Alpha-linolenic acid supplementation and resistance training in older adults

2009 ◽  
Vol 34 (1) ◽  
pp. 49-59 ◽  
Author(s):  
Stephen M. Cornish ◽  
Philip D. Chilibeck
Keyword(s):  
Older Adults ◽  
Resistance Training ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Muscle Thickness ◽  
Alpha Linolenic Acid ◽  
Resistance Training Program ◽  
Tnf Α ◽  
Total Body

Increased inflammation with aging has been linked to sarcopenia. The purpose of this study was to evaluate the effects of supplementing older adults with alpha-linolenic acid (ALA) during a resistance training program, based on the hypothesis that ALA decreases the plasma concentration of the inflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-6, which in turn would improve muscle size and strength. Fifty-one older adults (65.4 ± 0.8 years) were randomized to receive ALA in flax oil (~14 g·day–1) or placebo for 12 weeks while completing a resistance training program (3 days a week). Subjects were evaluated at baseline and after 12 weeks for muscle thickness of knee and elbow flexors and extensors (B-mode ultrasound), muscle strength (1 repetition maximum), body composition (dual energy X-ray absorptiometry), and concentrations of TNF-α and IL-6. Males supplementing with ALA decreased IL-6 concentration over the 12 weeks (62 ± 36% decrease; p = 0.003), with no other changes in inflammatory cytokines. Chest and leg press strength, lean tissue mass, muscle thickness, hip bone mineral content and density, and total bone mineral content significantly increased, and percent fat and total body mass decreased with training (p < 0.05), with the only benefit of ALA being a significantly greater increase in knee flexor muscle thickness in males (p < 0.05). Total-body bone mineral density improved in the placebo group, with no change in the ALA group (p = 0.05). ALA supplementation lowers the IL-6 concentration in older men but not women, but had minimal effect on muscle mass and strength during resistance training.

scholarly journals The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study

2021 ◽  
Vol 18 (10) ◽  
pp. 5365
Author(s):  
Annie M. Constable ◽  
Josie E. Porter ◽  
Danielle Benger ◽  
Dimitris Vlachopoulos ◽  
Alan R. Barker ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Vigorous Physical Activity ◽  
Normal Weight ◽  
Cross Sectional ◽  
Prepubertal Children ◽  
Total Body ◽  
The Relationship

Purpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of this study was to examine whether the relationship between MVPA and total body less head (TBLH) BMC is mediated or moderated by free leptin index in prepubertal children. Methods: We performed a cross-sectional analysis on 401 children (194 girls) from baseline examinations of the Physical Activity and Nutrition in Childhood Study. We applied the four-way decomposition mediation analysis method to assess whether free leptin index, measured from fasted blood samples, mediated the relationship between accelerometer-measured MVPA and TBLH BMC measured by dual-energy X-ray absorptiometry. Results: MVPA had a positive controlled direct effect on TBLH BMC in girls and boys (β = 0.010 to 0.011, p < 0.05). There was no mediation or interaction between MVPA, free leptin index and TBLH BMC in girls or boys (β = −0.000 to 0.001, p > 0.05). Conclusion: Our study indicates that MVPA positively influences TBLH BMC through pathways not related to free leptin index in predominantly normal-weight prepubertal children, likely primarily through mechanical loading. The relationships between MVPA, free leptin index and TBLH BMC may be influenced by other factors such as pubertal status and adiposity, so it is unknown whether these observations extend to overweight and obese children at different stages of puberty.

scholarly journals Effects of DHA-Rich n-3 Fatty Acid Supplementation and/or Resistance Training on Body Composition and Cardiometabolic Biomarkers in Overweight and Obese Post-Menopausal Women

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2465
Author(s):  
Elisa Félix-Soriano ◽  
Alejandro Martínez-Gayo ◽  
María José Cobo ◽  
Adriana Pérez-Chávez ◽  
Javier Ibáñez-Santos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Composition ◽  
Resistance Training ◽  
Glucose Tolerance ◽  
Bone Mineral Content ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Content ◽  
Lower Limbs ◽  
Pufa Supplementation

Resistance training (RT) and n-3 polyunsaturated fatty acids (n-3 PUFA) supplementation have emerged as strategies to improve muscle function in older adults. Overweight/obese postmenopausal women (55–70 years) were randomly allocated to one of four experimental groups, receiving placebo (olive oil) or docosahexaenoic acid (DHA)-rich n-3 PUFA supplementation alone or in combination with a supervised RT-program for 16 weeks. At baseline and at end of the trial, body composition, anthropometrical measures, blood pressure and serum glucose and lipid biomarkers were analyzed. Oral glucose tolerance tests (OGTT) and strength tests were also performed. All groups exhibit a similar moderate reduction in body weight and fat mass, but the RT-groups maintained bone mineral content, increased upper limbs lean mass, decreased lower limbs fat mass, and increased muscle strength and quality compared to untrained-groups. The RT-program also improved glucose tolerance (lowering the OGTT incremental area under the curve). The DHA-rich supplementation lowered diastolic blood pressure and circulating triglycerides and increased muscle quality in lower limbs. In conclusion, 16-week RT-program improved segmented body composition, bone mineral content, and glucose tolerance, while the DHA-rich supplement had beneficial effects on cardiovascular health markers in overweight/obese postmenopausal women. No synergistic effects were observed for DHA supplementation and RT-program combination.

scholarly journals Sodium loading, treadmill walking, and the acute redistribution of bone mineral content on dual energy X-ray absorptiometry scans

2019 ◽  
Vol 316 (1) ◽  
pp. R59-R67
Author(s):  
Tamara Hew-Butler ◽  
Kailyn Angelakos ◽  
Joshua Szczepanski
Keyword(s):  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Dual Energy ◽  
Treadmill Walking ◽  
Primary Study ◽  
Intervention Trial ◽  
Dxa Scan ◽  
X Ray ◽  
Total Body

The purpose of this study was to assess relationships between plasma sodium concentration ([Na+]) and bone mineral content (BMC) after an acute sodium load plus treadmill walking and then quantify the amount of sodium the dual energy X-ray absorptiometry (DXA) scan could detect. The primary study was a single-blind randomized control crossover trial under two conditions: ingestion of six flour tablets (placebo trial) or six 1-g NaCl tablets (salt intervention trial). The tablets were ingested after baseline blood and urine collection followed immediately by the DXA scan. After 60 min of rest, a 45-min treadmill walk was conducted. Immediately postexercise, blood and urine were collected and the DXA scan was repeated. Main outcomes included changes (∆: post minus pre) in plasma [Na+] and BMC. Additionally, six 1-g NaCl tablets were superimposed over a DXA spine phantom for separate quantification of sodium as BMC. Fourteen subjects completed the primary study. Two-way repeated measures ANOVA tests revealed significant interaction ( F = 13.06; P = 0.0007), condition ( F = 21.88; P < 0.001), and time ( F = 6.51; P = 0.014) effects in plasma [Na+]. A significant condition ( F = 6.46; P = 0.014) effect was also noted in urine [Na+]. Total body BMC∆ was negatively correlated with plasma [Na+]∆ ( r = −0.43; P = 0.02) and urine [Na+]∆ ( r = −0.47; P = 0.01). Total body BMC∆ in the salt intervention trial [−5.5 (27) g] closely approximated the amount of NaCl ingested and subsequently absorbed into the bloodstream. The DXA scan quantified 67% of NaCl tablets as BMC in spine phantom analyses. Total body BMC∆ was negatively related to plasma and urine [Na+]∆ after treadmill walking. Reductions in total body BMC closely approximated the amount of NaCl ingested (~6 g). The DXA scan quantified NaCl as BMC.

TOTAL BODY BONE MINERAL CONTENT AND DENSITY IN MALES AND FEMALES AGED 10???80 YEARS

1992 ◽  
Vol 24 (Supplement) ◽  
pp. S11 ◽  
Author(s):  
P. C. Fehling ◽  
R. J. Stillman ◽  
K. A. Boileau ◽  
M. H. Slaughter ◽  
J. L. Clasey ◽  
...  
Keyword(s):  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Males And Females ◽  
Total Body ◽  
Total Body Bone Mineral ◽  
Body Bone

Determinants of total-body and regional bone mineral content and density in postpubertal normal women

Metabolism ◽  
1994 ◽  
Vol 43 (2) ◽  
pp. 263-266 ◽  
Author(s):  
H. Rico ◽  
M. Revilla ◽  
L.F. Villa ◽  
M.Alvarez del Buergo ◽  
D. Ruiz-Contreras
Keyword(s):  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Normal Women ◽  
Total Body ◽  
Regional Bone Mineral Content

Does childhood and adolescence fracture influence bone mineral content in young adulthood?

2010 ◽  
Vol 35 (3) ◽  
pp. 235-243 ◽  
Author(s):  
Chantal E. Kawalilak ◽  
Adam D.G. Baxter-Jones ◽  
Robert A. Faulkner ◽  
Donald A. Bailey ◽  
Saija A. Kontulainen
Keyword(s):  
Physical Activity ◽  
Bone Mineral Content ◽  
Young Adulthood ◽  
Bone Mineral ◽  
Mineral Content ◽  
Bone Fragility ◽  
Primary Objective ◽  
Childhood And Adolescence ◽  
Pediatric Fracture ◽  
Total Body

Previous fracture may predispose an individual to bone fragility because of impaired bone mineral accrual. The primary objective of the study was to investigate the influence of fractures sustained during childhood and (or) adolescence on total body (TB), lumbar spine (LS), femoral neck (FN), and total hip (TH) bone mineral content (BMC) in young adulthood. It was hypothesized that there would be lower TB, LS, FN, and TH BMC in participants who had sustained a pediatric fracture. Participant anthropometrics, physical activity, and BMC (measured with dual energy X-ray absorptiometry) were assessed longitudinally during childhood and adolescence (from 1991 to 1997), and again in young adulthood (2002 to 2006). Sex, adult height, adult lean mass, adult physical activity, and adolescent BMC adjusted TB, LS, FN, and TH BMC in young adulthood, for those who reported 1 or more fractures (n = 42), were compared with those who reported no fractures (n = 101). There were no significant differences (p > 0.05) in adjusted BMC between fracture and nonfracture groups at the TB, LS, FN, and TH sites in young adulthood. These results suggest that fractures sustained during childhood and adolescence may not interfere with bone mass in young adulthood at clinically relevant bone sites.

scholarly journals Reduced bone mineral content and density in neurofibromatosis type 1 and its association with nutrient intake

2020 ◽  
Vol 66 (5) ◽  
pp. 666-672
Author(s):  
Marcio Leandro Ribeiro de Souza ◽  
Ann Kristine Jansen ◽  
Luiz Oswaldo Carneiro Rodrigues ◽  
Darlene Larissa de Souza Vilela ◽  
Adriana Maria Kakehasi ◽  
...  
Keyword(s):  
Food Intake ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Neurofibromatosis Type 1 ◽  
Nutrient Intake ◽  
Mineral Content ◽  
Neurofibromatosis Type ◽  
Bone Phenotype ◽  
Total Body

SUMMARY BACKGROUND Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease characterized by multisystem involvement including low bone mineral density (BMD). OBJECTIVE To assess the bone phenotype of individuals with NF1 and verify its association with nutrient intake. METHODS Twenty-six adults with NF1 underwent bone phenotype assessments using dual-energy X-ray absorptiometry (DXA) and food intake evaluations. They were compared to 26 unaffected matched control patients. Weight, height, and waist circumference (WC) were measured. DXA provided total body, spine, and hip BMDs and bone mineral content (BMC) for all patients. Food intake was evaluated for energy, macro- and micro-nutrients. RESULTS Height (1.68 ± 0.1; 1.61 ± 0.1 cm; P = 0.003) and BMC (2.3 ± 0.4; 2.0 ± 0.5 kg; P = 0.046) were lower in the NF1 group. Individuals with NF1 also presented lower total body and spine BMDs (g/cm2) (1.1 ± 0.1, 1.0 ± 0.1, P = 0.036; 1.0 ± 0.1, 0.9 ± 0.1; P = 0.015, respectively). The frequency of total body bone mass below the expected level for patients’ ages was higher in the NF1 group (7.7%; 34.6%, P = 0.016). There were no differences in energy consumption. No correlations between BMC and BMD with nutrient intake were observed in the NF1 group. CONCLUSIONS The NF1 group presented lower BMCs and BMDs. Although a lower consumption of calcium, iron, and vitamin A, and a higher intake of sodium and omega-6 were observed, there was no relationship between bone phenotype and nutrient intake.

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