DIRECT AND MATERNAL GENETIC RESPONSES RESULTING FROM SELECTION FOR 12-DAY LITTER WEIGHT IN MICE

1973 ◽  
Vol 15 (3) ◽  
pp. 483-490 ◽  
Author(s):  
E. J. Elsen
Keyword(s):  
Body Weight ◽  
Genetic Variance ◽  
Selection Response ◽  
Genetic Effects ◽  
Direct Effects ◽  
Litter Weight ◽  
Environmental Component ◽  
Selection For ◽  
Genetic Responses ◽  
And Control

Response to selection for 12-day litter weight in mice was evaluated in terms of average direct and average maternal genetic responses. Comparisons were made among selected and control parental lines, reciprocal F1 crosses, F2's and backcrosses. Selection response in 12-day body weight was primarily due to average direct genetic effects. Correlated responses in body weight at 21, 31, 42 and 70 days also were due to average direct effects. Average maternal genetic effects contributed little to direct or correlated weight responses. Heterosis for direct genetic effects was not significant for 12- and 21-day body weights but was important for postweaning weights. In contrast, heterosis for maternal genetic effects was important at 12 and 21 days but declined after weaning. These results suggest that the maternal genetic influence on neonatal mammalian growth may play a key role in fitness of the offspring. Thus, natural selection would tend to reduce additive maternal genetic variance, leaving mainly non-additive maternal genetic variance. This, coupled with the large maternal environmental component influencing neonatal growth, suggests that selection for additive direct effects influencing preweaning growth in livestock would be most efficiently carried out by standardizing or eliminating the postnatal maternal environment.

GENETIC ANALYSIS OF NURSE DAMS SELECTED FOR SIX-WEEK BODY WEIGHT OR POSTWEANING GAIN IN MICE

1976 ◽  
Vol 18 (4) ◽  
pp. 611-623 ◽  
Author(s):  
J. Nagai ◽  
H. Bakker ◽  
E. J. Eisen
Keyword(s):  
Body Weight ◽  
Feed Intake ◽  
Selection Response ◽  
Genetic Effects ◽  
Control Group ◽  
Correlated Response ◽  
Population Differences ◽  
Correlated Responses ◽  
Maternal Performance ◽  
And Control

A modified crossfostering technique was developed to compare the performance of nurse dams in selected and control populations of mice. The H6 and M16 populations were selected for increased 6-week body weight and 3- to 6-week postweaning gain, respectively, while the C2 and ICR populations were the respective controls. Crossfostering was performed using H6, M16 and their reciprocal F1 crosses as nurse dams in the selected crossfostering group and C2, ICR and their reciprocals in the control group. Measurements recorded for nurse dams included mean body weight of 8 young within a nursed litter at birth (MWB) and 12 days of age (MW12). The latter was used as a measure of postnatal maternal performance. Other traits recorded for nurse dams were number born (NB), body weight at parturition (DWP) and 12 days postpartum (DW12), and weight gain (DWG), feed intake (FED) and efficiency (EFF = DWG/FED) for the first 12 days of lactation. The correlated response in MW12 was negative (P <.01) for M16 and essentially zero for H6. Both lines exhibited positive (P <.01) correlated responses in DWP and DW12 and no change in EFF. Only the H6 line increased significantly in DWG and FED as a result of selection. NB increased in M16 and H6, but was significant for the latter population only. Population differences in selection response [(M16-ICR)-(H6-C2)] were significant for FED only, primarily due to average direct genetic effects. Direct comparisons of M16 and H6 indicated that M16 was larger in DWP and DW12 but smaller in DWG and EFF. Average direct genetic effects favored M16 for NB, DWP, and DW12, whereas average maternal genetic effects favored H6 for NB, DWP, DW12 and FED. Percent direct heterosis in F1 crosses of the selected populations was significant for MW12 (13.7%), FED (10.8%) and NB (11.4%). Direct heterosis in F1 crosses of the controls was significant for MW12 (9.4%), NB(6.6%), DWP (3.5%), DW12 (3.3%) and FED (4.4%). The effects of MW12, DWG and metabolic body size (MBS) accounted for 47% of the variation in FED, pooled within populations. Of these variables, MW12 accounted for the highest proportion (32%) of variation in total feed intake.

ESTIMASI NILAI HERITABILITAS BOBOT IKAN MAS VARIETAS PUNTEN DALAM PROGRAM SELEKSI INDIVIDU

2016 ◽  
Vol 11 (3) ◽  
pp. 217
Author(s):  
Estu Nugroho ◽  
Budi Setyono ◽  
Mochammad Su’eb ◽  
Tri Heru Prihadi
Keyword(s):  
Body Weight ◽  
Selection Response ◽  
Base Population ◽  
Breeding Programs ◽  
Male And Female ◽  
Body Weight Trait ◽  
Population Selection ◽  
Selection For ◽  
Weight Trait ◽  
Selection Of

Program pemuliaan ikan mas varietas Punten dilakukan dengan seleksi individu terhadap karakter bobot ikan. Pembentukan populasi dasar untuk kegiatan seleksi dilakukan dengan memijahkan secara massal induk ikan mas yang terdiri atas 20 induk betina dan 21 induk jantan yang dikoleksi dari daerah Punten, Kepanjen (delapan betina dan enam jantan), Kediri (tujuh betina dan 12 jantan), Sragen (27 betina dan 10 jantan), dan Blitar (15 betina dan 11 jantan). Larva umur 10 hari dipelihara selama empat bulan. Selanjutnya dilakukan penjarangan sebesar 50% dan benih dipelihara selama 14 bulan untuk dilakukan seleksi dengan panduan hasil sampling 250 ekor individu setiap populasi. Seleksi terhadap calon induk dilakukan saat umur 18 bulan pada populasi jantan dan betina secara terpisah dengan memilih berdasarkan 10% bobot ikan yang terbaik. Calon induk yang terseleksi kemudian dipelihara hingga matang gonad, kemudian dipilih sebanyak 150 pasang dan dipijahkan secara massal. Didapatkan respons positif dari hasil seleksi berdasarkan bobot ikan, yaitu 49,89 g atau 3,66% (populasi ikan jantan) dan 168,47 g atau 11,43% (populasi ikan betina). Nilai heritabilitas untuk bobot ikan adalah 0,238 (jantan) dan 0,505 (betina).Punten carp breeding programs were carried out by individual selection for body weight trait. The base population for selection activities were conducted by mass breeding of parent consisted of 20 female and 21 male collected from area Punten, eight female and six male (Kepanjen), seven female and 12 male (Kediri), 27 female and 10 male (Sragen), 15 female and 11 male (Blitar). Larvae 10 days old reared for four moths. Then after spacing out 50% of total harvest, the offspring reared for 14 months for selection activity based on the sampling of 250 individual each population. Selection of broodstock candidates performed since 18 months age on male and female populations separately by selecting based on 10% of fish with best body weight. Candidates selected broodstocks were then maintained until mature. In oder to produce the next generation 150 pairs were sets and held for mass spawning. The results revealed that selection response were positive, 49.89 g (3.66%) for male and 168.47 (11.43%) for female. Heritability for body weight is 0.238 (male) and 0.505 (female).

Composite trait selection to improve reproduction and ewe productivity: a review

2009 ◽  
Vol 49 (1) ◽  
pp. 9 ◽  
Author(s):  
G. D. Snowder ◽  
N. M. Fogarty
Keyword(s):  
Individual Component ◽  
Genetic Relationships ◽  
Reproductive Efficiency ◽  
Component Trait ◽  
Litter Weight ◽  
Growth Selection ◽  
Component Traits ◽  
Selection For ◽  
Genetic Responses ◽  
Lamb Growth

Reproduction and ewe productivity are complex composite traits that are influenced by several component traits. Genetic improvement by selection for an individual component trait may not always be advantageous because adverse or neutral genetic relationships can exist among the component traits. Selection for an overall composite trait of ewe productivity, defined as litter weight weaned per ewe joined, can result in a balanced biological composite trait with favourable responses in component traits including fertility, number of lambs born, lamb survival, lactation and lamb growth. Selection for litter weight weaned may also overcome adverse genetic relationships among reproductive component traits. This review examines the genetic responses of selecting directly for litter weight weaned, compared with selection responses for one or more of its component traits. It is concluded that selection to improve reproductive efficiency and ewe productivity, under most production and environmental systems, would benefit from selection for a composite trait such as litter weight weaned, rather than for a single component trait.

scholarly journals LONG-TERM SELECTION RESPONSE FOR 12-DAY LITTER WEIGHT IN MICE

Genetics ◽  
1972 ◽  
Vol 72 (1) ◽  
pp. 129-142
Author(s):  
E J Eisen
Keyword(s):  
Body Weight ◽  
Genetic Correlation ◽  
Half Life ◽  
Selection Process ◽  
Selection Response ◽  
Exponential Model ◽  
Correlated Response ◽  
Term Selection ◽  
Litter Weight

ABSTRACT Long-term selection for increased 12-day litter weight in two replicate lines (W2, W3) of mice resulted in an apparent selection limit at about 17 generations. Quadratic polynomial and exponential models were fitted to the data in order to estimate the plateaued response and half-life of the selection process. Using the polynomial results, the half-life estimates were 4.5 and 8.6 generations for W2 and W3, respectively. The plateaued responses were 5.1 and 5.8 g which, when expressed in phenotypic standard deviation units, became 1.1 and 1.3. The exponential model provides similar estimates. A negative association between 12-day litter weight and fitness was not considered to be an adequate explanation for the plateau since there was no decrease in fertility of the selected lines. Evidence that exhaustion of genetic variability was not the cause of the plateau came from the immediate response to reverse selection. It was proposed that the plateau may be due to a negative genetic correlation between direct and maternal genetic effects, which would be expected to occur after many generations of selection. There were positive correlated responses in both replicates for adult body weight, which was in agreement with the positive genetic correlation between preweaning and postweaning body weight. The expected positive correlated response for number born was realized in only one of the replicates.

scholarly journals Accumulation of mutations affecting body weight in inbred mouse lines

1995 ◽  
Vol 65 (2) ◽  
pp. 145-149 ◽  
Author(s):  
Armando Caballero ◽  
Peter D. Keightley ◽  
William G. Hill
Keyword(s):  
Body Weight ◽  
Maximum Likelihood ◽  
Genetic Variance ◽  
Inbred Mouse ◽  
Additive Genetic Variance ◽  
Selection Response ◽  
Spontaneous Mutations ◽  
Line Selection ◽  
Divergence Estimates ◽  
Mouse Lines

SummaryThe variation from spontaneous mutations for 6-week body weight in the mouse was estimated by selection from a cross of two inbred sublines, C57BL/6 and C57BL/10, separated about 50 years previously from the same inbred line. Selection was practised high and low for 12 generations from theF2, followed by one generation of relaxation. The lines diverged by approximately 1·7 g or 0·7 sd. The additive genetic variance was estimated in theF2by restricted maximum likelihood and from the selection response, and from this variance the mutational heritabilityhM2was estimated using the number of generations since divergence. Estimates ofhM2range from 0·08 to 0·10% depending on the method of analysis. These estimates are similar to those found for other species, but lower than other estimates for the mouse. It is concluded that substantial natural and, perhaps, artificial selection operated during the maintenance of the sublines.

Genetic variation in a line of mice selected to its limit for high body weight

1974 ◽  
Vol 19 (3) ◽  
pp. 273-289 ◽  
Author(s):  
W. K. Al-Murrani ◽  
R. C. Roberts
Keyword(s):  
Body Weight ◽  
Genetic Variance ◽  
Genetic Model ◽  
Random Mating ◽  
Inbred Lines ◽  
High Body Weight ◽  
High Body ◽  
Lower Body Weight ◽  
Recessive Genes ◽  
Selection For

SUMMARYA line of mice, at its limit to selection for high body weight did not decline in performance over 11 generations of random mating, neither did it respond when selection was renewed. The experiment tested a method of improving body weight by a scheme which had earlier increased litter size under similar circumstances. The scheme was to derive partially inbred lines from the plateaued line, to select during inbreeding and, finally, to cross the best inbreds. Body weight was not increased, but the study allowed further examination of the residual genetic variance in the line.During inbreeding, the inbred lines became clearly differentiated in body weight, proving that loci controlling body weight had not become fixed. There was also a significant response to selection for a lower body weight during inbreeding. The pattern of results suggested the segregation of recessive genes, detrimental to high body weight but which selection had become inefficient at removing. A genetic model compatible with the results accommodated several such recessives, perhaps as many as 10, each with an effect of about two-thirds of a standard deviation (or some equivalent combination of gene number and effect), and at frequencies of around 0·2. Nevertheless, the total improvement in body weight to be gained by their elimination was only half a gram, or less than 2 %. Thus, substantial genetic effects can occur at individual loci despite trivially low heritabilities and negligible potential gains.

Relationship between litter size and perinatal and pre-weaning survival in pigs

2002 ◽  
Vol 74 (2) ◽  
pp. 217-222 ◽  
Author(s):  
M. S. Lund ◽  
M. Puonti ◽  
L. Rydhmer ◽  
J. Jensen
Keyword(s):  
Litter Size ◽  
Negative Correlation ◽  
Genetic Effects ◽  
Direct Effects ◽  
Selection For ◽  
Heritability Estimates ◽  
The Relationship ◽  
Piglet Survival

AbstractThe objective of this study was to analyse the relationship between direct and maternal genetic effects on litter size and piglet survival. The analyses were performed on records from 26 564 Landrace litters and 15 103 Yorkshire litters from first parity dams in Finnish herds. The trivariate model fitted total number of piglets born, proportion alive at birth and proportion survived from birth until 3 weeks as traits of the litter. The model included direct genetic and maternal genetic effects for all traits. In Landrace pigs, maternal heritabilities were estimated to be 0·11 for total number born, 0·06 for proportion alive at birth, and 0·08 for proportion survived from birth until 3 weeks. The corresponding estimates for the Yorkshire breed were 0·14, 0·06 and 0·01. All heritability estimates of direct effects were below 0·05. In the Landrace breed, there was a negative correlation of -0·39 between maternal genetic effects on total number born and maternal genetic effects on proportion survived from birth until 3 weeks and a negative correlation of -0·41 between direct and maternal genetic effects on proportion survived from birth until 3 weeks. These correlations were not significant in the Yorkshire breed. The results show that selection for number born in total alone will lead to a deterioration in the maternal ability of sows. Selection for pre-weaning survival could be achieved by selecting on direct and maternal components jointly.

scholarly journals The limits to artificial selection for body weight in the mouse: IV. Sources of new genetic variance—irradiation and outcrossing

1967 ◽  
Vol 9 (1) ◽  
pp. 87-98 ◽  
Author(s):  
R. C. Roberts
Keyword(s):  
Body Weight ◽  
Artificial Selection ◽  
Genetic Variance ◽  
Additive Genetic Variance ◽  
Negative Results ◽  
Selection For ◽  
The Cross

1. Two methods are examined of introducing new genetic variance into a line of mice selected for high 6-week weight which, at its limit, displayed no additive genetic variance.2. The first method—irradiation—gave largely negative results. Any further gain under selection that was achieved could not be clearly distinguished from a possible environmental trend.3. The second method—outcrossing to an unselected strain and then selecting from the cross—resulted in a clear gain over the original limit, but nine generations were required even to recover the original limit.4. Various methods of transcending selection limits are evaluated in terms of their application to livestock improvement.

scholarly journals INTERACTION BETWEEN NATURAL SELECTION FOR HETEROZYGOTES AND DIRECTIONAL SELECTION

Genetics ◽  
1974 ◽  
Vol 76 (1) ◽  
pp. 163-168
Author(s):  
Margrith Wehrli Verghese
Keyword(s):  
Natural Selection ◽  
First Generation ◽  
Genetic Variance ◽  
Selection Response ◽  
Directional Selection ◽  
Simple Function ◽  
Small Populations ◽  
Gene Frequencies ◽  
Selection For

ABSTRACT When directional selection for an additively inherited trait is opposed by natural selection favoring heterozygous genotypes a selection plateau may be reached where genetic variance is present. The amount of response when this plateau is reached is a simple function of the selection response in the first generation and the intensity of natural selection. When selection is practiced in small populations, the sizes of the initial equilibrium gene frequencies are at least as important as the intensity of natural selection in determining the probability of fixing desirable alleles.

scholarly journals Selection for Increased Budbreak in Apple

2003 ◽  
Vol 128 (3) ◽  
pp. 363-373 ◽  
Author(s):  
Iwan F. Labuschagné ◽  
J.H. Louw ◽  
Karin Schmidt ◽  
Annalene Sadie
Keyword(s):  
Genetic Variance ◽  
Screening Method ◽  
Selection Response ◽  
Significant Response ◽  
Correlated Response ◽  
Realized Heritability ◽  
Early Screening ◽  
Adult Trees ◽  
Selection For ◽  
Combined Selection

Significant response to selection for budbreak number (NB) based on data recorded on 1-year-old shoots of young apple (Malus sylvestris (L.) Mill var. domestica (Borkh.) Mansf.) seedlings (Expt. I) and branches from adult seedling trees (Expt. II) has been demonstrated in clonally propagated seedling trees. Between family variation for NB was low and masked by year × family interaction effects. Realized heritability for NB was estimated as 40% to 60%. Correlated response in uniformity and position of budbreak, and in the number and length of side shoots, was found. Association between the time of budbreak (TB) and NB, according to midparent and cross groupings, and according to the parental means, indicate a positive genetic correlation between these traits. Where data on adult trees were used as a measure of selection response and tested on young clonal trees, significant response and genetic variation was shown, confirming the presence of utilizable genetic variance and that this procedure may be successfully applied as an early screening method for increased budbreak in adult trees. Combined selection utilizing genetic variance between crosses as well as within crosses is proposed as the best procedure to increase the frequency of seedlings with increased budbreak and to improve adaptation to low winter chilling conditions.

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