A short bout of stair climbing–descending exercise attenuates postprandial hyperglycemia in middle-aged males with impaired glucose tolerance

2012 ◽  
Vol 37 (1) ◽  
pp. 193-196 ◽  
Author(s):  
Tetsuo Takaishi ◽  
Kenro Imaeda ◽  
Tsutomu Tanaka ◽  
Toshio Moritani ◽  
Tatsuya Hayashi
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Exercise Intensity ◽  
Postprandial Hyperglycemia ◽  
Moderate Level ◽  
Stair Climbing ◽  
Middle Aged ◽  
Short Bout ◽  
Blood Glucose Concentrations

Exercise is a useful modality to ameliorate postprandial hyperglycemia. Here we show that a short bout (∼6 min) of stair climbing–descending exercise (STAIR) starting at 90 min after meal accelerates the decrease in blood glucose concentrations in middle-aged sedentary men with impaired glucose tolerance, although STAIR is easy to perform and keeps the exercise intensity at a moderate level.

scholarly journals Evaluation of a Standardized Extract fromMorus albaagainstα-Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double-Blind Clinical Trial

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Seung Hwan Hwang ◽  
Hong Mei Li ◽  
Soon Sung Lim ◽  
Zhiqiang Wang ◽  
Jae-Seung Hong ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Clinical Signs ◽  
Inhibitory Effect ◽  
Postprandial Hyperglycemia ◽  
Dependent Manner ◽  
Double Blind ◽  
Double Blind Clinical Trial

To evaluate the antihyperglycemic effect of a standardized extract of the leaves ofMorus alba(SEMA), the present study was designed to investigate theα-glucosidase inhibitory effect and acute single oral toxicity as well as evaluate blood glucose reduction in animals and in patients with impaired glucose tolerance in a randomized double-blind clinical trial. SEMA was found to inhibitα-glucosidase at a fourfold higher level than the positive control (acarbose), in a concentration-dependent manner. Moreover, blood glucose concentration was suppressed by SEMAin vivo. Clinical signs and weight changes were observed when conducting an evaluation of the acute toxicity of SEMA through a single-time administration, with clinical observation conducted more than once each day. After administration of the SEMA, observation was for 14 days; all of the animals did not die and did not show any abnormal symptoms. In addition, the inhibitory effects of rice coated with SEMA were evaluated in a group of impaired glucose tolerance patients on postprandial glucose and a group of normal persons, and results showed that SEMA had a clear inhibitory effect on postprandial hyperglycemia in both groups. Overall, SEMA showed excellent potential in the present study as a material for improving postprandial hyperglycemia.

scholarly journals The role of apolipoprotein E and glucose intolerance in gallstone disease in middle aged subjects

Gut ◽  
1999 ◽  
Vol 44 (4) ◽  
pp. 557-562 ◽  
Author(s):  
M Niemi ◽  
K Kervinen ◽  
A Rantala ◽  
H Kauma ◽  
M Päivänsalo ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Apolipoprotein E ◽  
Impaired Glucose Tolerance ◽  
Serum Insulin ◽  
Gallstone Disease ◽  
Significant Risk ◽  
Population Level ◽  
Oral Glucose ◽  
Middle Aged

BACKGROUNDThe polymorphism of apolipoprotein E has been suggested to be associated with the cholesterol content of gallstones, the crystallisation rate of gall bladder bile, and the prevalence of gallstone disease (GSD).AIMSTo investigate whether apolipoprotein E polymorphism modulates the susceptibility to GSD at the population level and to study the possible associations between impaired glucose tolerance, diabetes, and GSD.METHODSApolipoprotein E phenotypes were determined in a middle aged cohort of 261 randomly selected hypertensive men, 259 control men, 257 hypertensive women, and 267 control women. All subjects without a documented history of diabetes were submitted to a two hour oral glucose tolerance test (OGTT). GSD was verified by ultrasonography.RESULTSIn women with apolipoprotein E2 (phenotypes E2/2, 2/3, and 2/4) compared with women without E2 (E3/3, 4/3, and 4/4), the odds ratio for GSD was 0.28 (95% confidence interval 0.08–0.92). There was no protective effect in men. The relative risk for GSD was 1.2 (0.8–1.7) for hypertensive women and 1.8 (1.0–2.7) for hypertensive men. In a stepwise multiple logistic regression model, E2 protected against GSD in women, whereas two hour blood glucose in the OGTT, serum insulin, and plasma triglycerides were risk factors. Elevated blood glucose during the OGTT was also a significant risk factor for GSD in men.CONCLUSIONSThe data suggest that apolipoprotein E2 is a genetic factor providing protection against GSD in women. In contrast, impaired glucose tolerance and frank diabetes are associated with the risk of GSD.

scholarly journals Diabetes mellitus and impaired glucose tolerance in urban adult population

2014 ◽  
Vol 60 (2) ◽  
pp. 118-124 ◽  
Author(s):  
Walter Rodrigues Júnior ◽  
Sandra Cristina Nicodemo Gaban ◽  
Elenir Rose Jardim Cury Pontes ◽  
Celso Correia Souza ◽  
Lilian Patussi Gimenes ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Adult Population ◽  
Oral Glucose ◽  
Diabetic Patients ◽  
Mato Grosso ◽  
Strict Adherence ◽  
Family History Of Diabetes

Objective: Estimating the prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) in the urban population aged between 30 and 69 years in the municipality of Campo Grande, state of Mato Grosso do Sul, Brazil. Methods: Population-based cross-sectional study conducted between October/2009 and February/2011. The investigation included the determination of fasting glucose and participants with blood glucose ≥ 200 mg/dL were considered diabetic. Nondiabetic patients, which showed blood glucose ≥ 100 mg/dL and < 200 mg/dL, underwent an oral glucose tolerance test (OGTT) to investigate whether they had DM or IGT. Results: 1.429 individuals participated in this investigation. The general prevalence, adjusted for sex and age, were: 12.3% for DM (95%CI: 10.5 to 13.9%) and 7.1% for IGT (95%CI: 5.7 to 8.4%). There was a higher prevalence of DM with increasing age in people with low educational level, family history of diabetes, overweight, obesity and central obesity. Among diabetic patients (n = 195), 25% were unaware they had the disease and were diagnosed through investigation. Among patients who already knew they had DM (n = 146), 37% were unaware of the potential chronic complications. Conclusion: This study confirms the increased prevalence of DM in Brazil and emphasizes the need for early diagnosis, as well as the importance of strict adherence to medical treatment in order to prevent its much feared complications.

Prevalence of diabetes mellitus and impaired glucose tolerance in a middle-aged Finnish population

1995 ◽  
Vol 13 (3) ◽  
pp. 222-228 ◽  
Author(s):  
Ulla Rajala ◽  
Sirkka Keinänen-Kiukaanniemi ◽  
Aira Uusimäki ◽  
Kari Reijula ◽  
Sirkka-Liisa Kivelä
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Middle Aged ◽  
Finnish Population ◽  
Prevalence Of Diabetes Mellitus

scholarly journals Endocrinological analysis of endothelium-dependent vasodilation in middle-aged patients with impaired glucose tolerance during prediabetes mellitus

2014 ◽  
Vol 7 (3) ◽  
pp. 697-702 ◽  
Author(s):  
YIPING LIU ◽  
JIANWEI LI ◽  
ZHENGHONG ZHANG ◽  
YEDONG TANG ◽  
ZUOSONG CHEN ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Middle Aged ◽  
Aged Patients

scholarly journals Screening of newly-diagnosed adults with Tuberculosis for Diabetes mellitus and Impaired Glucose Tolerance in a Local Government Area in Ogun State, Nigeria

2019 ◽  
pp. 146-155
Author(s):  
AA Salako ◽  
OA Adenowo ◽  
OE Amoran ◽  
O Odusan ◽  
GJ Mautin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Treatment Outcomes ◽  
Fasting Blood Glucose ◽  
Newly Diagnosed ◽  
Glucose Levels ◽  
Ogun State ◽  
Blood Glucose Levels

Background: Emerging patterns in epidemiological transitions have led to increased risk for Non-Communicable Diseases and infectious conditions globally. Diabetes mellitus (DM) in a population is one such risk factor that could lead to the development of Tuberculosis (TB) due to weakened immune functions in affected persons, with implications for mortality. If not diagnosed early, DM also leads to poor treatment outcomes in TB. Objective: To assess the prevalence of DM and impaired glucose tolerance (pre-diabetes) among newly diagnosed tuberculosis cases in Ijebu-Ode Local Government Area of Ogun State, Nigeria. Methods: This cross-sectional study was conducted among 100 newly diagnosed Pulmonary TB patients in ljebu-Ode LGA. The patients were selected from four health facilities and were screened for elevated Fasting Blood Glucose levels using a laboratory spectrophotometer (glucose oxidase method). Results: The mean age of the 100 study participants was 33 years (± 9.82), with ages within 19 -62 years. Eleven (11.0%) had elevated blood glucose levels suggestive of DM, while 20 (20.0%) had impaired fasting blood glucose levels. Among these 31 patients, 18 (58.0%) were males while 13 (42.0%) were females. The modal ages were within 20-39 years. Conclusion: Screening for DM by healthcare providers should be routinely conducted before commencing TB patients on treatment. This will aid early detection, improve treatment outcomes of TB and prevent mortality among patients with these co-morbidities.

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