke ◽  
Luc J. C. van Loon ◽  
John A. Hawley
Keyword(s):  
Muscle Glycogen ◽  
Glycogen Synthesis ◽  
Practical Interest ◽  
Time Frame ◽  
Glycogen Storage ◽  
Future Research ◽  
Glycogen Depletion ◽  
Muscle Glycogen Synthesis ◽  
The 1960S ◽  
Dietary Strategies

Since the pioneering studies conducted in the 1960s in which glycogen status was investigated using the muscle biopsy technique, sports scientists have developed a sophisticated appreciation of the role of glycogen in cellular adaptation and exercise performance, as well as sites of storage of this important metabolic fuel. While sports nutrition guidelines have evolved during the past decade to incorporate sport-specific and periodized manipulation of carbohydrate (CHO) availability, athletes attempt to maximize muscle glycogen synthesis between important workouts or competitive events so that fuel stores closely match the demands of the prescribed exercise. Therefore, it is important to understand the factors that enhance or impair this biphasic process. In the early postexercise period (0–4 h), glycogen depletion provides a strong drive for its own resynthesis, with the provision of CHO (~1 g/kg body mass) optimizing this process. During the later phase of recovery (4–24 h), CHO intake should meet the anticipated fuel needs of the training/competition, with the type, form, and pattern of intake being less important than total intake. Dietary strategies that can enhance glycogen synthesis from suboptimal amounts of CHO or energy intake are of practical interest to many athletes; in this scenario, the coingestion of protein with CHO can assist glycogen storage. Future research should identify other factors that enhance the rate of synthesis of glycogen storage in a limited time frame, improve glycogen storage from a limited CHO intake, or increase muscle glycogen supercompensation.

scholarly journals Effect of different post-exercise sugar diets on the rate of muscle glycogen synthesis

1987 ◽  
Vol 19 (5) ◽  
pp. 491???496 ◽  
Author(s):  
PER C. S. BLOM ◽  
ARNE T. H??STMARK ◽  
ODD VAAGE ◽  
KRISTIN R. KARDEL ◽  
SVERRE M??HLUM
Keyword(s):  
Muscle Glycogen ◽  
Glycogen Synthesis ◽  
Post Exercise ◽  
Muscle Glycogen Synthesis

Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle

2008 ◽  
Vol 294 (1) ◽  
pp. E28-E35 ◽  
Author(s):  
Michale Bouskila ◽  
Michael F. Hirshman ◽  
Jørgen Jensen ◽  
Laurie J. Goodyear ◽  
Kei Sakamoto
Keyword(s):  
Skeletal Muscle ◽  
Glucose Uptake ◽  
Muscle Glycogen ◽  
Glycogen Content ◽  
Glycogen Synthase ◽  
Glycogen Synthesis ◽  
Wild Type ◽  
Muscle Glycogen Synthesis ◽  
Mutant Forms

Insulin promotes dephosphorylation and activation of glycogen synthase (GS) by inactivating glycogen synthase kinase (GSK) 3 through phosphorylation. Insulin also promotes glucose uptake and glucose 6-phosphate (G-6- P) production, which allosterically activates GS. The relative importance of these two regulatory mechanisms in the activation of GS in vivo is unknown. The aim of this study was to investigate if dephosphorylation of GS mediated via GSK3 is required for normal glycogen synthesis in skeletal muscle with insulin. We employed GSK3 knockin mice in which wild-type GSK3α and -β genes are replaced with mutant forms (GSK3α/βS21A/S21A/S9A/S9A), which are nonresponsive to insulin. Although insulin failed to promote dephosphorylation and activation of GS in GSK3α/βS21A/S21A/S9A/S9Amice, glycogen content in different muscles from these mice was similar compared with wild-type mice. Basal and epinephrine-stimulated activity of muscle glycogen phosphorylase was comparable between wild-type and GSK3 knockin mice. Incubation of isolated soleus muscle in Krebs buffer containing 5.5 mM glucose in the presence or absence of insulin revealed that the levels of G-6- P, the rate of [14C]glucose incorporation into glycogen, and an increase in total glycogen content were similar between wild-type and GSK3 knockin mice. Injection of glucose containing 2-deoxy-[3H]glucose and [14C]glucose also resulted in similar rates of muscle glucose uptake and glycogen synthesis in vivo between wild-type and GSK3 knockin mice. These results suggest that insulin-mediated inhibition of GSK3 is not a rate-limiting step in muscle glycogen synthesis in mice. This suggests that allosteric regulation of GS by G-6- P may play a key role in insulin-stimulated muscle glycogen synthesis in vivo.

Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis?

2020 ◽  
Vol 207 ◽  
pp. 111877 ◽  
Author(s):  
Kenia Mendes Rodrigues Castro ◽  
Rodrigo Leal de Paiva Carvalho ◽  
Geraldo Marco Rosa Junior ◽  
Beatriz Antoniassi Tavares ◽  
Luis Henrique Simionato ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Muscle Glycogen ◽  
Glycogen Synthesis ◽  
Photobiomodulation Therapy ◽  
Control Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Muscle Glycogen Synthesis

scholarly journals Reposición del Glucógeno Muscular en la Recuperación del Deportista

2019 ◽  
Vol 8 (1) ◽  
pp. 57-66 ◽  
Author(s):  
F. Mata-Ordoñez ◽  
M. Grimaldi-Puyana ◽  
A. J. Sánchez-Oliver
Keyword(s):  
Muscle Glycogen ◽  
Athletic Performance ◽  
Recovery Phase ◽  
Post Exercise ◽  
Nutritional Interventions ◽  
Carbohydrate Consumption ◽  
Cellular Processes ◽  
Intense Training ◽  
Post Exercise Recovery ◽  
Glycogen Stores

Las estrategias nutricionales durante la fase de recuperación del deportista son fundamentales. Uno de los principales objetivos de la recuperación es la reposición del glucógeno muscular. Este aspecto se hace más importante cuando los deportistas se enfrentan a entrenamientos intensos o eventos competitivos con cortos periodos de recuperación. Además, la manipulación deliberada de su disponibilidad puede mejorar las adaptaciones moleculares al entrenamiento. La presente revisión tiene por objetivo informar sobre los aspectos fisiológicos básicos de esta situación, así como conocer el momento del consumo, la cantidad, el tipo y la interacción de diferentes nutrientes con los hidratos de carbono, para poder maximizar o jugar con la reposición del mismo en función de las necesidades y/o las estrategias planteadas. El glucógeno ya no debe ser visto como un simple almacén de energía sino como una molécula que puede desencadenar numerosos procesos celulares importantes para el deportista. Nutritional interventions play a fundamental role during the post-exercise recovery phase. One of the main goals of recovery is restoring muscle glycogen stores. This becomes more important when athletes are subjected to intense training or competition with short recovery periods be-tween bouts. Furthermore, manipulating muscle glycogen availability can improve molecular adaptations to training. The objective of this review is thus to present the basic physiological aspects of this phenomenon, and to discuss carbohydrate consumption, timing, type, and amount, as well as its interaction with different nutrients, in order to maximize or play with the restoration of muscle glycogen depending on the needs and/or the strategies proposed. Glyco-gen should no longer be seen as a simple form of energy storage, but as a molecule that can trigger numerous cellular processes important for athletic performance.

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