Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31)

Genome ◽  
1999 ◽  
Vol 42 (5) ◽  
pp. 1030-1032 ◽  
Author(s):  
Achim D Gruber ◽  
Bendicht U Pauli
Keyword(s):  
Gene Family ◽  
Radiation Hybrid ◽  
Chloride Channels ◽  
Mammalian Species ◽  
Expression Patterns ◽  
Family Members ◽  
Radiation Hybrid Mapping ◽  
Chromosome 1 ◽  
Hybrid Mapping ◽  
Specific Expression

The CLCA gene family is a novel family of calcium-activated chloride channels. Several family members have recently been cloned from different mammalian species with distinct, highly tissue-specific expression patterns. Here, we describe radiation hybrid mapping of the human CLCA2 and CLCA3 genes using the Genebridge 4 panel. Both genes were mapped to adjacent loci on the short arm of chromosome 1 (1p22-31), a region to which the human CLCA1 had been assigned earlier. The results show clustering of all human CLCA family members known so far despite their moderately low levels of sequence homology and their heterogeneous expression patterns.Key words: radiation hybrid mapping, human chromosome 1p22-31, calcium-activated chloride channels.

Linkage and radiation hybrid mapping of the porcine IGF1R and TPM2 genes to chromosome 1

2002 ◽  
Vol 33 (5) ◽  
pp. 398-400 ◽  
Author(s):  
M. Kopečný ◽  
A. Stratil ◽  
H. Bartenschlager ◽  
L. J. Peelman ◽  
M. Van Poucke ◽  
...  
Keyword(s):  
Radiation Hybrid ◽  
Radiation Hybrid Mapping ◽  
Chromosome 1 ◽  
Hybrid Mapping

Assignment of 12 genes to porcine chromosome 1 by linkage and radiation hybrid mapping

2005 ◽  
Vol 0 (0) ◽  
pp. 051006062228007-???
Author(s):  
D. Nonneman ◽  
T. P. L. Smith ◽  
B. A. Freking ◽  
G. A. Rohrer
Keyword(s):  
Radiation Hybrid ◽  
Radiation Hybrid Mapping ◽  
Chromosome 1 ◽  
Hybrid Mapping ◽  
Porcine Chromosome

Radiation hybrid mapping of two members of the Toll-like receptor gene family in pigs

2004 ◽  
Vol 35 (3) ◽  
pp. 251-252 ◽  
Author(s):  
A. Franceschi ◽  
P. Cassini ◽  
D. Scalabrini ◽  
S. Botti ◽  
C.M. Bandi ◽  
...  
Keyword(s):  
Gene Family ◽  
Radiation Hybrid ◽  
Receptor Gene ◽  
Radiation Hybrid Mapping ◽  
Toll Like Receptor ◽  
Hybrid Mapping ◽  
Receptor Gene Family

scholarly journals Evolution and regulation of a large effector family of Pyricularia oryzae

2020 ◽  
Author(s):  
Daniel J Ebbole ◽  
Meilian Chen ◽  
Zhenhui Zhong ◽  
Nicholas Farmer ◽  
Wenhui Zheng ◽  
...  
Keyword(s):  
Gene Family ◽  
Expression Patterns ◽  
Family Members ◽  
Allelic Diversity ◽  
Sequence Divergence ◽  
Pyricularia Oryzae ◽  
Sequence Diversity ◽  
Null Alleles ◽  
In Planta ◽  
Specific Expression

Plant pathogen effectors play important roles in parasitism, including countering plant immunity. However, investigations of the emergence and diversification of fungal effectors across host-adapted populations has been limited. We previously identified a gene encoding a suppressor of plant cell death in Pyricularia oryzae (Syn. Magnaporthe oryzae). Here we report the gene is one of a 21-member gene family and we characterize sequence diversity in different populations. Within the rice pathogen population, nucleotide diversity is low, however, the majority of gene family members display presence-absence polymorphism or other null alleles. Gene family allelic diversity is greater between host-adapted populations and we thus named them host adapted genes (HAGs). Multiple copies of HAGs were found in some genome assemblies and sequence divergence between the alleles in two cases suggested they were the result of repeat-induced point mutagenesis. Transfer of family members between populations and novel HAG haplotypes resulting from apparent recombination were observed. HAG family transcripts were induced in planta and a subset of HAGs are dependent on a key regulator of pathogenesis, PMK1. We also found differential intron splicing for some HAGs that would prevent ex planta protein expression. For some genes, spliced transcript was expressed in anti-phase with an overlapping antisense transcript. Characterization of HAG expression patterns and allelic diversity reveal novel mechanisms for HAG regulation and mechanisms generating sequence diversity and novel allele combinations. This evidence of strong in planta-specific expression and selection operating on the HAG family is suggestive of a role in parasitism.

scholarly journals Wide-Cross Whole-Genome Radiation Hybrid Mapping of Cotton (Gossypium hirsutumL.)

Genetics ◽  
2004 ◽  
Vol 167 (3) ◽  
pp. 1317-1329 ◽  
Author(s):  
Wenxiang Gao ◽  
Z. Jeffrey Chen ◽  
John Z. Yu ◽  
Dwaine Raska ◽  
Russell J. Kohel ◽  
...  
Keyword(s):  
Radiation Hybrid ◽  
Radiation Hybrid Mapping ◽  
Whole Genome ◽  
Hybrid Mapping ◽  
Wide Cross
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