THE BIARMED CHROMOSOMES OF MOUSE CELL LINE LMTK–

1973 ◽  
Vol 15 (4) ◽  
pp. 791-799 ◽  
Author(s):  
Alan R. Rushton
Keyword(s):  
Cell Line ◽  
Reciprocal Translocation ◽  
Normal Mouse ◽  
Centric Fusion ◽  
Mouse Cell ◽  
Centromeric Heterochromatin ◽  
Mouse Cell Line ◽  
Marker Chromosomes

Staining for fluorescent bands and centromeric heterochromatin showed that normal mouse chromosomes could be identified as specific arms in most of the biarmed chromosomes of the mouse cell line LMTK–. Seven marker chromosomes were also characterized. The karyotype was heterogeneous with an average of 9.4 biarmed chromosomes per cell. Five specific biarmed chromosomes were present in at least 90% of the cells examined. The results indicate the presence of both relatively stable and highly variable components in the in vitro karyotype. Evidence is presented which indicates that the biarmed chromosomes have been formed by reciprocal translocation, centric fusion with retention of both centromeres, and centromeric misdivision with isochromosome formation.

In vitro protective effects of Ginkgo biloba against cisplatin toxicity in mouse cell line OCk3

2008 ◽  
Vol 6 (4) ◽  
pp. 251-258 ◽  
Author(s):  
Laura Astolfi ◽  
Edi Simoni ◽  
Andrea Ciorba ◽  
Alessandro Martini
Keyword(s):  
Cell Line ◽  
Ginkgo Biloba ◽  
Mouse Cell ◽  
Protective Effects ◽  
Mouse Cell Line

scholarly journals In vitro cytotoxic effect of Cleistanthus collinus extracts and fractions on mouse cell line

2014 ◽  
Vol 4 (10) ◽  
pp. 44-46 ◽  
Author(s):  
Thamburaj Suman ◽  
Ramaraj Elangomathavan ◽  
Soundherrajan Ilavenil ◽  
Samiraj Ramesh
Keyword(s):  
Cell Line ◽  
Cytotoxic Effect ◽  
Mouse Cell ◽  
Mouse Cell Line

scholarly journals The Central THαβ Immunity Associated Cytokine: IL-10 Has a Strong Anti-Tumor Ability Toward Established Cancer Models In Vivo and Toward Cancer Cells In Vitro

2021 ◽  
Vol 11 ◽  
Author(s):  
Wan-Chung Hu
Keyword(s):  
Immune Response ◽  
Cancer Treatment ◽  
Cell Line ◽  
Immune Cells ◽  
Tumor Volume ◽  
Mouse Cell ◽  
Antibody Treatment ◽  
Mouse Cell Line

Immunotherapy is a promising new approach for cancer treatment. In this study, I propose to use the THαβ-mediated immune response for cancer treatment. The THαβ-mediated immune response is activated by IL-10 and IL-15. Thus, I used IL-10 and-15 as therapeutic agents in the 4T1 cell line, which is a mouse cell line of breast cancer, and the NXS2 cell line, which is a mouse cell line of neuroblastoma. Cells from 4T1 and NXS2 were subcutaneously inoculated in wild type BALB/c female mice and AJ mice, respectively, and administered cytokines or an antibody treatment at various dosages. My results showed that IL-10 and IL-15 administration led to reduction in tumor volume and increase in survival. However, traditional TH1 cytokine IFN-γ administration led to increase in tumor volume and decline in survival. Antibody treatment in conjunction with IL-10 was not significantly better than IL-10, due to the expression of GD2 on immune cells. Moreover, an anti-GD2 antibody inhibited the immune cells themselves. Additionally, I found that IL-10 was directly toxic to tumor cells in vitro. Thus, I conclude that the THαβ immunological pathway is a good treatment strategy for cancer.

scholarly journals Purification and characterization of adenosine deaminase from a genetically enriched mouse cell line.

1985 ◽  
Vol 260 (24) ◽  
pp. 13261-13267 ◽  
Author(s):  
D E Ingolia ◽  
C Y Yeung ◽  
I F Orengo ◽  
M L Harrison ◽  
E G Frayne ◽  
...  
Keyword(s):  
Cell Line ◽  
Adenosine Deaminase ◽  
Mouse Cell ◽  
Purification And Characterization ◽  
Mouse Cell Line
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