Effects of Metal Poisoning on Five Liver Enzymes in the Killifish (Fundulus heteroclitus)

1970 ◽  
Vol 27 (2) ◽  
pp. 383-390 ◽  
Author(s):  
Eugene Jackim ◽  
Janice M. Hamlin ◽  
Stephen Sonis
Keyword(s):  
Alkaline Phosphatase ◽  
Enzyme Activity ◽  
Xanthine Oxidase ◽  
Liver Enzyme ◽  
Fundulus Heteroclitus ◽  
Liver Enzymes ◽  
Enzyme Preparations ◽  
Liver Enzyme Activity ◽  
Acid And Alkaline Phosphatase ◽  
Metal Poisoning

Activities of five liver enzymes (acid and alkaline phosphatase, catalase, xanthine oxidase, and ribonuclease) from Fundulus heteroclitus surviving exposure to 96-hr TLm concentrations of salts of six metals (lead, copper, mercury, beryllium, cadmium, and silver) differed markedly from those of unexposed fish. Changes in enzyme activity produced by the exposures were not necessarily the same in magnitude or direction as those observed when the salts were introduced directly into the enzyme preparations. It is proposed that changes in liver enzyme activity may be useful as a kind of biochemical autopsy tool for diagnosing sublethal metal poisoning in fish.

scholarly journals Study the effect of a new nikel (II) Complex and anticancer drug (cp) on Liver enzyme activity (GPT,GOT) and Creatinine level in Kidney of femal mice

2014 ◽  
Vol 11 (3) ◽  
pp. 1100-1106
Author(s):  
Baghdad Science Journal
Keyword(s):  
Enzyme Activity ◽  
Creatinine Level ◽  
Liver Enzyme ◽  
Liver Enzymes ◽  
Cancer Drug ◽  
Inhibition Rate ◽  
Liver Enzyme Activity ◽  
Maximum Inhibition ◽  
Anti Cancer ◽  
Maximum Activation

This study involved the effect of anew nickel (II) complexs with formla [NiL2(H2O)2].2.5ETOH where L=Bis[5-(p-nitrophenyL)-4-phenyL-1,2,4-traizole-3-dithocarbamato hydrazide] diaqua. nickel(II). Ethanol(2.5).and anti-cancer drug cyclophosphamide on specific actifity of two Liver enzymes (GOT,GPT) in the (Liver,kidney) tissues and on the creatinine Level in the kidney byUtilizing an invivosystem in femalmice.The result showed that inhibition in the activity of GPT and GOT enzymes in theLiver and in both nickel (II) complex and cyclophosphamide drug (CP) . mice weretreated with three doses (90,180,320) µg/mouse for three days for each group.The Liver show's the highest rate of GPT inhibition was about 97.43% at180µg/mouse regarding the kidney the inhibition rate was about 98.63% at 180µg/mouse .The maximum inhibition of GOT enzame in the Liver was about 77. 48% ataconcentration 180µg/mouse and the inhbition rate of GOT enzyme in the kidney was about 97.87% at aconcentration 320µg/mouse.The result showed the effect of nickel (II) complex on the creatinine Level in the kidney ,The maximum activation was about 99.45% at 320µg/mouse.

scholarly journals The effect of paracetamol on human Chang liver cells infected by different dengue serotypes based on liver enzyme activity

2012 ◽  
Vol 16 ◽  
pp. e107
Author(s):  
H. Roslee ◽  
C. Hui Yee ◽  
S. Fakurazi ◽  
F. Azizi Jalilian ◽  
F. Othman ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Liver Enzyme ◽  
Liver Cells ◽  
Liver Enzyme Activity ◽  
Chang Liver

Regulation of Corticosterone Levels and Liver Enzyme Activity in Aging Rats

1975 ◽  
pp. 209-228 ◽  
Author(s):  
Gary W. Britton ◽  
Samuel Rotenberg ◽  
Colette Freeman ◽  
Venera J. Britton ◽  
Karen Karoly ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Liver Enzyme ◽  
Aging Rats ◽  
Liver Enzyme Activity

FREEZING DAMAGE TO BOVINE CREAM INDICATED BY RELEASE OF ENZYMES

1959 ◽  
Vol 37 (7) ◽  
pp. 821-827 ◽  
Author(s):  
L. J. N. Cole ◽  
D. Kluepfel ◽  
C. V. Lusena
Keyword(s):  
Alkaline Phosphatase ◽  
Enzyme Activity ◽  
Xanthine Oxidase ◽  
Aqueous Phase ◽  
The Other ◽  
Rapid Freezing ◽  
Freezing Damage ◽  
Membrane Material ◽  
Fat Globules ◽  
Main Effect

When washed cream was frozen slowly and thawed, some breaking of the emulsion occurred and on centrifugation a pellet, mostly membrane material, was obtained. Xanthine oxidase and alkaline phosphatase were present in this pellet, but little enzyme activity was found in the aqueous phase. The main effect of slow freezing was to force the fat globules together so that alteration and redistribution of the membranes could occur, and, on thawing, fat could coalesce. Rapid freezing on the other hand distributed fat globules more evenly so that less coalescence could occur on thawing.

scholarly journals Phosphorylation of purified bovine heart and rat liver 6-phosphofructo-2-kinase by protein kinase C and comparison of the fructose-2,6-bisphosphatase activity of the two enzymes

1986 ◽  
Vol 240 (1) ◽  
pp. 57-61 ◽  
Author(s):  
M H Rider ◽  
L Hue
Keyword(s):  
Alkaline Phosphatase ◽  
Enzyme Activity ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Exchange Reaction ◽  
Liver Enzyme ◽  
Rat Liver ◽  
Phosphorylation State ◽  
Bovine Heart ◽  
Kinase C

Purified bovine heart 6-phosphofructo-2-kinase can be phosphorylated in the presence of protein kinase C and dephosphorylated by alkaline phosphatase; changes in phosphorylation state have no effect on enzyme activity. By contrast, the rat liver enzyme is a poor substrate for protein kinase C. Unlike the liver enzyme, which is bifunctional and is phosphorylated by fructose 2,6-[2-32P]bisphosphate, the heart enzyme contains 10 times less fructose 2,6-bisphosphatase activity and is phosphorylated at a slower rate and to a lesser extent than the liver enzyme. Both rat liver and bovine heart enzymes catalyse a similar exchange reaction between [U-14C]ADP and ATP.

FREEZING DAMAGE TO BOVINE CREAM INDICATED BY RELEASE OF ENZYMES

1959 ◽  
Vol 37 (1) ◽  
pp. 821-827 ◽  
Author(s):  
L. J. N. Cole ◽  
D. Kluepfel ◽  
C. V. Lusena
Keyword(s):  
Alkaline Phosphatase ◽  
Enzyme Activity ◽  
Xanthine Oxidase ◽  
Aqueous Phase ◽  
The Other ◽  
Rapid Freezing ◽  
Freezing Damage ◽  
Membrane Material ◽  
Fat Globules ◽  
Main Effect

When washed cream was frozen slowly and thawed, some breaking of the emulsion occurred and on centrifugation a pellet, mostly membrane material, was obtained. Xanthine oxidase and alkaline phosphatase were present in this pellet, but little enzyme activity was found in the aqueous phase. The main effect of slow freezing was to force the fat globules together so that alteration and redistribution of the membranes could occur, and, on thawing, fat could coalesce. Rapid freezing on the other hand distributed fat globules more evenly so that less coalescence could occur on thawing.

scholarly journals Prospective Study of Liver Function following Repeat Halothane and Enflurane

1981 ◽  
Vol 74 (4) ◽  
pp. 286-291 ◽  
Author(s):  
J W Dundee ◽  
PDA McIlroy ◽  
J P H Fee ◽  
G W Black
Keyword(s):  
Enzyme Activity ◽  
Liver Function ◽  
Prospective Study ◽  
Liver Enzyme ◽  
Similar Group ◽  
Volatile Agent ◽  
Short Intervals ◽  
Liver Enzyme Activity ◽  
A Prospective Study

In a prospective study of liver function following repeat anaesthesia, patients who received repeat halothane had a higher frequency of abnormal liver enzyme results than a similar group who received repeat enflurane. Obesity and short intervals between administrations increased the likelihood of abnormal liver enzyme activity in the halothane group. Enflurane would seem to be the volatile agent of choice for repeat anaesthesia in such circumstances.

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