Mouse genetic model for left-right hand usage: Context, direction, norms of reaction, and memory

Genome ◽  
1999 ◽  
Vol 42 (6) ◽  
pp. 1150-1166 ◽  
Author(s):  
Fred G Biddle ◽  
Brenda A Eales
Keyword(s):  
Genetic Model ◽  
Quantitative Difference ◽  
Laboratory Mouse ◽  
Qualitative Difference ◽  
Test Chamber ◽  
Inbred Strains ◽  
The Difference ◽  
Left Right Asymmetry ◽  
Conditioned Behaviour ◽  
The Right

Asymmetry of paw usage in the laboratory mouse is an experimental model for left-right asymmetry of hand usage. Given a set number of reaches into a centrally placed food tube (an unbiased or U-world test), individual mice exhibit a number of left and right paw reaches that is reliably expressed on retesting. Whereas different inbred strains appear to have equal numbers of individual mice with a left- or a right-preferred paw after a U-world test, there are significant differences among strains in the degree or strength of lateralization of the preferred paw. We report here a systematic series of tests of paw usage with naive mice and retests of the individuals in test chambers with the food tube biased to the left or to the right, contrasting the highly lateralized C57BL/6J and the very weakly lateralized (or ambilateral) CDS/Lay inbred strains and their (B6 × CDS) F1 generation. The results caused a shift in the paradigm of paw usage. There is an unexpected qualitative difference in paw usage between C57BL/6J and CDS/Lay. C57BL/6J is random in its left-right paw usage, but it is conditioned by the left or right direction of the initial biased-world test and by usage. CDS/Lay is constitutively equal-pawed, responds very little to direction of the test chamber, and is not conditioned by it. The probability of left-paw versus right-paw usage depends on both the genotype and the context of the test. The (B6 × CDS) F1 generation suggests that constitutive equal-paw usage of CDS/Lay is dominant to experience-conditioned paw usage of C57BL/6J. There is also an apparent quantitative difference between the very weakly lateralized (ambilateral) preferred paw usage in CDS/Lay and the highly lateralized preferred paw usage in C57BL/6J. The difference in degree of lateralization of preferred paw usage between the constitutively equal-pawed CDS/Lay strain and (B6 × CDS) F1 generation must originate from allelic differences at other gene loci between the CDS/Lay and C57BL/6J parental strains. The SWV and NOD/Lt strains were also assessed in asymmetrical tests because they were known to be weakly lateralized and similar to each other in a U-world test and to be significantly different from both C57BL/6J and CDS/Lay. SWV is experience-conditioned and weakly lateralized; NOD/Lt is constitutively equal-pawed and weakly lateralized. Further analysis will determine the genetic cause of the qualitative difference between constitutive equal-paw and experience-conditioned paw usage and the genetic cause of the quantitative differences in degree of lateralization of the preferred paw within each type of paw usage.Key words: mouse, left-right handedness, behavioural genetics, phenotypic reaction norms, constitutive behaviour, experience-conditioned behaviour, memory.

Lateral asymmetry of paw usage: phenotypic survey of constitutive and experience-conditioned paw-usage behaviours among common strains of the mouse

Genome ◽  
2001 ◽  
Vol 44 (4) ◽  
pp. 539-548 ◽  
Author(s):  
Fred G Biddle ◽  
Brenda A Eales
Keyword(s):  
Quantitative Difference ◽  
Qualitative Difference ◽  
Test Chamber ◽  
Test Sequence ◽  
Lateral Asymmetry ◽  
Left And Right ◽  
The Difference ◽  
Different Strains ◽  
Conditioned Behaviour ◽  
The Right

Left-right direction of paw usage in the mouse is defined by the right-paw entry (RPE) score, which is the number of reaches with the right paw to retrieve food from a small food tube in a total of 50 right- and left-paw reaches. Two qualitatively different paw-usage behaviours can be identified by the difference in the RPE scores from naive mice in left- or right-biased test chambers and their retest, 1 week later, in the opposite-biased test chamber. In mice with constitutive paw usage, the RPE score may respond to the direction of a biased test chamber, but it returns to the value that is expected for naive mice in the opposite-biased test chamber. In mice with experience-conditioned paw usage, the RPE score responds to the direction of a biased test chamber and does not return to its expected value in the opposite-biased test chamber. In this report, we document the alternate paw usage behaviours in an extended phenotypic survey of different strains that will be useful for its genetic analysis. We also validate an alternate biometrical method to identify constitutive and experience-conditioned paw usage that is based on the mean average RPE score from the biased test and opposite-biased retest of individual mice. This alternate biometrical method demonstrated that, in some strains with experience-conditioned paw usage, there may be asymmetry or an interaction between genotype and the direction of the test sequence. In addition, the strain survey demonstrated that the qualitative difference between constitutive and experience-conditioned paw usage is independent of the well-known quantitative difference in the degree of lateralization of preferred-paw usage.Key words: mouse, lateral asymmetry of paw usage, left and right handedness, behavioural genetics, constitutive behaviour, experience-conditioned behaviour.

A two-locus model for experience-conditioned direction of paw usage in the mouse is suggested by dominant and recessive constitutive paw usage behaviours

Genome ◽  
2001 ◽  
Vol 44 (5) ◽  
pp. 872-882 ◽  
Author(s):  
Fred G Biddle ◽  
Danielle A Jones ◽  
Brenda A Eales
Keyword(s):  
Test Chamber ◽  
Functional Difference ◽  
Constitutive Behaviour ◽  
Loss Of Function ◽  
Phenotypic Analysis ◽  
Locus Heterogeneity ◽  
Locus Model ◽  
Left Right Asymmetry ◽  
Conditioned Behaviour ◽  
Behaviour Learning

Left-right direction of paw usage in the mouse depends on the genotype and the directional nature of the test. There are two phenotypic classes; in some strains, direction of paw usage is learned or conditioned by the direction of the initial test chamber and the experience of reaching and, in other strains, paw usage is a constitutive behaviour not affected by previous experience. We report the evidence for locus heterogeneity in the cause of constitutive versus experience-conditioned paw usage from a phenotypic analysis of F1 hybrid generations from the experience-conditioned C57BL/6J, C3H/HeHa, and SWV strains and the constitutive CDS/Lay and DBA/2J strains. The F1 hybrids between strains of different phenotypic classes provide evidence of locus heterogeneity. Constitutive paw usage in CDS/Lay is phenotypically dominant to experience-conditioned behaviour in both C57BL/6J and SWV. However, constitutive paw usage in DBA/2J is phenotypically recessive to experience-conditioned behaviour in C57BL/6J and dominant to experience-conditioned behaviour in SWV. Among the experience-conditioned strains, C57BL/6J is highly lateralized but SWV is only weakly lateralized. Our data suggest a model in which C57BL/6J may have a "strong" allele that identifies a functional difference between the constitutive paw usage of CDS/Lay and DBA/2J. DBA/2J may have a loss-of-function mutation at the same locus that is recessive to the strong C57BL/6J allele. SWV may have a "weak" allele and the (SWV × D2)F1 compound heterozygote may be below a threshold for detectability of experience-conditioned behaviour, making the constitutive behaviour of DBA/2J appear to be dominant to the experience-conditioned behaviour of SWV. CDS/Lay may have a dominant allele at a second locus that suppresses experience-conditioned behaviour in all F1 hybrids.Key words: mouse, left-right asymmetry of hand usage, behavioural genetics, experience-conditioned behaviour, dominant and recessive constitutive behaviour, learning, memory.

Legal Update: North Dakota Supreme Court: Third Edition of Guides is “Most Current”

1999 ◽  
Vol 4 (1) ◽  
pp. 6-7
Author(s):  
James J. Mangraviti
Keyword(s):  
Internal Rotation ◽  
External Rotation ◽  
Measurement Techniques ◽  
Fourth Edition ◽  
Hip Motion ◽  
The Difference ◽  
The Right ◽  
Hip Flexion ◽  
Hip Rotation ◽  
Hip Extension

Abstract The accurate measurement of hip motion is critical when one rates impairments of this joint, makes an initial diagnosis, assesses progression over time, and evaluates treatment outcome. The hip permits all motions typical of a ball-and-socket joint. The hip sacrifices some motion but gains stability and strength. Figures 52 to 54 in AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), Fourth Edition, illustrate techniques for measuring hip flexion, loss of extension, abduction, adduction, and external and internal rotation. Figure 53 in the AMA Guides, Fourth Edition, illustrates neutral, abducted, and adducted positions of the hip and proper alignment of the goniometer arms, and Figure 52 illustrates use of a goniometer to measure flexion of the right hip. In terms of impairment rating, hip extension (at least any beyond neutral) is irrelevant, and the AMA Guides contains no figures describing its measurement. Figure 54, Measuring Internal and External Hip Rotation, demonstrates proper positioning and measurement techniques for rotary movements of this joint. The difference between measured and actual hip rotation probably is minimal and is irrelevant for impairment rating. The normal internal rotation varies from 30° to 40°, and the external rotation ranges from 40° to 60°.

Implementasi Sistem Informasi Monitoring Pengolahan Data Inventory Gudang Pada PT.Talaga Mulya Indah

2020 ◽  
Vol 6 (2) ◽  
pp. 187-197
Author(s):  
Nurlaila Suci Rahayu Rais ◽  
Dedeh Apriyani ◽  
Gito Gardjito
Keyword(s):  
Data Processing ◽  
Integrated Control ◽  
Unified Modeling Language ◽  
Review Literature ◽  
Analysis Method ◽  
Inventory Data ◽  
Literature Study ◽  
Unified Modeling ◽  
The Difference ◽  
The Right

Monitoring of warehouse inventory data processing is an important thing for companies. PT Talaga mulya indah is still manual using paper media, causing problems that have an effect on existing information, namely: problems with data processing of incoming and outgoing goods. And the difference between data on the amount of stock of goods available with physical data, often occurs inputting data more than once for the same item, searching for available data, and making reports so that it impedes companies in monitoring inventory of existing stock of goods. Which aims to create a system that can provide updated information to facilitate the warehouse admin in making inventory reports, and reduce errors in input by means of integrated control. In this study, the authors used the data collection method used in this analysis using the method of observation, interviews, and literature review (literature study). For analysis using the PIECES analysis method. Furthermore, the system design used is UML (Unified Modeling Language). The results of this study are expected to produce the right data in the process of monitoring inventory data processing, also can provide the right information and make it easier to control the overall availability of goods.

Konsep Pemerintahan Religius dan Demokrasi Menurut Abdul Karim Soroush dan Ayatullah Khomeini

2013 ◽  
Vol 3 (2) ◽  
pp. 438-473
Author(s):  
M. Heri Fadoil
Keyword(s):  
Religious System ◽  
Islamic Jurisprudence ◽  
Ayatollah Khomeini ◽  
The Difference ◽  
The Government ◽  
The Right

Abstract: Abdul Karim Soroush judges that religious rule is incorrect assessment of the application of Islamic jurisprudence. In a religious society, Islamic jurisprudence obtains the right to govern. It is, of course, necessary to establish a kind of Islamic jurisprudence-based religious rule. Soroush firmly rejects it because such interpretation is too narrow. As for democracy, Soroush argues that the system used is not necessarily equal to that of the Western. On the contrary, Ayatollah Khomeini’s thoughts on religious rule are reflected in the so called wilayat al-faqih. It is a religious scholar-based government. Democracy, according to him, is the values of Islam itself, which is able to represent the level of a system to bring to the country’s progress. Principally, there are some similarities between the ideas of Ayatollah Khomeini and those of Abdul Karim Soroush in term of religiosity. They assume that it is able to sustain the religious system of government. The difference between both lies on the application of religiosity itself. Ayatollah Khomeini applies the concept of a religious scholar-based government, while Abdul Karim Soroush rejects the institutionalization of religion in the government or state.Keywords: Governance, democracy, Abdul Karim Soroush, Ayatollah Khomeini

Our Bodies, Whose Property?

2013 ◽  
Author(s):  
Anne Phillips
Keyword(s):  
Labor Markets ◽  
Personal Autonomy ◽  
The Body ◽  
Body Parts ◽  
Complex Issue ◽  
Human Organs ◽  
Property Owners ◽  
The Common ◽  
The Difference ◽  
The Right

No one wants to be treated like an object, regarded as an item of property, or put up for sale. Yet many people frame personal autonomy in terms of self-ownership, representing themselves as property owners with the right to do as they wish with their bodies. Others do not use the language of property, but are similarly insistent on the rights of free individuals to decide for themselves whether to engage in commercial transactions for sex, reproduction, or organ sales. Drawing on analyses of rape, surrogacy, and markets in human organs, this book challenges notions of freedom based on ownership of our bodies and argues against the normalization of markets in bodily services and parts. The book explores the risks associated with metaphors of property and the reasons why the commodification of the body remains problematic. The book asks what is wrong with thinking of oneself as the owner of one's body? What is wrong with making our bodies available for rent or sale? What, if anything, is the difference between markets in sex, reproduction, or human body parts, and the other markets we commonly applaud? The book contends that body markets occupy the outer edges of a continuum that is, in some way, a feature of all labor markets. But it also emphasizes that we all have bodies, and considers the implications of this otherwise banal fact for equality. Bodies remind us of shared vulnerability, alerting us to the common experience of living as embodied beings in the same world. Examining the complex issue of body exceptionalism, the book demonstrates that treating the body as property makes human equality harder to comprehend.

scholarly journals Sacrificing Oneself or Another: The Difference Between Prescriptive and Normative Judgments in Moral Evaluation

2020 ◽  
pp. 003329411989606
Author(s):  
Štěpán Bahník ◽  
Emir Efendic ◽  
Marek A. Vranka
Keyword(s):  
Moral Judgment ◽  
Moral Evaluation ◽  
Normative Judgment ◽  
Question Wording ◽  
Judgment Type ◽  
Course Of Action ◽  
The Difference ◽  
The Right ◽  
The Sacrifice ◽  
Normative Judgments

When asked whether to sacrifice oneself or another person to save others, one might think that people would consider sacrificing themselves rather than someone else as the right and appropriate course of action—thus showing an other-serving bias. So far however, most studies found instances of a self-serving bias—people say they would rather sacrifice others. In three experiments using trolley-like dilemmas, we tested whether an other-serving bias might appear as a function of judgment type. That is, participants were asked to make a prescriptive judgment (whether the described action should or should not be done) or a normative judgment (whether the action is right or wrong). We found that participants exhibited an other-serving bias only when asked whether self- or other-sacrifice is wrong. That is, when the judgment was normative and in a negative frame (in contrast to the positive frame asking whether the sacrifice is right). Otherwise, participants tended to exhibit a self-serving bias; that is, they approved sacrificing others more. The results underscore the importance of question wording and suggest that some effects on moral judgment might depend on the type of judgment.

scholarly journals Changes in Children’s Body Composition and Posture during Puberty Growth

Children ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 288
Author(s):  
Wojciech Rusek ◽  
Joanna Baran ◽  
Justyna Leszczak ◽  
Marzena Adamczyk ◽  
Rafał Baran ◽  
...  
Keyword(s):  
Body Composition ◽  
Adipose Tissue ◽  
Regression Analysis ◽  
Body Mass ◽  
Pelvic Obliquity ◽  
The Body ◽  
Body Posture ◽  
Older Children ◽  
The Difference ◽  
The Right

The main goal of our study was to determine how the age of children, puberty and anthropometric parameters affect the formation of body composition and faulty body posture development in children. The secondary goal was to determine in which body segments abnormalities most often occur and how gender differentiates the occurrence of adverse changes in children’s body posture and body composition during puberty. The study group consisted of 464 schoolchildren aged from 6–16. Body posture was assessed with the Zebris system. The composition of the body mass was tested with Tanita MC 780 MA body mass analyzer and the body height was measured using a portable stadiometer PORTSTAND 210. The participants were further divided due to the age of puberty. Tanner division was adopted. The cut-off age for girls is ≥10 years and for boys it is ≥12 years. The analyses applied descriptive statistics, the Pearson correlation, stepwise regression analysis and the t-test. The accepted level of significance was p < 0.05. The pelvic obliquity was lower in older children (beta = −0.15). We also see that age played a significant role in the difference in the height of the right pelvis (beta = −0.28), and the difference in the height of the right shoulder (beta = 0.23). Regression analysis showed that the content of adipose tissue (FAT%) increased with body mass index (BMI) and decreased with increasing weight, age, and height. Moreover, the FAT% was lower in boys than in girls (beta negative equal to −0.39). It turned out that older children (puberty), had greater asymmetry in the right shoulder blade (p < 0.001) and right shoulder (p = 0.003). On the other hand, younger children (who were still before puberty) had greater anomalies in the left trunk inclination (p = 0.048) as well as in the pelvic obliquity (p = 0.008). Girls in puberty were characterized by greater asymmetry on the right side, including the shoulders (p = 0.001), the scapula (p = 0.001) and the pelvis (p < 0.001). In boys, the problem related only to the asymmetry of the shoulder blades (p < 0.001). Girls were characterized by a greater increase in adipose tissue and boys by muscle tissue. Significant differences also appeared in the body posture of the examined children. Greater asymmetry within scapulas and shoulders were seen in children during puberty. Therefore, a growing child should be closely monitored to protect them from the adverse consequences of poor posture or excessive accumulation of adipose tissue in the body.

scholarly journals Elderly’s preferences towards rehabilitation robot appearance using electroencephalogram signal

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Xinxin Sun ◽  
Wenkui Jin
Keyword(s):  
Assisted Living ◽  
The Elderly ◽  
Rehabilitation Robots ◽  
Subjective Evaluations ◽  
Analysis Experiment ◽  
Prefrontal Region ◽  
Important Means ◽  
The Difference ◽  
Robot Appearance ◽  
The Right

AbstractRehabilitation robots are becoming an important means of assisted living for the elderly, and the appearance of rehabilitation robots directly affects the willingness of the elderly to interact with the robots. Much of the current research on robot appearance preferences relies solely on subjective evaluations, which are relatively cheap, but do not reach deep into the brain to get an accurate grasp of how humans respond to robot appearance. Using electroencephalogram signal and questionnaire survey, we studied the preference of the elderly for abstract and figurative robots. The experimental materials are derived from the pictures of 10 robots in the market. The electroencephalogram signal are collected by BrainVision Recorder and processed by BrainVision Analyzer, as well as SPSS statistical analysis. Experiment shows that the peak of figurative robot pictures is higher and the fluctuation is more intense from 350 ms to 600 ms in the central region and the right half of parietal region. While the peak of abstract robot pictures is higher and the fluctuation is more intense in the prefrontal region, and the difference between abstract robot and figurative robot is not obvious in the occipital region. Based on the electroencephalogram signal and experimental results, it provides the possibility for objective preference evaluation of the elderly to the robot designed features.

scholarly journals EVIDENCE THAT TWO LOCI PREDOMINANTLY DETERMINE THE DIFFERENCE IN SUSCEPTIBILITY TO THE HIGH PRESSURE NEUROLOGIC SYNDROME TYPE I SEIZURE IN MICE

Genetics ◽  
1981 ◽  
Vol 99 (2) ◽  
pp. 285-307
Author(s):  
R D McCall ◽  
D Frierson
Keyword(s):  
High Pressure ◽  
Inbred Mouse ◽  
Inbred Strains ◽  
Chromosome 17 ◽  
Seizure Threshold ◽  
Mouse Strains ◽  
Compression Rate ◽  
Type I ◽  
Major Locus ◽  
The Difference

ABSTRACT Most mammals tested, when exposed to increasing pressure in helium/oxygen atmospheres, exhibit progressive motor disturbances culminating in two, usually successive, well-differentiated convulsive seizures. The seizures are highly reproducible components of the constellation of events that collectively constitute the High Pressure Neurologic Syndrome (HPNS). In the present study, we present evidence that the mean difference in seizure threshold pressures of the first seizure to occur (HPNS Type I) between inbred mouse strains DBA/2J and C57BL/6J is predominantly determined (&gt; 60%) by the expression of a major locus—possibly linked to the H-2 locus on chromosome 17—and a minor locus, probably unlinked. This outcome is derived from applications of the maximum likelihood modeling procedure of Elston and Stewart (1973) and Stewart and Elston (1973) to eleven models of genetic determinacy and tests (including breeding tests) of "preferred" models so derived using BXD recombinant inbred strains that show the following: The major locus exhibits conditional dominance characteristics depending upon compression rate and minor locus genotype. At a constant mean compression rate of 100 atm hr-1, the major locus manifests strong, though incomplete, dominance apparently independent of minor locus genotype. Its expression is, however, highly sensitive to compression rate, losing its dominance altogether at a linear rate of 1,000 atm hr-1. The major locus interacts with the weakly dominant and relatively compression-rate-insensitive minor locus to retain dominance at fast compression only when the dominant alleles of both loci are present. A principal finding of this study is that employing two compression rates permits fuller genetic characterization of murine high-pressure seizure susceptibility differences than could be achieved by use of a single compression rate.

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