STUDIES OF NATURAL POPULATIONS OF MUS. V. A SURVEY OF NINE LOCI FOR POLYMORPHISMS

1969 ◽  
Vol 11 (3) ◽  
pp. 497-513 ◽  
Author(s):  
M. L. Petras ◽  
J. D. Reimer ◽  
F. G. Biddle ◽  
J. E. Martin ◽  
R. S. Linton
Keyword(s):  
Geographic Distribution ◽  
Mus Musculus ◽  
Additional Data ◽  
Natural Populations ◽  
House Mice ◽  
Polymorphic Loci

An examination of house mice (Mus musculus) from a number of sites in southwestern Ontario revealed six loci (Hbb, Es-2, Es-3, Es-5, Ldr-1 and A) to be polymorphic and three (Es-1, Pro-1 and Trf-1) to be monomorphic. A comparison of the Ontario samples with samples from southeastern Michigan suggests that the polymorphisms detected are common to Mus populations in both regions and are relatively stable. Data reported by other investigators suggest that some of these polymorphisms have a broad geographic distribution. Also discussed are findings of loci described elsewhere. Two of these T and Ea-1, are polymorphic in some of the populations under consideration. General conclusions include: (1) that polymorphic loci are probably as frequent in mouse populations as in Drosophila and man; (2) that the polymorphisms observed are relatively stable and widespread; (3) that some of the alleles responsible for the polymorphisms observed are not neutral; and (4) that additional data are necessary to elucidate the mechanisms responsible for the polymorphisms observed.

What can the geographic distribution of mtDNA haplotypes tell us about the invasion of New Zealand by house mice Mus musculus?

2016 ◽  
Vol 18 (6) ◽  
pp. 1551-1565 ◽  
Author(s):  
Carolyn King ◽  
Alana Alexander ◽  
Tanya Chubb ◽  
Ray Cursons ◽  
Jamie MacKay ◽  
...  
Keyword(s):  
New Zealand ◽  
Geographic Distribution ◽  
Mus Musculus ◽  
House Mice ◽  
Mtdna Haplotypes

scholarly journals The maintenance of polymorphisms at two loci in house mouse (Mus musculus) populations

1983 ◽  
Vol 25 (2) ◽  
pp. 190-201 ◽  
Author(s):  
Michael L. Petras ◽  
John C. Topping
Keyword(s):  
Mus Musculus ◽  
Migration Rate ◽  
Polymorphic Locus ◽  
Natural Populations ◽  
House Mice ◽  
Migration Model ◽  
Rapid Extinction ◽  
Hemoglobin Molecule ◽  
Β Chain ◽  
High Migration

To determine the roles of mutation, migration, and selection in maintaining genetic variability in populations of house mice (Mus musculus), stochastic models based on characteristics of mouse populations inhabiting corn cribs in southwestern Ontario and the t allele were developed. Two sets of models were examined. One involved selection against t/t mice and a migration rate of 0.05 to 0.10 (low migration model) whereas the other involved selection against both t/t and +/t genotypes and a migration rate of 0.33 (high migration model). Both models could account for the t allele frequencies observed in natural populations. Similarly both models explain the frequencies observed at a second polymorphic locus, the Hbb locus which controls the β chain of the hemoglobin molecule, provided strong selection favoring the Hbb heterozygotes is incorporated. Without such selection pressure rapid extinction of one of the alleles at this locus occurred. A stabilizing force such as selection is considered necessary for the hemoglobin polymorphism observed in the populations under consideration. Evidence supporting the high migration model as the more realistic is also presented.

The contribution of raptorial birds to patterning in small mammal assemblages

Paleobiology ◽  
1988 ◽  
Vol 14 (1) ◽  
pp. 81-90 ◽  
Author(s):  
Rob Hoffman
Keyword(s):  
Small Mammal ◽  
Mus Musculus ◽  
House Mice ◽  
Potential Contribution ◽  
Quantitative Analyses ◽  
Interspecies Variability ◽  
Fossil Assemblages ◽  
Mammal Assemblages

Seven taxa of raptorial birds were experimentally fed a controlled sample of 50 house mice (Mus musculus). Bones recovered from the pellets were examined for interspecies variability in preservation to assess the potential contribution of specific raptors to patterning in fossil assemblages. Quantitative analyses demonstrate that patterns in bone fragmentation may assist in the identification of particular raptor species as depositional agents in small mammal assemblages.

scholarly journals Insights into mammalian biology from the wild house mouse Mus musculus

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Megan Phifer-Rixey ◽  
Michael W Nachman
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Genetic Model ◽  
Inbred Strains ◽  
Mendelian Inheritance ◽  
Model Organisms ◽  
House Mice ◽  
Small Subset ◽  
Wild Mice ◽  
Wide Range

The house mouse, Mus musculus, was established in the early 1900s as one of the first genetic model organisms owing to its short generation time, comparatively large litters, ease of husbandry, and visible phenotypic variants. For these reasons and because they are mammals, house mice are well suited to serve as models for human phenotypes and disease. House mice in the wild consist of at least three distinct subspecies and harbor extensive genetic and phenotypic variation both within and between these subspecies. Wild mice have been used to study a wide range of biological processes, including immunity, cancer, male sterility, adaptive evolution, and non-Mendelian inheritance. Despite the extensive variation that exists among wild mice, classical laboratory strains are derived from a limited set of founders and thus contain only a small subset of this variation. Continued efforts to study wild house mice and to create new inbred strains from wild populations have the potential to strengthen house mice as a model system.

Phylogeography of Chinese house mice (Mus musculus musculus/castaneus): distribution, routes of colonization and geographic regions of hybridization

2014 ◽  
Vol 23 (17) ◽  
pp. 4387-4405 ◽  
Author(s):  
Meidong Jing ◽  
Hon-Tsen Yu ◽  
Xiaoxin Bi ◽  
Yung-Chih Lai ◽  
Wei Jiang ◽  
...  
Keyword(s):  
Mus Musculus ◽  
House Mice ◽  
Mus Musculus Musculus ◽  
Geographic Regions
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