THE LOCATION OF A RECESSIVE GENE FOR CHLOROPHYLL DEFICIENCY IN DIPLOID SOLANUM TUBEROSUM BY MEANS OF TRISOMIC ANALYSIS

1973 ◽  
Vol 15 (4) ◽  
pp. 807-813 ◽  
Author(s):  
J. G. Th. Hermsen ◽  
M. S. Ramanna ◽  
J. Vogel
Keyword(s):  
Solanum Tuberosum ◽  
Extra Chromosome ◽  
Recessive Gene ◽  
Mutant Gene ◽  
Trisomic Analysis ◽  
Recessive Mutant ◽  
Group B ◽  
Anthocyanin Production ◽  
Light Green ◽  
Aneuploid Analysis

A light green monogenic recessive mutant was found in diploid Solanum tuberosum. The mutant gene (v) was located by aneuploid analysis on the extra chromosome of a trisomic (2n = 25) derived parthenogenetically from cv. Intenso (2n = 48). The extra chromosome was identified at pachytene stage as chromosome XII according to the numbering system of Yeh and Peloquin (1965). The mutant gene appeared to be genetically independent of the linkage group B-I-F-Ow for anthocyanin distribution and of the gene P for anthocyanin production.

scholarly journals A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse.

1990 ◽  
Vol 171 (2) ◽  
pp. 519-531 ◽  
Author(s):  
A Matsuzawa ◽  
T Moriyama ◽  
T Kaneko ◽  
M Tanaka ◽  
M Kimura ◽  
...  
Keyword(s):  
Recessive Gene ◽  
Mutant Gene ◽  
Inbred Strains ◽  
Lymphoid Hyperplasia ◽  
Lymphoid Cells ◽  
Autoantibody Production ◽  
Genetic Studies ◽  
Inbred Strains Of Mice ◽  
Backcross Populations ◽  
Generalized Lymphadenopathy

Several mice with generalized lymphadenopathy were found in the CBA/KlJms (CBA) colony maintained at our institute. A new mutant strain of mice that develop massive lymphoid hyperplasia at 100% incidence within 5 mo after birth was established by crossing these diseased mice. Genetic studies on lymphadenopathy were conducted in F1, F2, and backcross populations from crosses between mutant CBA (CBA-m) and various inbred strains of mice. The results supported the control of lymphadenopathy by a single autosomal recessive gene. Since C3H/He-gld/gld (C3H-gld), MRL/MpJ-lpr/lpr (MRL-lpr), and C3H/HeJ-lpr/lpr (C3H-lpr) mice develop the same type of lymphoid hyperplasia, allelism of the mutant gene with gld or lpr was tested by investigating lymphadenopathy in F1 and backcross populations from crosses between CBA-m and C3H-gld, MRL-lpr, or C3H-lpr mice. The gene was confirmed to be allelic with lpr but not with gld. Interestingly, however, the mutant gene interacted with gld to induce less severe lymphadenopathy. Thus, the mutant gene was named lprcg, an lpr gene complementing gld in induction of lymphoproliferation. The genetic conclusion was supported by the same profile of surface markers of lymphoid cells with gld/gld, lpr/lpr, lprcg/lprcg, lprcg/lpr, and +/gld +/lprcg genotypes, as well as by massive lymph node hyperplasia and high titers of autoantibodies in the first four genotypes, but slight hyperplasia and insignificant autoantibody production in the last. The discovery of lprcg provided strong genetic evidence for the parallels between anomalous phenotypes of gld and lpr, and CBA/KlJms-lprcg/lprcg mice will contribute to elucidation of the mechanism of induction of the same abnormal differentiation and functions of lymphocytes by gld and lpr.

Cartilage anomaly (can); a new mutant gene in the mouse

Development ◽  
1971 ◽  
Vol 25 (1) ◽  
pp. 21-31
Author(s):  
D. R. Johnson ◽  
Jean M. Wise
Keyword(s):  
Electron Microscopy ◽  
Light Microscopy ◽  
Recessive Gene ◽  
Mutant Gene ◽  
Cartilaginous Matrix ◽  
The Matrix

Cartilage anomaly (symbol can) is a recessive gene in the mouse producing achondroplasia. Abnormal mice die at about 10 days after birth. Light microscopy reveals a systemic deficiency in the cartilaginous matrix. Electron microscopy suggests that the collagen of the matrix is normal and that the mucopolysaccharide component is reduced.

The presence of synaptic and chromosome disjunction mutants in Cenchrus ciliaris (Poaceae: Paniceae)

Bothalia ◽  
1999 ◽  
Vol 29 (2) ◽  
pp. 327-334 ◽  
Author(s):  
N. C. Visser ◽  
J. J. Spies ◽  
H. J. T. Venter
Keyword(s):  
Environmental Factors ◽  
Geographical Distribution ◽  
High Temperatures ◽  
Chromosome Abnormality ◽  
Mutant Gene ◽  
Cenchrus Ciliaris ◽  
High Incidence ◽  
Low Humidity ◽  
Recessive Mutant ◽  
Chromosome Disjunction

Synaptic mutants are present in  Cenchrus ciliaris L This species, due to the presence of linear bivalents and occasion­al trivalents and quadrivalents, is an intermediate desynaptic species. In addition, geographical distribution and environmental factors, such as high temperatures and low humidity, could also have had an influence on the desynapsis observed.The disjunction of chromosomes during anaphase I was mostly abnormal in this desynaptic species. Precocious disjunction of chromosomes into chromatids occurred during anaphase I Due to the high incidence of this chromosome abnormality, a mutant gene,  'pc'  responsible for the disjunction of chromosomes, must be present. The absence of cytokinesis in one specimen indicates a recessive mutant gene,  'va' to be active in this species.

scholarly journals Adult Patients With De Novo Acute Myeloid Leukemia and t(9; 11)(p22; q23) Have a Superior Outcome to Patients With Other Translocations Involving Band 11q23: A Cancer and Leukemia Group B Study

Blood ◽  
1997 ◽  
Vol 90 (11) ◽  
pp. 4532-4538 ◽  
Author(s):  
Krzysztof Mrózek ◽  
Kristiina Heinonen ◽  
David Lawrence ◽  
Andrew J. Carroll ◽  
Prasad R.K. Koduru ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
De Novo ◽  
Extra Chromosome ◽  
Response To Therapy ◽  
High Dose ◽  
Postremission Therapy ◽  
De Novo Aml ◽  
Group B ◽  
Acute Myeloid

Abstract Following reports of childhood acute myeloid leukemia (AML) showing that patients with t(9; 11)(p22; q23) have a better prognosis than those with translocations between 11q23 and other chromosomes, we compared response to therapy and survival of 24 adult de novo AML patients with t(9; 11) with those of 23 patients with other 11q23 translocations [t(11q23)]. Apart from a higher proportion of French-American-British (FAB) M5 subtype in the t(9; 11) group (83% v 43%, P = .006), the patients with t(9; 11) did not differ significantly from patients with t(11q23) in terms of their presenting clinical or hematologic features. Patients with t(9; 11) more frequently had an extra chromosome(s) 8 or 8q as secondary abnormalities (46% v 9%, P = .008). All patients received standard cytarabine and daunorubicin induction therapy, and most of them also received cytarabine-based intensification treatment. Two patients, both with t(9; 11), underwent bone marrow transplantation (BMT) in first complete remission (CR). Nineteen patients (79%) with t(9; 11) and 13 (57%) with t(11q23) achieved a CR (P = .13). The clinical outcome of patients with t(9; 11) was significantly better: the median CR duration was 10.7 versus 8.9 months (P = .02), median event-free survival was 6.2 versus 2.2 months (P = .009), and median survival was 13.2 versus 7.7 months (P = .009). All patients with t(11q23) have died, whereas seven (29%) patients with t(9; 11) remain alive in first CR. Seven of eight patients with t(9; 11) who received postremission regimens with cytarabine at a dose of 100 (four patients) or 400 mg/m2 (2 patients) or who did not receive postremission therapy (2 patients) have relapsed. In contrast, 7 (64%) of 11 patients who received intensive postremission chemotherapy with high-dose cytarabine (at a dose 3 g/m2) (5 patients), or underwent BMT (2 patients) remain in continuous CR. We conclude that the outcome of adults with de novo AML and t(9; 11) is more favorable than that of adults with other 11q23 translocations; this is especially true for t(9; 11) patients who receive intensive postremission therapy.

Rapid mapping of a chlorina mutant gene cn-A1 in hexaploid wheat by bulked segregant analysis and single nucleotide polymorphism genotyping arrays

2019 ◽  
Vol 70 (10) ◽  
pp. 827 ◽  
Author(s):  
H. B. Jiang ◽  
N. Wang ◽  
J. T. Jian ◽  
C. S. Wang ◽  
Y. Z. Xie
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Single Nucleotide Polymorphism Array ◽  
Bulked Segregant Analysis ◽  
Recessive Gene ◽  
Mutant Gene ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Chlorophyll Metabolism ◽  
Specific Pcr ◽  
Leaf Mutant

The yellow–green leaf mutant can be exploited in photosynthesis and plant development research. A Triticum aestivum mutant with the chlorina phenotype, here called B23, was produced by treatment with the chemical mutagen sodium azide. This B23 mutant showed significantly lower chlorophyll content than wild-type Saannong33, and its chloroplast structure was abnormal. All its yield-related traits, except for the number of spikes per plant, were also significantly decreased. Genetic analysis confirmed that the mutant phenotype was controlled by a recessive gene, here designated cn-A1. Using bulked segregant analysis and the wheat 660K single nucleotide polymorphism array, the cn-A1 gene was mapped to chromosome 7AL, and 11 polymorphic markers were developed. Further analysis showed that cn-A1 was located in a 1.1-cM genetic region flanked by Kompetitive allele specific PCR (KASP) markers 660K-7A12 and 660K-7A20, which corresponded to a physical interval of 3.48 Mb in T. aestivum cv. Chinese Spring chromosome 7AL containing 47 predicted genes with high confidence. These results are expected to accelerate the process of cloning the cn-A1 gene and facilitate understanding of the mechanisms underlying chlorophyll metabolism and chloroplast development in wheat.

scholarly journals Qualitative Inheritance of External Fruit Traits in Watermelon

HortScience ◽  
2016 ◽  
Vol 51 (5) ◽  
pp. 487-496 ◽  
Author(s):  
Lingli Lou ◽  
Todd C. Wehner
Keyword(s):  
Citrullus Lanatus ◽  
Recessive Gene ◽  
Inbred Lines ◽  
Fruit Shape ◽  
Dominant Allele ◽  
Fruit Traits ◽  
New Genes ◽  
Stripe Width ◽  
Narrow Stripe ◽  
Light Green

Genes for watermelon [Citrullus lanatus (Thunb.) Matsumura & Nakai] fruit traits have been identified since the 1930s. We conducted a study of fruit traits including fruit stripe width, stripe color, rind color, fruit shape, and blossom end shape (concave vs. convex). Ten watermelon cultivars (inbred lines) were used as parents. Several new genes or alleles were discovered. A series of alleles at the g locus is proposed to explain the inheritance of fruit rind pattern: G (medium or dark solid green), gW (wide stripe), gM (medium stripe), gN (narrow stripe), and g (solid light green or gray). The dominance series is G > gW > gM > gN > g. Another series of alleles at the ob locus is proposed for the fruit shape: allele ObE for elongate fruit, which is the most dominant; allele ObR (not the same as the o gene for round) for the round fruit; and allele ob for oblong fruit, which is the most recessive. Gene csm is proposed for the clear stripe margin in the cultivar Red-N-Sweet and is recessive to the blurred stripe margin (Csm) in ‘Crimson Sweet’, ‘Allsweet’, and ‘Tendersweet Orange Flesh’.

scholarly journals Development of SNP Markers for White Immature Fruit Skin Color in Cucumber (Cucumis sativus L.) Using QTL-seq and Marker Analyses

Plants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2341
Author(s):  
D. S. Kishor ◽  
Hemasundar Alavilli ◽  
Sang-Choon Lee ◽  
Jeong-Gu Kim ◽  
Kihwan Song
Keyword(s):  
Skin Color ◽  
Genetic Basis ◽  
Recessive Gene ◽  
Genomic Region ◽  
Chromosome 3 ◽  
Missense Mutations ◽  
Cucumis Sativus L ◽  
Immature Fruit ◽  
Fruit Skin ◽  
Light Green

Despite various efforts in identifying the genes governing the white immature fruit skin color in cucumber, the genetic basis of the white immature fruit skin color is not well known. In the present study, genetic analysis showed that a recessive gene confers the white immature fruit skin-color phenotype over the light-green color of a Korean slicer cucumber. High-throughput QTL-seq combined with bulked segregation analysis of two pools with the extreme phenotypes (white and light-green fruit skin color) in an F2 population identified two significant genomic regions harboring QTLs for white fruit skin color within the genomic region between 34.1 and 41.67 Mb on chromosome 3, and the genomic region between 12.2 and 12.7 Mb on chromosome 5. Further, nonsynonymous SNPs were identified with a significance of p < 0.05 within the QTL regions, resulting in eight homozygous variants within the QTL region on chromosome 3. SNP marker analysis uncovered the novel missense mutations in Chr3CG52930 and Chr3CG53640 genes and showed consistent results with the phenotype of light-green and white fruit skin-colored F2 plants. These two genes were located 0.5 Mb apart on chromosome 3, which are considered strong candidate genes. Altogether, this study laid a solid foundation for understanding the genetic basis and marker-assisted breeding of immature fruit skin color in cucumber.

scholarly journals Evidence from chimaeras for the pattern of proliferation of epidermis in the mouse

1977 ◽  
Vol 29 (3) ◽  
pp. 279-284 ◽  
Author(s):  
Margaret C. Green ◽  
Dianne Durham ◽  
Thomas C. Mayer ◽  
Peter C. Hoppe
Keyword(s):  
Cell Proliferation ◽  
Clonal Growth ◽  
Mutant Gene ◽  
Agouti Locus ◽  
Recessive Mutant

SUMMARYThe recessive mutant gene downless (dl) causes abnormal texture of the coat and absence of hair on the tail. The dl locus had previously been shown to act in the epidermis and not in the dermis. To obtain evidence on the pattern of proliferation of epidermis, downless ↔ normal chimaeras were produced by embryo aggregation, and the pattern of normal and mutant hair in the coat was examined. The chimaeras showed a pattern of narrow transverse stripes of normal and abnormal hair. This pattern was similar to that found in mice chimaeric for alleles at the agouti locus known to act in the dermis. This evidence supports the conclusion that the pattern of cell proliferation is similar in dermis and epidermis, and is compatible with the hypothesis that both tissues proliferate by lateral coherent clonal growth from a randomly mixed array of longitudinally arranged cells.

EXTRA-LARGE TRIBOLIUM CONFUSUM: A NEW AUTOSOMAL RECESSIVE MUTANT

1975 ◽  
Vol 17 (4) ◽  
pp. 609-613 ◽  
Author(s):  
H. H. Vardell ◽  
J. H. Brower
Keyword(s):  
Larval Stage ◽  
Generation Time ◽  
Autosomal Recessive ◽  
Recessive Gene ◽  
Tribolium Confusum ◽  
Wild Type ◽  
Mating Competition ◽  
Recessive Mutant ◽  
Males And Females ◽  
Coleoptera Tenebrionidae

A new mutant of Tribolium confusum Jacquelin duVal (Coleoptera: Tenebrionidae), extra-large (designated xl), was isolated in mating competition tests with red-eye (re) and wild-type (+). Crosses showed that it was autosomal recessive gene with subvital effects. The pupal weights averaged 6.1 and 7.3 mg for males and females, respectively, about twice the weights of the ancestral wild-type. The generation time (egg to adult) was approximately 8 to 9 weeks compared with about 4 weeks for the wild-type. This increase resulted from a lengthening of the larval stage since the durations of the egg and pupal stages were within the ranges of the wild-type. Mean longevity of xl males and females was reduced to 8.5 and 6.0 weeks, respectively at 26.7 ± 1 °C and 60% RH.

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