A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults

2009 ◽  
Vol 34 (2) ◽  
pp. 89-98 ◽  
Author(s):  
Stephen M. Cornish ◽  
Philip D. Chilibeck ◽  
Lisa Paus-Jennsen ◽  
H. Jay Biem ◽  
Talaei Khozani ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Blood Pressure ◽  
Older Adults ◽  
Metabolic Syndrome ◽  
Body Composition ◽  
Bone Mineral ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Z Score ◽  
Mineral Density

A randomized double-blind placebo controlled study design was used to assess the effects of flaxseed lignan complex supplementation during exercise training on a metabolic syndrome composite score and osteoporosis risk in older adults. A total of 100 subjects (≥50 years) were randomized to receive flaxseed lignan (543 mg·day–1 in a 4050 mg complex) or placebo while completing a 6 month walking program (30–60 min·day–1, 5–6 days·week–1). Fasting serum glucose, triacylglycerol (TAG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, total cholesterol, interleukin-6, and tumor necrosis factor-α were measured every 2 months, while body composition, bone mineral density, and resting blood pressure were assessed at baseline and at 6 months. A composite Z score of 6 risk factors for metabolic syndrome (fasting glucose, HDL cholesterol, TAG, abdominal adiposity, blood pressure, and inflammatory cytokines) was calculated at baseline and at 6 months. Men taking placebo increased metabolic syndrome composite Z score (p < 0.05), but there were no changes in the other groups. A significant group × sex × time interaction was noted for TAG (p = 0.017) and diastolic blood pressure (p = 0.046), with men taking flaxseed lignan decreasing diastolic blood pressure relative to men taking placebo, and men taking placebo increasing TAG relative to men taking flax lignan. There were no differences between groups for change in bone measures, body composition, lipoproteins, or cytokines. Males taking the flaxseed lignan complex reduced metabolic syndrome score relative to men taking placebo, but a similar trend was not seen in females. Flaxseed lignan had no effect on bone mineral density or content, body composition, lipoproteins, glucose, or inflammation.

scholarly journals LIVING ALONE IS ASSOCIATED WITH POORER PHYSICAL FUNCTION AND BONE MINERAL DENSITY IN ICELANDIC OLD ADULTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S482-S482
Author(s):  
Alfons Ramel
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Physical Function ◽  
Bone Mineral ◽  
Community Dwelling ◽  
Living Alone ◽  
Z Score ◽  
Mineral Density ◽  
Old Adults ◽  
Wide Range

Abstract Background: Loneliness and living alone have been significant public health concerns among older adults given their association with a wide range of adverse health outcomes. Aim: The aim of this study was to examine whether living alone is associated with physical function and bone health in community-dwelling older adults. Methods: This was a secondary analysis of existing cross-sectional data of old adults (N=182, 73.7±5.7yrs, 58.2% female) from the Reykjavik capital area in Iceland. Information on socioeconomics, health, dietary intake and physical function was collected. 25-hydroxy-vitamin D (25OHD) and bone mineral density (BM were grouped retrospectively into “living alone” and into “in cohabitation”. Results: Of our subjects, 76.4% were in cohabitation and and 23.6% lived alone. Participants who lived alone were older (74.5±5.6 vs. 72.1±5.0,P=0.008) and more often female (74.4 vs. 53.2%,P=0.014), but there were no differences in education, smoking, number of medications, physical activity (PA) or body mass index (BMI). According to age and gender corrected analyses, participants in cohabitation had higher grip strength (6.2±2.4lb,P=0.011), higher 25OHD (13.1±6.3nmol/L,P=0.037) and higher BMD (z-score lumbal: 1.195±0.417,P=0.005; z-score femur: 0.421±0.219,P=0.054; z-score total: 0.846±0.290,P=0.004). Statistical correction for PA, BMI, education and fish oil intake did not change the results. Conclusion: In comparison to old adults who live in cohabitation, Icelandic old adults who live alone have poorer physical function, lower 25OHD and lower BMD, which increases their risk for wrist or hip fracture. These differences between groups were not explained by physical, dietary or social confounding variables.

Abstract P111: A Cluster Randomized Controlled Trial to Examine the Effects of Tai Chi and Walking Exercises on Weight Loss, Metabolic Syndrome Parameters, and Bone Mineral Density

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Yao Jie Xie ◽  
Stanley Sai-chuen Hui ◽  
Timothy Chi-yui Kwok ◽  
Jean Woo
Keyword(s):  
Bone Mineral Density ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Weight Loss ◽  
Body Weight ◽  
Waist Circumference ◽  
Lean Mass ◽  
Tai Chi ◽  
Density Lipoprotein ◽  
Mineral Density

Introduction: Tai Chi and walking are both moderate-intensity physical activity (PA) that can be easily practiced in daily life. The purpose of this study was to better understand that after practicing these two types of PAs in a relative short term and keeping the stable dietary intake in this period, how much body weight would be reduced and what extent the metabolic syndrome parameters would be improved; and if a significant weight loss was observed, whether this exercise-induced weight loss had adverse effect on bone mineral density (BMD). Methods: Three-hundred seventy-four healthy and physically inactive adults (45.8±5.3 years) from 9 geographic areas in Hong Kong were randomized to 12 weeks training (45 minutes per day, 5 days per week) of Tai Chi (n=124) or self-paced walking (n=121), or control group (n=129) at area level. Body weight, fat and lean mass, waist circumference, blood pressure and regional BMD, as well as the fasting blood samples were obtained at the beginning and end of trial. Fasting blood glucose (FBG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides were analyzed. Results: On average, Tai Chi and walking groups lost 0.50 and 0.76 kg of body weight, 0.47 and 0.59 kg of fat mass, respectively (all p<0.001). No significant changes were observed for lean mass and BMD. Two intervention groups had significant improvements in waist circumference and FBG. The between-group difference of waist circumference and FBG was -3.7 cm and -0.18 mmol/L for Tai Chi vs. control; and -4.1 cm and -0.22 mmol/L for walking vs. control (all p<0.001). No significant differences were observed regarding blood pressure, total cholesterol, HDL-C, LDL-C and triglycerides compared to control (all p>0.05). The effects on all outcomes between Tai Chi and walking were similar (all p>0.05). Among intervention groups, change in lean mass, not fat mass or total weight loss, was significantly correlated to the change in BMD. Conclusions: 12-week Tai Chi and walking exercises can produce moderate weight loss and improve the waist circumference and FBG in middle-aged Hong Kong Chinese people, with no additional effects on BMD.

The Relationship between Risk Factors for Metabolic Syndrome and Bone Mineral Density in Menopausal Korean Women

2020 ◽  
Author(s):  
Seok-Hee KIM ◽  
Jooyoung KIM
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Bone Mineral ◽  
Korean Women ◽  
Mineral Density ◽  
Significant Difference ◽  
The Relationship

Background: The risk factors of metabolic syndrome (MetS) in menopausal women are potential causes of osteoporosis. However, there is no consensus on this. We aimed to determine the relationship between risk factors of MetS and bone mineral density (BMD) in menopausal Korean women. Methods: We enrolled 205 menopausal Korean women who visited a health promotion center in Seoul in 2015 and divided them into the following two groups according to the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria with modified waist-circumference criteria: the non-MetS group (Group 1, n=90) and the MetS group (Group 2, n=115). Anthropometric parameters and clinical parameters, including blood pressure, blood lipid profile (cholesterol, triglycerides), and fasting blood sugar levels were recorded for all participants. BMD at the lumbar spine was determined using dual-energy X-ray absorptiometry (DEXA). The relationship between the risk factors of MetS and bone mineral density was analyzed by statistical methods. Results: There was no significant difference in risk factors of MetS between the groups. In correlation tests, waist circumference showed a significant association with body surface area (BSA) (r = -0.242, P < 0.001). Diastolic blood pressure was correlated with BSA (r = 0.186, P < 0.01) and bone mineral content (BMC) (r = 0.161, P < 0.05). However, multiple regression analysis showed no significant relationship between MetS risk factors and BMD. Conclusion: The risk factors of MetS did not affect BMD in menopausal Korean women. Follow-up studies with a larger study population are necessary size to allow the investigation of other research variables.

scholarly journals Bone mineral density and body composition in adolescents with failure to thrive

2010 ◽  
Vol 8 (2) ◽  
pp. 168-174
Author(s):  
Thiago Sacchetto de Andrade ◽  
Luiz Anderson Lopes ◽  
Marcelo de Medeiros Pinheiro ◽  
Vera Lucia Szejnfeld ◽  
José Augusto de Aguiar Carrazedo Taddei
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Bone Mass ◽  
Bone Mineral ◽  
Fat Mass ◽  
Failure To Thrive ◽  
Fat Free Mass ◽  
Z Score ◽  
Mineral Density ◽  
Total Fat

ABSTRACT Objective To evaluate bone mineral mass in adolescents with failure to thrive in relation to body composition. Methods A case control study involving 126 adolescents (15 to 19 years), in final puberty maturation being 76 eutrophic and 50 with failure to thrive (genetic or constitutional delay of growth), of matching ages, gender and pubertal maturation. The weight, height and calculated Z score for height/age and body mass index; bone mineral content, bone mineral density and adjusted bone mineral density were established for total body, lower back and femur; total fat-free mass and height-adjusted fat-free mass index, total fat mass and height-adjusted. The statistical analyses were performed using the Student's t-test (weight, height and body composition); Mann-Whitney test (bone mass) and multiple linear regression (bone mass determinants). Results weight, height and height/age Z-score were significantly higher among eutrophic subjects. Both groups did not show statistically significant differences for fat mass, percentage of fat mass, total fat mass height adjusted and fat-free mass index height sadjusted. However, total free fat maass was smaller for the failure to thrive group. Conclusions There was no statistically significant difference for bone mass measurements among adolescents with failure to thrive; however, the factors that determine bone mass formation should be better studied due to the positive correlation with free fat mass detected in these individuals.

Hearing sensitivity and bone mineral density in older adults: the Health, Aging and Body Composition Study

2005 ◽  
Vol 16 (12) ◽  
pp. 1675-1682 ◽  
Author(s):  
Elizabeth P. Helzner ◽  
Jane A. Cauley ◽  
Sheila R. Pratt ◽  
Steven R. Wisniewski ◽  
Evelyn O. Talbott ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Body Composition ◽  
Bone Mineral ◽  
Mineral Density ◽  
Hearing Sensitivity ◽  
Body Composition Study ◽  
Health Aging ◽  
Composition Study

Association between vitamin D and bone mineral density in post-menopausal women with metabolic syndrome

2015 ◽  
Vol 22 (1) ◽  
pp. 7-14
Author(s):  
Jolanta Dadonienė ◽  
Alma Čypienė ◽  
Egidija Rinkūnienė ◽  
Jolita Badarienė ◽  
Jelizaveta Burca ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Bone Mineral ◽  
Density Lipoprotein ◽  
Serum Glucose ◽  
Mineral Density ◽  
Normal Bone Mineral Density ◽  
Menopausal Women ◽  
Post Menopausal

Background. The aim of this study was to identify the relation between vitamin D level and mineral bone density in post-menopausal women with metabolic syndrome. Materials and methods. This study included 100 post-menopausal women at age between 50 and 65 with metabolic syndrome. All participants underwent anthropometric measurements. Laboratory tests were performed to determine lipid profile, serum glucose, creatinine, C-reactive protein, vitamin D (25(OH) D), ionized calcium concentration and urine albumin / creatinine ratio. Bone mineral density of the lumbar spine (L1– L4) and total hip was measured by dual-energy X-ray absorptiometry. Results. According to the vitamin D concentration level in the blood all women were divided into four groups: the average failure was observed in 57%, mild failure in 33%, severe failure in 5%; and only 5% of women had normal vitamin levels. The mean 25(OH) D level was 47.40  ±  16.91  nmol/l. According to bone densitometry we found that 77% of all participants had normal bone mineral density, 22% had osteopenia and 5% were diagnosed with osteoporosis. No correlation was found between bone mineral density and 25(OH)  D levels. We found a weak positive correlation between high density lipoprotein cholesterol and 25(OH) D (r = 0.3, p 

scholarly journals RELATIONSHIP BETWEEN BONE MINERAL DENSITY AND BODY COMPOSITION IN ELDERLY

2018 ◽  
Vol 26 (1) ◽  
pp. 27-29 ◽  
Author(s):  
ANGÉLICA CASTILHO ALONSO ◽  
TUANE ANDREATTA GONÇALVES ◽  
JENIFER KRISTINA ALVES DE ALMEIDA ◽  
ADRIANA MACHADO-LIMA ◽  
RITA DE CÁSSIA ERNANDES ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Body Composition ◽  
Soft Tissue ◽  
Bone Mineral ◽  
The Body ◽  
Inclusion Criteria ◽  
Mineral Density ◽  
Level Of Evidence ◽  
Healthy Older Adults

ABSTRACT Objective: To evaluate the association between bone mineral density (BMD) and body composition in healthy older adults at different skeletal sites. Methods: We analyzed 87 medical records and BMD along with the body composition of men ranging from 60 to 87 years of age (mean: 68.5, standard deviation: 6.5). Inclusion criteria were normal BMD values (T-score greater than or equal to -1.0) and body mass index within normal or overweight range (18.5 to 29.5 kg/m2). Body composition was evaluated using bone densitometry with dual-energy X-ray absorptiometry (DEXA) in a LUNAR-DPX apparatus. Results: Greater lean mass, fat mass, and soft tissue was associated with better BMD values in older adults, and higher age was associated with poorer BMD. Conclusion: Body composition (lean and fat masses and soft tissue) in older men is positively associated with BMD at all body sites (arms, legs, and trunk). Level of Evidence II; Prognostic studies - Investigating the effect of a patient characteristic on the outcome of disease.

scholarly journals Evaluation of Body Composition, Physical Activity, and Food Intake in Patients with Inborn Errors of Intermediary Metabolism

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2111
Author(s):  
María-José de Castro ◽  
Paula Sánchez-Pintos ◽  
Nisreem Abdelaziz-Salem ◽  
Rosaura Leis ◽  
María L. Couce
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Body Composition ◽  
Amino Acid ◽  
Food Intake ◽  
Bone Mineral ◽  
Dietary Treatment ◽  
Z Score ◽  
Mineral Density ◽  
Inborn Errors

Children with inborn errors of intermediary metabolism (IEiM) must follow special diets that restrict their intake of essential nutrients and may compromise normal growth and development. We evaluated body composition, bone mineral density, physical activity, and food intake in IEiM patients undergoing dietary treatment. IEiM patients (n = 99) aged 5–19 years and healthy age- and sex-matched controls (n = 98) were recruited and underwent dual-energy X-ray absorptiometry to evaluate anthropometric characteristics and body composition. Data on food intake and physical activity were also collected using validated questionnaires. The height z-score was significantly lower in IEiM patients than controls (−0.28 vs. 0.15; p = 0.008), particularly in those with carbohydrate and amino acid metabolism disorders. Significant differences in adiposity were observed between patients and controls for the waist circumference z-score (−0.08 vs. −0.58; p = 0.005), but not the body mass index z-score (0.56 vs. 0.42; p = 0.279). IEiM patients had a significantly lower total bone mineral density (BMD) than controls (0.89 vs. 1.6; p = 0.001) and a higher risk of osteopenia (z-score < −2, 33.3% vs. 20.4%) and osteoporosis (z-score < −2.5, 7.1% vs. 0%), but none presented fractures. There was a significant positive correlation between natural protein intake and BMD. Our results indicate that patients with IEiM undergoing dietary treatment, especially those with amino acid and carbohydrate metabolism disorders, present alterations in body composition, including a reduced height, a tendency towards overweight and obesity, and a reduced BMD.

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