Validation of Pulse Oximetry During Progressive Normobaric Hypoxia Utilizing a Portable Chamber

2004 ◽  
Vol 29 (1) ◽  
pp. 3-15 ◽  
Author(s):  
Jon C. Kolb ◽  
Peter Farran ◽  
Stephen R. Norris ◽  
David Smith ◽  
Joachim Mester

Validation of pulse oximetry in commercially available normobaric hypoxic chambers (NHC) has not been previously reported. The present study examined the validity of pulse oximetry (SpO2) against direct measurements of arterial oxygen saturation (SaO2) via co-oximetry (AVOXimeter 4000) in 13 young adults age 21.3 ± 0.6 years. Over a period of 2.5 hrs, the inspired fraction of oxygen inside a NHC (Hypoxico, Inc.) was progressively reduced from 20.9% to 11.5%. Measurements of SaO2 at baseline and at 15, 30, 60, 90, 120, and 150 min during the hypoxic exposures were compared with SpO2 estimates of oxygen saturation (Nellcor 295) using reflectance (RS-10, temporal) and transmission (D-25, finger) sensors. Regression analysis and methods for assessing agreement (bias, b; precision, p) of SaO2 with SpO2 were similar (R2 = 0.92, 0.89; b = 0.016, −0.47; p = 2.47, 3.03; RS-10 and D-25, respectively). When SaO2 < 85%, RS-10 had greater validity than D-25 (R2 = 0.73, 0.56; b = 1.38, 1.13; p = 2.72, 4.34; RS-10 and D-25, respectively). In light of these findings, caution should be exercised when monitoring individuals with pulse oximetry during desaturation episodes below 85%. When employing frequent NHC exposures, a priori validation of SpO2 utilized to assess blood oxygen status appears warranted. Key words: oxygen saturation, co-oximetry, altitude

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shinshu Katayama ◽  
Jun Shima ◽  
Ken Tonai ◽  
Kansuke Koyama ◽  
Shin Nunomiya

AbstractRecently, maintaining a certain oxygen saturation measured by pulse oximetry (SpO2) range in mechanically ventilated patients was recommended; attaching the INTELLiVENT-ASV to ventilators might be beneficial. We evaluated the SpO2 measurement accuracy of a Nihon Kohden and a Masimo monitor compared to actual arterial oxygen saturation (SaO2). SpO2 was simultaneously measured by a Nihon Kohden and Masimo monitor in patients consecutively admitted to a general intensive care unit and mechanically ventilated. Bland–Altman plots were used to compare measured SpO2 with actual SaO2. One hundred mechanically ventilated patients and 1497 arterial blood gas results were reviewed. Mean SaO2 values, Nihon Kohden SpO2 measurements, and Masimo SpO2 measurements were 95.7%, 96.4%, and 96.9%, respectively. The Nihon Kohden SpO2 measurements were less biased than Masimo measurements; their precision was not significantly different. Nihon Kohden and Masimo SpO2 measurements were not significantly different in the “SaO2 < 94%” group (P = 0.083). In the “94% ≤ SaO2 < 98%” and “SaO2 ≥ 98%” groups, there were significant differences between the Nihon Kohden and Masimo SpO2 measurements (P < 0.0001; P = 0.006; respectively). Therefore, when using automatically controlling oxygenation with INTELLiVENT-ASV in mechanically ventilated patients, the Nihon Kohden SpO2 sensor is preferable.Trial registration UMIN000027671. Registered 7 June 2017.


2008 ◽  
Vol 10 (03) ◽  
pp. 250-254 ◽  
Author(s):  
Andrew Harris ◽  
Michael Sendak ◽  
D. Chung ◽  
Charles Richardson

2016 ◽  
Vol 29 (5) ◽  
pp. 343
Author(s):  
Miguel Pinto da Costa ◽  
Henrique Pimenta Coelho

<p>The authors present a case of a 60-year-old male patient, previously diagnosed with B-cell chronic lymphocytic leukemia, who was admitted to the Emergency Room with dyspnea. The initial evaluation revealed severe anemia (Hgb = 5.0 g/dL) with hyperleukocytosis (800.000/µL), nearly all of the cells being mature lymphocytes, a normal chest X-ray and a low arterial oxygen saturation (89%; pulse oximetry). After red blood cell transfusion, Hgb values rose (9.0 g/dL) and there was a complete reversion of the dyspnea. Yet, subsequent arterial blood gas analysis, without the administration of supplemental oxygen, systematically revealed very low oxygen saturation values (~ 46%), which was inconsistent with the patient’s clinical state and his pulse oximetry values (~ 87%), and these values were not corrected by the administration of oxygen via non-rebreather mask. The investigation performed allowed to establish the diagnosis of oxygen leukocyte larceny, a phenomenon which conceals the true oxygen saturation due to peripheral consumption by leukocytes.</p>


1985 ◽  
Vol 64 (11) ◽  
pp. 1108???1112 ◽  
Author(s):  
I. L. Tyler ◽  
Boonrak Tantisira ◽  
Peter M. Winter ◽  
Etsuro K. Motoyama

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